Impact of the COVID-19 Pandemic on Diagnostic Frequency of Febrile Seizures: An Electronic Health Record Database Observational Study

Cadet, Katsiah; Ceneviva, Gary D.; Walter, Vonn; Thomas, Neal J.; Krawiec, Conrad

doi:10.1177/19418744221123208

Cited by 5 publications

(2 citation statements)

References 26 publications

(29 reference statements)

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“…Data privacy, security, attestation, and steps taken to ensure de-identification have been previously described. 12,13…”

Section: Methodsmentioning

confidence: 99%

Impact of the COVID-19 Pandemic on the Diagnostic Frequency and Medical Therapies Applied to Subjects With Functional Seizures

Schaefer Bennett,

Naik,

Krawiec

2024

The Neurohospitalist

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Background and Purposes The coronavirus 2019 (COVID-19) pandemic was associated with catastrophic consequences and increased psychological distress. However, it is unknown if the pandemic impacted the frequency of functional seizures (FS), a well known manifestation of psychiatric disease. The study objectives are to evaluate FS diagnostic code frequency before and during the COVID-19 pandemic and the therapies applied. We hypothesized that FS frequency would be higher during the pandemic, but that the therapies applied would be similar between the two time periods. Methods This was a retrospective observational cohort study utilizing the TriNetX ® electronic health record (EHR) database. We included subjects aged 8 to 65 years with a diagnostic code of “conversion disorder with seizures or convulsions.” After the query, the study population was divided into 2 groups [pre-COVID-19 (3/1/2018 to 2/29/2020) and COVID-19 (3/1/2020 to 2/28/2022). We analyzed subject demographics, diagnostic, procedure, and medication codes. Results We included 8680 subjects [5029 (57.9%) pre-COVID-19 and 3651 (42.1%) COVID-19] in this study. There was a higher odds of mental health conditions, anxiolytic prescription, emergency department services, and hospital services, but a lower odds of critical care services during COVID-19. There was no difference in antiepileptic use between the time periods. Conclusions During the COVID-19 pandemic, a higher odds of anxiolytic use, need for emergency department services, and hospital services was reported. In addition, there was a decreased odds of critical care services. This may reflect a change in how patients with FS were managed during the pandemic.

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“…Data privacy, security, attestation, and steps taken to ensure de-identification have been previously described. 12,13…”

Section: Methodsmentioning

confidence: 99%

Impact of the COVID-19 Pandemic on the Diagnostic Frequency and Medical Therapies Applied to Subjects With Functional Seizures

Schaefer Bennett,

Naik,

Krawiec

2024

The Neurohospitalist

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“…Although the incidence of seizures in children with fever during the COVID-19 pandemic has significantly increased ( Iijima et al, 2022 ; Joung et al, 2023 ), in the latest retrospective case-control study, the risk of FSs secondary to COVID-19 did not increase compared to other causes ( Hanlon et al, 2023 ). Meanwhile, a retrospective observational cohort study showed an increased frequency of complex FSs diagnoses during the COVID-19 pandemic ( Cadet et al, 2023 ). Further analysis of the clinical features of FSs in patients with and without COVID-19 revealed that patients with FSs in COVID-19 tended to be predominantly male and had a later age of onset compared with non-Covid-19 patients ( Seo et al, 2023 ).…”

Section: Introduction Of Febrile Seizuresmentioning

confidence: 99%

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

You

Chen

2023

Front. Cell Dev. Biol.

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Febrile seizures (FSs) are convulsions caused by a sudden increase in body temperature during a fever. FSs are one of the commonest presentations in young children, occurring in up to 4% of children between the ages of about 6 months and 5 years old. FSs not only endanger children’s health, cause panic and anxiety to families, but also have many adverse consequences. Both clinical and animal studies show that FSs have detrimental effects on neurodevelopment, that cause attention deficit hyperactivity disorder (ADHD), increased susceptibility to epilepsy, hippocampal sclerosis and cognitive decline during adulthood. However, the mechanisms of FSs in developmental abnormalities and disease occurrence during adulthood have not been determined. This article provides an overview of the association of FSs with neurodevelopmental outcomes, outlining both the underlying mechanisms and the possible appropriate clinical biomarkers, from histological changes to cellular molecular mechanisms. The hippocampus is the brain region most significantly altered after FSs, but the motor cortex and subcortical white matter may also be involved in the development disorders induced by FSs. The occurrence of multiple diseases after FSs may share common mechanisms, and the long-term role of inflammation and γ-aminobutyric acid (GABA) system are currently well studied.

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Case study: COVID-19 severity in diabetic patients with and without seizure

Baral,

Muduli,

Jakhmola

et al. 2024

International and Life Course Aspects of COVID-19

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Impact of the COVID-19 Pandemic on Diagnostic Frequency of Febrile Seizures: An Electronic Health Record Database Observational Study

Cited by 5 publications

References 26 publications

Impact of the COVID-19 Pandemic on the Diagnostic Frequency and Medical Therapies Applied to Subjects With Functional Seizures

Impact of the COVID-19 Pandemic on the Diagnostic Frequency and Medical Therapies Applied to Subjects With Functional Seizures

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms

Case study: COVID-19 severity in diabetic patients with and without seizure

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