Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

Rubio-Guerra, Alberto Francisco; Cabrera-Miranda, Luis J.; Vargas‐Robles, Hilda; Maceda-Serrano, Alberto; Lozano-Nuevo, José Juan; Escalante-Acosta, Bruno Alfonso

doi:10.1159/000348651

Cited by 27 publications

(14 citation statements)

References 24 publications

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“…Prior studies have shown resistin to be linked to both endothelial and cardiomyocyte dysfunction, as well as alterations in cholesterol metabolism. Accordingly, the association of resistin with subclinical atherosclerosis has been illustrated by its relationship to elevated coronary artery calcium levels 11 and increased carotid intima-media thickness 37 . Our study extends beyond subclinical atherosclerosis and focuses in on CVD events.…”

Section: Discussionmentioning

confidence: 99%

The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

Muse¹,

Feldman²,

Blaha³

et al. 2015

Atherosclerosis

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Objective To describe the relationship between circulating resistin levels and cardiovascular diseases (CVD) and all-cause death in a multi-ethnic cohort. Methods and Results We studied 1,913 participants from the Multi-Ethnic Study of Atherosclerosis with measurements of plasma resistin levels. Absolute proportions experiencing new-onset atrial fibrillation (AF), atherosclerotic CVD (myocardial infarction, angina, resuscitated cardiac arrest, stroke), heart failure (HF), and all-cause death were calculated for each quartile of resistin. We used adjusted Cox proportional regression modeling resistin as a continuous variable per standard deviation of log-transformed resistin and secondarily as a categorical variable using resistin quartiles. Results were stratified by sex and race/ethnicity. The mean age of the population was 64.5 ± 10 years with half being female and a median resistin concentration of 15.1 ng/mL (11.9–19.1). Mean follow-up time was 7.2 ± 1.8 years. There was a graded increase in the occurrence of all outcomes across increasing quartiles of resistin. Modeled as a continuous variable, after adjustment for anthropomorphic measures, traditional risk factors, markers of inflammation, and other adipokines, significant associations were noted for HF (HR 1.4, CI 1.0–2.0), hard and all CVD (HR 1.3, 1.1–1.7 and 1.3, 1.1–1.6, respectively), and CHD (HR 1.31, 1.0–1.6), but not for AF or death. Significant interaction terms were noted between resistin and race, with Hispanic race/ethnicity showing the strongest relationship between resistin and outcomes. Conclusions In an ethnically diverse population without known CVD at baseline, there was a strong, independent association between higher resistin levels and incident CVD, CHD and HF.

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Section: Discussionmentioning

confidence: 99%

The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

Muse¹,

Feldman²,

Blaha³

et al. 2015

Atherosclerosis

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“…Our group has shown that the levels of VCAM-1 correlate with the severity of albuminuria in diabetic hypertensive patients [15] . In addition, Seron et al [16] reported that VCAM-1 expression is increased in kidney biopsies from patients with DN, they also found a correlation between levels of VCAM-1 and numbers of infiltrating immune cells [18] .…”

Section: Adhesion Moleculesmentioning

confidence: 97%

Diabetic nephropathy and inflammation

Durán-Salgado¹

2014

WJD

334

234

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Diabetic nephropathy (DN) is the leading cause of end-stage renal failure worldwide. Besides, diabetic nephropathy is associated with cardiovascular disease, and increases mortality of diabetic patients. Several factors are involved in the pathophysiology of DN, including metabolic and hemodynamic alterations, oxidative stress, and activation of the renin-angiotensin system. In recent years, new pathways involved in the development and progression of diabetic kidney disease have been elucidated; accumulated data have emphasized the critical role of inflammation in the pathogenesis of diabetic nephropathy. Expression of cell adhesion molecules, growth factors, chemokines and pro-inflammatory cytokines are increased in the renal tissues of diabetic patients, and serum and urinary levels of cytokines and cell adhesion molecules, correlated with albuminuria. In this paper we review the role of inflammation in the development of diabetic nephropathy, discussing some of the major inflammatory cytokines involved in the pathogenesis of diabetic nephropathy, including the role of adipokines, and take part in other mediators of inflammation, as adhesion molecules.

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“…It is also important to note that our patients were naive to thiazolindinedione, statin and angiotensin-converting enzymes/angiotensin II receptor blockers, because these drugs have been shown to modify circulating levels of adipocytokines (1).…”

Section: Discussionmentioning

confidence: 99%

“…Due to the role of hypoadiponectinemia and hyperresistinemia in the development of insulin resistance and in the pathways that lead to atherosclerosis, both adipocytokines are potential treatment targets. In fact, increasing adiponectin and reducing resistin levels contribute to reducing the risk for cardiovascular disease (1,12).…”

Section: Discussionmentioning

confidence: 99%

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Effect of atorvastatin on circulating adipocytokine levels in diabetic patients

Guerra¹,

Robles²

2015

Curr Res Cardiol

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BACKGROUND: Adipocytokines are adipocyte-secreted hormones that have a role in the effects of insulin, metabolism, endothelial function, vascular damage and cardiac disease. Statins have been shown to have cardioprotective effects and to modulate adipose tissue function; however, the effect of each statin on the circulating concentrations of adipocytokines varies. OBJECTIVES: To evaluate the effect of atorvastatin on adipocytokine levels in normotensive patients with type 2 diabetes. METHODS: Twenty patients with type 2 diabetes and naive to statins and inhibitors of the renin-angiotensin systems received 10 mg atorvastatin once per day over a three-month period. Adiponectin and resistin levels were measured using ELISA at the beginning and conclusion of the study. Patients were evaluated monthly for blood pressure, fasting serum glucose levels, lipid profile and adverse events. Statistical analysis was performed using the Mann-Whitney U test RESUlTS: All patients demonstrated a significant reduction in lipid values. Atorvastatin modestly increased the levels of adiponectin (6.85 μg/mL to 8.43 μg/mL; P=0.0602) and significantly decreased the levels of resistin (15.65 pg/mL to 10.09 pg/mL; P=0.022). None of the patients experienced adverse events. CONClUSION: Our results demonstrate that atorvastatin significantly reduced the levels of resistin and induced a modest increase in adiponectin levels. This may, in part, explain the cardiovascular effects observed with statins in diabetic patients.

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Correlation between Levels of Circulating Adipokines and Adiponectin/Resistin Index with Carotid Intima-Media Thickness in Hypertensive Type 2 Diabetic Patients

Cited by 27 publications

References 24 publications

The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

Diabetic nephropathy and inflammation

Effect of atorvastatin on circulating adipocytokine levels in diabetic patients

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