Impact of Thyroid Hormones on Serum Prostate Specific Antigen Level in Patients with Benign Thyroid Disorders

Senel, Cagdas; Tuncel, Altuğ; Aslan, Yılmaz; Berker, Dilek; Çatak, Merve; Güler, Serdar; Balcı, Melih

doi:10.4274/jus.galenos.2020.3388

Cited by 2 publications

(1 citation statement)

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“…A positive correlation between prostate volume and elevated levels of free T3-T4 was similarly found in a study by Lee and colleagues (80); moreover, TSH seems to be negatively correlated with prostate size, improving the scores related to the lower urinary tract symptoms, which were even more evident when BPH patients were treated with dutasteride, an inhibitor of the local conversion of testosterone to DHT (81). A surrogate data was similarly found by Senel et al who reported, in a small study involving 50 patients, how decreased TSH and increased serum T3 and T4 were associated with increased PSA levels (82). As a result, the complex crosstalk between the thyroid and prostate, despite still obscure and fragmentary, should be further analyzed in a multidisciplinary manner, in order to integrate those data into the clinical practice of BPH treatment and management.…”

Section: The Clinical Point Of Viewmentioning

confidence: 85%

The androgen-thyroid hormone crosstalk in prostate cancer and the clinical implications

Torabinejad

Miro

Barone

et al. 2023

European Thyroid Journal

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There is increasing evidence that thyroid hormones (THs) work in an integrative fashion with androgen receptors (ARs) to regulate gonadal differentiation and reproductive function. Studies reveal that THs have interactions with the AR promoter region and increase AR expression. THs also have a role in the regulation of enzymes involved in the biosynthesis of androgens, such as 5α-reductase, which is essential in the conversion of testosterone into its active form, 5α-dihydrotestosterone. Additionally, the presence of androgen response elements (AREs) in the promoter regions of TH-related genes, such as deiodinases and thyroid hormone receptor isoforms have been identified in some vertebrates, indicating a mutual interaction between THs and ARs. Since the androgen signaling pathway, mediated by ARs, plays a key role in the formation and progression of prostate cancer (PCa), the existence of crosstalk between THs and ARs supports the epidemiologic and experimental evidence indicating a relationship between the high incidence of Prostate Cancer (PCa) and hyperthyroidism. This article aims to review the role of androgen-thyroid hormone crosstalk in PCa and its implication in the clinical management. As life expectancy is growing these days, it can increase the number of patients with PCa and the critical relevance of the disease. In order to gain better knowledge about PCa and to improve the clinical management, it is essential to get better insight into the key factors related to the formation and progression of this cancer.

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Section: The Clinical Point Of Viewmentioning

confidence: 85%