Impact of the use of Ethanolic Extract of Propolis, Flavonoid and Non-Flavonoid Propolis for Direct Pulp Capping in Collagen Type I Density

Sabir, Ardo; Mooduto, Latief; Kaelan, Cahyono; Horax, Sherly

doi:10.20396/bjos.v15i4.8650037

Cited by 10 publications

(9 citation statements)

References 23 publications

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“…Pulp capping treatment is defined as the materials used to make a protective layer on open dental pulp to allow the tissue to recover and maintain its normal function and vitality [1]. One commonly used material for pulp capping is calcium hydroxide (Ca(OH)2), which can terminate microorganisms because of its high pH and can stimulate fibroblast formation and the growth of tertiary dentin to be re-mineralised [2], [3]. Several studies also showed that Ca(OH)2 has deficiencies that can cause inflammation and necrosis on a pulp surface after capping due to its inability to adapt to dentin.…”

Section: Bioviability Of Beta-tricalcium Phosphate Nanoencapsulation ...mentioning

confidence: 99%

Bioviability of Beta-Tricalcium Phosphate Nanoencapsulation from Synthesis of Anadara granosa Shells on Fibroblast Cell Line BHK-21 Cell Culture

Kunarti

Budhy

Sari

2022

IJIE

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The purpose of this research is to measure the toxicity of beta-tricalcium phosphate (β-TCP) nanoencapsulation resulting from 18 hours of hydrothermal process on Anadara granosa (A. granosa) shell and 3 hours of sintering. The encapsulation process was carried out to reduce the side and toxic effect, as well as to inhibit the speed of calcium solubility, which can prevent the tunnel effects. The result of cell viability data that analysed using the one-way ANOVA statistical test showed there was no significant difference between the A. granosa shell encapsulation processes with treatment groups of 1, 2, 3, 4, 5, and 6 hours. The highest viability occurred in treatment group 2, with the A. granosa shell encapsulation stirred process of 2 hours. Therefore, the A. granosa clam shell nanoencapsulation was proved to be non-toxic and can be used in dentistry therapy

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Section: Bioviability Of Beta-tricalcium Phosphate Nanoencapsulation ...mentioning

confidence: 99%

Bioviability of Beta-Tricalcium Phosphate Nanoencapsulation from Synthesis of Anadara granosa Shells on Fibroblast Cell Line BHK-21 Cell Culture

Kunarti

Budhy

Sari

2022

IJIE

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“…Propolis has also been used for a long time as a traditional medicine because some active ingredients, such as flavonoids, terpenoids, saponins, caffeic acid penethyl esters (CAPE), etc. it can be as antibacterial, anti-inflammatory, and immunomodulatory 11 . Propolis has been shown to rarely cause allergic reactions and is not toxic 12 .…”

Section: Back Groundmentioning

confidence: 99%

Antibacterical Potency of Calcium Hydroxide and Propolis Mixture on Mixed Bacteria of Carious Dentin

Effendy

Ariesta

Saraswati

2019

CDJ

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Background: Calcium hydroxide has been known as the gold standard of pulp capping process, but still has some weaknesses such as a pH that is too high to be potentially toxic, resistant to certain bacteria, causing necrosis of the pulp, and causing a tunnel defect. This weakness causes researchers to look for alternative ingredients that have antibacterical properties that can be combined with calcium hydroxide. Propolis has antibacterial properties such as flavonoids, tannins, saponins, and terpenoids which can work as the best carrier that allows dissociation of ions from calcium hydroxide so the combination of both that has antibacterial power is expected to have an effective antibacterial potency against the number of bacterial colonization with mixed dentine carious. Aims: This study aims to determine the antibacterial potency produced by a combination of calcium hydroxide and propolis against mixed bacteria of carious dentine. Methods: The research was carried out using 4 treatment groups with each of 7 samples. Group I is a combination of calcium hydroxide and propolis with a ratio of 1: 1, group 2 with a ratio of 1: 1.5, group 3 with a ratio of 1: 2, and a positive control group. Each sample was put into a suspense of mixed bacteria of carious dentine, grown for 24 hours. Suspense is vortexed for 1 minute so the solution becomes homogeneous. Put 0.1 ml of suspended mixed bacteria of dentine carious from BHIB media, grown for 24 hours on MHA media and counted the number of colonies. Results: The highest number of colonies in the positive control group, then group 1, group 2, and the least number of colonies in group 3 with the most extract of propolis. Conclusion: The combination of calcium hydroxide and propolis with a ratio of 1: 2 has the best antibacterial power in inhibiting colonization of mixed bacteria of carious dentine.

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“…2 There are a number of studies documenting the biological functions of propolis, its extracts and constituents. 3 Several phamocological actitivities have been described for propolis, including antibacterial, 4 anti-inflammatory, 5 accelerated wound healing 6 and immunomodulatory. 7 Among of its constituents, both flavonoid and non-flavonoid substances of propolis also showed anti-bacterial 8 and anti-inflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

Indonesian propolis suppressed the expression of COX-2 in inflamed rat dental pulp in direct capping treatment

Sabir¹

2019

J Dentomaxillofac Sci

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Objective:The aim of the present study ass to analysis the expression COX-2 on inflamed rat dental pulp after capped with propolis. Material and Methods: Propolis was obtained from South Sulawesi, Indonesia. Flavonoid and non-flavonoid were purified from an ethanolic extract of propolis (EEP). Eighty male Sprague Dawley rats were divided randomly into 5 groups, each group consisting of 16 rats. Group I as a negative control, rats were left without any treatment. A Class I cavity was prepared on the occlusal surface of permanent maxillary right first molar. Dental pulp was exposed and allowed in oral environment for 1 hour, then capping with EEP (group II), flavonoid propolis (group III), non-flavonoid propolis (group IV), or calcium hydroxide (Ca(OH)2) (group V). All cavities were filled with glass ionomer cement. The animals were sacrificed at 6 hours, 2, 4 or 7 days after treatment, biopsy samples were obtained, processed for immunostaining of COX-2 and viewed under light microscope. Data was statistically analyzed using Friedman and Kruskal-Wallis tests with significant level P<0.05 biopsy samples were obtained, processed for immunostaining of COX-2 and viewed under light microscope. Data was statistically analyzed using Friedman and Kruskal-Wallis tests with significant level P<0.05 Results: Except in group I, COX-2 expression was decreased in all treatment group with the longer of observation time periods. In group II and group V, COX-2 expression was weaker than group III and IV at all periods time. However, there was no statistically significant differences of COX-2 expression among groups for each time period. Conclusion:The present study suggests that EEP and Ca(OH)2 were stronger than other materials test to suppressed COX-2 expression on inflamed rat dental pulp.

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Impact of the use of Ethanolic Extract of Propolis, Flavonoid and Non-Flavonoid Propolis for Direct Pulp Capping in Collagen Type I Density

Cited by 10 publications

References 23 publications

Bioviability of Beta-Tricalcium Phosphate Nanoencapsulation from Synthesis of Anadara granosa Shells on Fibroblast Cell Line BHK-21 Cell Culture

Bioviability of Beta-Tricalcium Phosphate Nanoencapsulation from Synthesis of Anadara granosa Shells on Fibroblast Cell Line BHK-21 Cell Culture

Antibacterical Potency of Calcium Hydroxide and Propolis Mixture on Mixed Bacteria of Carious Dentin

Indonesian propolis suppressed the expression of COX-2 in inflamed rat dental pulp in direct capping treatment

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