Impact of the COVID-19 pandemic on the frequency of the pediatric rheumatic diseases

Akça, Ümmüşen Kaya; Atalay, Erdal; Cüceoğlu, Müşerref Kasap; Balık, Zeynep; Şener, Seher; Özsürekçi, Yasemin; Başaran, Özge; Batu, Ezgi Deniz; Bilginer, Yelda; Özen, Seza

doi:10.1007/s00296-021-05027-7

Cited by 18 publications

(18 citation statements)

References 25 publications

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“…A significant decrease in the incidence of HSP was found during the pandemic compared with the pre-COVID era [ 32 ]. The observed reduction in incidence is most likely due to the decreased spread of other cold viruses as a result of the precautionary measures (such as wearing masks, restriction of mass gatherings, lockdowns, and quarantine) for reducing virus transmission during the pandemic.…”

Section: Environment Microbial and Virus Infectionsmentioning

confidence: 99%

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Nikolaishvili

Pazhava

Lernia

2023

JCM

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Henoch–Schönlein purpura or IgA vasculitis is the most common type of pediatric vasculitis that may affect adults as well. It is classified as a type of small-vessel vasculitis. It can cause cutaneous and systemic symptoms with a minority of patients developing kidney failure. Little is known about the specific pathophysiology of this disorder, except that it is believed to occur in individuals with abnormally glycosylated IgA1. Serum aberrant IgA1 may form large antigen–antibody complexes which, due to a defective clearance, are able to deposit in the small vessels of the skin, kidney, gut, and joints. A variety of factors, including infectious agents, drugs, and vaccines, have been identified as potential triggers. The majority of cases are preceded by upper respiratory tract infections, and seasonal variations suggest a link with many pathogens. The etiologic agent most frequently associated with IgA vasculitis historically have been group A β-hemolytic streptococcus and common respiratory tract viruses. However, during the current coronavirus pandemic, SARS-CoV-2 infection was identified as a main trigger factor. In addition, IgA vasculitis has been observed following COVID-19 immunization. This review provides insights into the state of the art on the relationship between viral infections, viral vaccines, and Henoch–Schönlein purpura.

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Section: Environment Microbial and Virus Infectionsmentioning

confidence: 99%

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Nikolaishvili

Pazhava

Lernia

2023

JCM

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“…However, limited evidence suggests a decreased incidence of Henoch-Schönlein vasculitis in childhood [ 77 ]. [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although Henoch-Schönlein vasculitis mostly affects children [ 1 ], Henoch-Schönlein patients included in this survey were frequently adult. This likely results from publication bias and from the fact that COVID-19 rarely affects children and that this age group infrequently gets vaccinated against SARS-CoV-2 [ 76 , 79 ].…”

Section: Discussionmentioning

confidence: 99%

Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review

Bronz¹,

Faré²,

Lava³

et al. 2022

Journal of Autoimmunity

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“… 14 - 18 On the other hand, a decrease in the diagnosis rate of some rheumatological diseases such as acute rheumatic fever, IgA vasculitis, classic Kawasaki disease, and macrophage activation syndrome was reported in the pandemic period compared to previous years. 19 The COVID-19 pandemic had a significant impact on pediatric rheumatology practice.…”

Section: Introductionmentioning

confidence: 99%

Patients Without a Rheumatic Disease Diagnosis in a Pediatric Rheumatology Unit: Retrospective Analysis and Comparison Between Pre-pandemic and Pandemic Periods

Akça

Batu

Tanalı

et al. 2023

Turk Arch Pediatrics

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Objective: Children with suspicious complaints of rheumatic diseases are generally referred to a pediatric rheumatologist. We aimed to evaluate the profile of patients referred to the pediatric rheumatology unit and were not diagnosed with a rheumatic disease and to assess the impact of the coronavirus disease-2019 pandemic on referral complaints. Materials and Methods: All new outpatients who applied to the pediatric rheumatology department between March 2019 and February 2021 and were not diagnosed with rheumatic disease were included. We also compared the frequency of admission symptoms during the pre-pandemic (March 2019-February 2020) and pandemic periods (March 2020-February 2021). Results: A total of 1089 patients without a rheumatic disease diagnosis (568 female, 52.2%; median age 10.0 years) were included in this study. The most common complaint for referral was prolonged or recurrent fevers (13.4%) followed by anti-nuclear antibody positivity (13.1%), arthralgia (13.0%), skin findings (7.5%), and the presence of heterozygous mutations in the Mediterranean fever gene (6.9%). During the pandemic year, the number of patients referred for back pain increased significantly ( P = .028). A total of 682 of 1089 patients were consulted from other departments in our center (62.6%). Of these, the most frequent consultation request was from general pediatrics (43.6%). The rheumatic disease was excluded in 11.3% of the patients. Conclusion: Prolonged or recurrent fever and anti-nuclear antibody positivity were the most frequent complaints of referrals to a pediatric rheumatology unit in patients who did not have a rheumatic disease. The rate of back pain was more common in children during the pandemic period.

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Impact of the COVID-19 pandemic on the frequency of the pediatric rheumatic diseases

Cited by 18 publications

References 25 publications

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Viral Infections May Be Associated with Henoch–Schönlein Purpura

Coronavirus disease 2019, vaccination against coronavirus and immunoglobulin A-mediated diseases: systematic literature review

Patients Without a Rheumatic Disease Diagnosis in a Pediatric Rheumatology Unit: Retrospective Analysis and Comparison Between Pre-pandemic and Pandemic Periods

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