Impact of the post-weaning nutritional history on the response to an experimental Haemonchus contortus infection in Creole goats and Black Belly sheep

Ceï, Willy; Salah, Nizar Ben; Paut, C.; Dumoulin, P. J.; Arquet, Rémy; Felicite, Yoann; Guy, Alexandre; Archimède, Harry; Bambou, Jean-Christophe

doi:10.1016/j.vetpar.2016.01.015

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Recently, polymorphonuclear neutrophils and eosinophils have been described as essential host effectors involved in the mechanisms that limit the establishment of H. contortus [ 30 ]. In contrast to sheep, several studies conducted in goats have not found a direct relationship between blood eosinophilia and the level of parasitism [ 31 , 32 , 33 ]. Indeed, it has been suggested that the eosinophil response to Teladorsagia circumcincta would be less effective in goats compared to sheep [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Supplementation with Rumen-Protected Methionine Reduced the Parasitic Effect of Haemonchus contortus in Goats

Montout,

Bahloul,

Feuillet

et al. 2023

Veterinary Sciences

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The present study investigated the impact of rumen-protected (RP) methionine supplementation on the resistance and resilience to Haemonchus contortus experimental infection of goat kids. Twenty-seven 6-month-old goat kids (14.55 ± 2.7 kg body weight) were placed in individual pens during an experimental period of forty-two days. Each kid was placed under one of three distinct diets (n = 9 animals/diet) corresponding to the following experimental groups: Control (C, Hay + concentrate), Low Methionine (LM, Hay + concentrate + 3.5 g/Kg of Dry Matter (DM) of RP methionine, or High Methionine (HM, Hay + concentrate + 11.5 g/Kg of DM of RP methionine). After a 4-week period of adaptation to the diets, all the animals were experimentally infected with a single oral dose of 10,000 H. contortus third-stage infective larvae (L3). No significant effect of RP methionine supplementation was observed for feed intake, digestibility and growth performance. The faecal egg counts (FEC) and worm burdens were not impacted by RP methionine supplementation either. In contrast, Packed cell volume (PCV) and haemoglobin concentration were higher in kids supplemented with RP methionine. Similarly, the level of serum IgA directed against adult H. contortus excretion and secretion products (ESP) was higher in supplemented kids. These results suggested that RP methionine supplementation improved goat kids’ resilience against H. contortus infection.

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Section: Discussionmentioning

confidence: 99%

Supplementation with Rumen-Protected Methionine Reduced the Parasitic Effect of Haemonchus contortus in Goats

Montout,

Bahloul,

Feuillet

et al. 2023

Veterinary Sciences

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The energetic costs of sub‐lethal helminth parasites in mammals: a meta‐analysis

et al. 2022

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Parasites, by definition, have a negative effect on their host. However, in wild mammal health and conservation research, sub-lethal infections are commonly assumed to have negligible health effects unless parasites are present in overwhelming numbers. Here, we propose a definition for host health in mammals that includes sub-lethal effects of parasites on the host's capacity to adapt to the environment and maintain homeostasis. We synthesized the growing number of studies on helminth parasites in mammals to assess evidence for the relative magnitude of sub-lethal effects of infection across mammal taxa based on this expanded definition. Specifically, we develop and apply a framework for organizing disparate metrics of parasite effects on host health and body condition according to their impact on an animal's energetic condition, defined as the energetic burden of pathogens on host physiological and behavioural functions that relate directly to fitness. Applying this framework within a global meta-analysis of helminth parasites in wild, laboratory and domestic mammal hosts produced 142 peer-reviewed studies documenting 599 infection-condition effects. Analysing these data within a multiple working hypotheses framework allowed us to evaluate the relative weighted contribution of methodological (study design, sampling protocol, parasite quantification methods) and biological (phylogenetic relationships and host/parasite life history) moderators to variation in the magnitude of health effects. We found consistently strong negative effects of infection on host energetic condition across taxonomic groups, with unusually low heterogeneity in effect sizes when compared with other ecological meta-analyses. Observed effect size was significantly lower within crosssectional studies (i.e. observational studies that investigated a sub-set of a population at a single point in time), the most prevalent methodology. Furthermore, opportunistic sampling led to a weaker negative effect compared to proactive sampling. In the model of host taxonomic group, the effect of infection on energetic condition in carnivores was not significant. However, when sampling method was included, it explained substantial inter-study variance; proactive sampling showing a strongly significant negative effect while opportunistic sampling detected only a weak, non-significant effect. This may partly underlie previous assumptions that sub-lethal parasites do not have significant effects on host health. We recommend future studies adopt energetic condition as the framework for assessing parasite effects on wildlife health and provide guidelines for the selection of research protocols, health proxies, and relating infection to fitness.

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Physiological, immunological and genetic factors in the resistance and susceptibility to gastrointestinal nematodes of sheep in the peripartum period: A review

2021

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Summary Parasitic diseases of sheep involving gastrointestinal nematodes (GIN) are one of the main problems that affect fl ock productivity, especially during the peripartum period. Around lambing, the ewes are immunosuppressed and the nematode faecal egg count (FEC) increases at four weeks before lambing, reaching a peak between the fourth and sixth week postpartum and subsequently decreasing towards weaning. Prolactin has been credited with a suppressive effect on immune system, along with other hormones that intervene in metabolism, such as leptin, which has an important role in the activation of other hormones. Cortisol has also been included; this is stimulated by any stressful event and inhibits the proliferation of T-cells and alters the function of immunoglobulins. Another related hormone is pepsinogen, which is considered a marker of the integrity of the abomasum mucosa, as well as the albumin concentration that increases in the presence of a GIN infection. The humoral and cellular immune response, as well as inflammatory reactions, are the main mechanisms of action against GIN. Lymphocytes direct the effector mechanisms in a Th2 cell response, including interleukins (IL-4, IL-5, IL-9, IL-10) and transforming growth factor beta (TGF-β) together with immunoglobulins (IgA, IgG, IgM and IgE), which prevent the invasion of pathogens. Eosinophils with a cytotoxic effect are indicators of a parasitic infection, with importance in the immune protection of infected individuals. The genetic selection of resistant individuals measured by FEC is dependent on the heritability (h2), which is moderately inheritable and highly repeatable. Effects that influence the resistance or susceptibility of sheep to GIN infections in the peripartum period are determined by the interaction of various factors, such as genotype or breed, nutrition, age, type of birth, season and production system, etc., which are studied in this review.

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Impact of the post-weaning nutritional history on the response to an experimental Haemonchus contortus infection in Creole goats and Black Belly sheep

Cited by 3 publications

References 28 publications

Supplementation with Rumen-Protected Methionine Reduced the Parasitic Effect of Haemonchus contortus in Goats

Supplementation with Rumen-Protected Methionine Reduced the Parasitic Effect of Haemonchus contortus in Goats

The energetic costs of sub‐lethal helminth parasites in mammals: a meta‐analysis

Physiological, immunological and genetic factors in the resistance and susceptibility to gastrointestinal nematodes of sheep in the peripartum period: A review

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