Impact of the Morphologic Characteristics of Optic Disc on Choroidal Thickness in Young Myopic Patients

Chen, Qiuying; He, Jiangnan; Yao, Yin; Zhou, Hongfeng; Jiang, Huifen; Zhu, Jianfeng; Ohno‐Matsui, Kyoko; Zou, Haidong; Fan, Ying; Xu, Xun

doi:10.1167/iovs.18-26393

Cited by 43 publications

(52 citation statements)

References 40 publications

(39 reference statements)

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“…8,23 A recent study by our team suggested that PPA area in young patients with high myopia correlated significantly and negatively with pChT and mChT, even in early myopic stages. 15 The present study found that BMOD and BTA were more sensitive independent factors associated with mChT compared with PPA area (Table 3), and BTA could be a more sensitive independent factor associated with pChT ( Table 4).…”

Section: Discussionsupporting

confidence: 49%

“…The protocol for this cross-sectional study was consistent with those of previous studies. 15,27 The systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the students were measured. The mean arterial pressure (MAP) was calculated using the following formula: (SBP + 2 × DBP)/3.…”

Section: Methodsmentioning

confidence: 99%

“…In the macular region, all nine sectors of the grid were applied to analyze the average thickness; however, in the parapapillary area, only four regions of the outer circle were used to calculate the average thickness because no choroidal tissue was found in the central and inner circles, and the topographic maps were not reliable in these regions. 15,28 Retinal thickness was defined as the vertical distance between the internal limiting membrane (ILM) and the interface between the photoreceptor outer segments and retinal pigment epithelium. The RNFL thickness was defined as the vertical distance between the ILM and the interface between the nerve fiber layer and the ganglion cell layer.…”

Section: Ss-oct Imagingmentioning

confidence: 99%

“…Recently, Chen et al, 15 using fundus photography, found that peripapillary atrophy (PPA) area was negatively associated with macular choroidal thickness (mChT) and peripapillary choroidal thickness (pChT), whereas tilt ratio was positively associated with mChT and negatively associated with pChT. These results indicate that myopic optic disc characteristics are associated with choroidal thinning, which is further associated with myopic chorioretinal features.…”

mentioning

confidence: 96%

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Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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This study aimed to explore the morphological characteristics of Bruch's membrane opening distance (BMOD), border length (BL), border tissue angle (BTA), vertical tilt angle, and peripapillary atrophy (PPA), as well as their associations with choroidal thickness (ChT) in young healthy highly myopic eyes. METHODS. A total of 167 patients with high myopia and 172 individuals without high myopia were enrolled. All of the subjects were divided by axial length. The PPA area was measured on fundus photographs. BMOD, BL, BTA, vertical tilt angle, macular ChT (mChT), and peripapillary ChT (pChT) were measured on swept-source optical coherence tomography scans. RESULTS. The PPA area (P < 0.0001) and vertical tilt angle (P < 0.0001) were larger, BMOD (P < 0.0001) and BL (P < 0.0001) were longer, and BTA (P < 0.0001) was smaller in the high-myopia group compared with the group without high myopia. Every 1-μm increase in BMOD was associated with a 35.80-μm decrease in mChT; every 1°decrease in BTA was correlated with a 0.32-μm decrease in mChT and a 0.26-μm decrease in pChT; and no association was found between PPA area and ChT in the multivariate linear regression model. CONCLUSIONS. PPA area, BL, BMOD, and vertical tilt angle increased, but BTA decreased with axial elongation of the globe in young, healthy patients with myopia. Longer BMOD was positively correlated with lower mChT, and smaller BTA was positively correlated with lower mChT and pChT in this population.

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Section: Discussionsupporting

confidence: 49%

Section: Methodsmentioning

confidence: 99%

Section: Ss-oct Imagingmentioning

confidence: 99%

mentioning

confidence: 96%

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Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…All subjects have understood the study protocol and signed informed consent forms. The protocol was consistent with those of previous studies ( 20 , 21 ).…”

Section: Methodssupporting

confidence: 70%

Imaging Features by Machine Learning for Quantification of Optic Disc Changes and Impact on Choroidal Thickness in Young Myopic Patients

Sun

Chen

et al. 2021

Front. Med.

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Purpose: To construct quantifiable models of imaging features by machine learning describing early changes of optic disc and peripapillary region, and to explore their performance as early indicators for choroidal thickness (ChT) in young myopic patients.Methods: Eight hundred and ninety six subjects were enrolled. Imaging features were extracted from fundus photographs. Macular ChT (mChT) and peripapillary ChT (pChT) were measured on swept-source optical coherence tomography scans. All participants were divided randomly into training (70%) and test (30%) sets. Imaging features correlated with ChT were selected by LASSO regression and combined into new indicators of optic disc (IODs) for mChT (IOD_mChT) and for pChT (IOD_pChT) by multivariate regression models in the training set. The performance of IODs was evaluated in the test set.Results: A significant correlation between IOD_mChT and mChT (r = 0.650, R2 = 0.423, P < 0.001) was found in the test set. IOD_mChT was negatively associated with axial length (AL) (r = −0.562, P < 0.001) and peripapillary atrophy (PPA) area (r = −0.738, P < 0.001) and positively associated with ovality index (r = 0.503, P < 0.001) and torsion angle (r = 0.242, P < 0.001) in the test set. Every 1 × 10 μm decrease in IOD_mChT was associated with an 8.87 μm decrease in mChT. A significant correlation between IOD_pChT and pChT (r = 0.576, R2 = 0.331, P < 0.001) was found in the test set. IOD_pChT was negatively associated with AL (r = −0.478, P < 0.001) and PPA area (r = −0.651, P < 0.001) and positively associated with ovality index (r = 0.285, P < 0.001) and torsion angle (r = 0.180, P < 0.001) in the test set. Every 1 × 10 μm decrease in IOD_pChT was associated with a 9.64 μm decrease in pChT.Conclusions: The study introduced a machine learning approach to acquire imaging information of early changes of optic disc and peripapillary region and constructed quantitative models significantly correlated with choroidal thickness. The objective models from fundus photographs represented a new approach that offset limitations of human annotation and could be applied in other areas of fundus diseases.

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Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes

Nie

Ouyang

Tang

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Objective To investigate the microvasculature and structural characteristics of the eyes of myopic patients and their association with posterior staphyloma (PS). Methods This was a retrospective, case-control study comprising of 106 eyes from 72 individuals. Using 1:1 matching of axial length (AL) of their eyes, patients were allocated into a PS group or no posterior staphyloma (NPS) group. All patients were examined using ultra-widefield fundus imaging, optical coherence tomography angiography, and ocular biometry to acquire microvasculature and microstructure parameters. Results The anterior chamber depth (ACD) of the PS group was significantly different from that of the NPS group (3.56 mm vs 3.76 mm, P < 0.001), as was 1ens thickness (3.72 mm vs 3.57 mm, P = 0.005) and spherical equivalent (SE)(-10.11D vs -8.80D, P = 0.014). The PS group had reduced choriocapillaris flow, subfoveal choroidal thickness (SFCT), and a thinner retinal layer compared with the NPS group. No difference in retinal blood flow between the two groups was observed. The PS group exhibited a smaller disc area (15082.89 vs 17,043.32, P = 0.003) and angle α between temporal retinal arterial vascular arcades (113.29°vs 128.39°, P = 0.003), a larger disc tilt ratio (1.41 vs 1.24, P < 0.001) and parapapillary atrophy (PPA) area (13840.98 vs 8753.86, P = 0.020), compared with the NPS group. Multivariate regression analysis indicated that disc tilt ratio (P = 0.031) and SFCT (P = 0.015) were significant predictors of PS. In addition, PS (P = 0.049), AL (P = 0.003), corneal refractive power (P < 0.001), ACD (P = 0.022), relative lens position (P = 0.045), and disc area (P = 0.011) were significant predictors of SE. Conclusions PS was found to be closely linked to a reduction in choriocapillaris perfusion and anatomical abnormalities including posterior and anterior segments. Furthermore, PS exacerbated the progression of myopia.

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Impact of the Morphologic Characteristics of Optic Disc on Choroidal Thickness in Young Myopic Patients

Abstract: Citation: Chen Q, He J, Yin Y, et al. Impact of the morphologic characteristics of optic disc on choroidal thickness in young myopic patients. Invest Ophthalmol Vis Sci.

Cited by 43 publications

References 40 publications

Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia

Morphological Characteristics of the Optic Nerve Head and Choroidal Thickness in High Myopia

Imaging Features by Machine Learning for Quantification of Optic Disc Changes and Impact on Choroidal Thickness in Young Myopic Patients

Posterior staphyloma is associated with the microvasculature and microstructure of myopic eyes

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