Impact of the Charlson comorbidity index and prognostic nutritional index on prognosis in patients with early gastric cancer after endoscopic submucosal dissection

Iwai, Naoharu; Dohi, Osamu; Naito, Yuji; Inada, Yutaka; Fukui, Akifumi; Takayama, Shin; Ogita, Kazuyuki; Terasaki, Kei; Nakano, Takahiro; Ueda, Tomohiro; Okayama, Tetsuya; Yoshida, Naohisa; Katada, Kazuhiro; Kamada, Kazuhiro; Uchiyama, Kazuhiko; Ishikawa, Takeshi; Handa, Osamu; Takagi, Tomohisa; Konishi, Hideyuki; Yagi, Nobuaki; Itoh, Yoshito

doi:10.1111/den.13051

Cited by 55 publications

(58 citation statements)

References 25 publications

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“…However, a poorer prognosis is anticipated in patients with severe comorbidities even if successful treatment is achieved. Recently, results similar to ours were reported [8,10,11]. One multicenter retrospective cohort study [8], using propensity score analysis, demonstrated that 5-year overall survival rates of patients with liver cirrhosis was 60.0%, which was significantly lower than that of patients without liver cirrhosis (91.0%).…”

Section: Discussionsupporting

confidence: 84%

“…In addition, ESD has also been performed on patients with severe comorbidities, such as liver cirrhosis or renal dysfunction, as well as in elderly patients because it is less invasive [8,9]. Some studies [10,11] have also reported on the long-term outcome of gastric ESD for patients with severe comorbidities.…”

Section: Introductionmentioning

confidence: 99%

“…A previous study [10] reported that no significant difference regarding the long-term outcome of ESD for EGC was observed for ASA-PS groups 2 and 3 patients aged ≥ 85 years. Another study [11] reported that the prognosis of patients with severe comorbidities was poor, regardless of age. However, they were retrospective non-randomized studies, where baseline patient characteristics were not adjusted.…”

Section: Introductionmentioning

confidence: 99%

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Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis

et al. 2018

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Background Recently, endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) has been performed on patients with severe comorbidities because it is less invasive, although little is known regarding long-term outcomes. This study aimed to assess the long-term outcomes of ESD for patients with severe and non-severe comorbidities. Methods We enrolled 1081 patients who underwent ESD for EGC between February 2004 and June 2013. Based on the American Society of Anesthesiologists Physical Status (ASA-PS) classification, we defined patients with severe and nonsevere comorbidities as ASA-PS 3 and 1/2, respectively. We retrospectively compared the overall survival, risk factors for mortality, and adverse events between these two groups using propensity score matching and inverse probability of treatment weighting. Results A total of 488 patients met the eligibility criteria. After matching, the ASA-PS 3 group showed a significantly shorter survival than the ASA-PS 1/2 group (5-year overall survival rate, 79.1 vs. 87.7%; p < 0.01). In addition, only the ASA-PS 3 group had a significant risk factor for mortality using both the Cox analysis [hazard ratio (HR), 2.56; 95% confidence interval (CI) 1.18-5.52; p = 0.02] and the IPTW method (HR, 3.14; 95% CI 1.91-5.14; p < 0.01). There was no significant difference in adverse events after matching between the two groups (p = 0.21). Conclusions The long-term outcome of gastric ESD for patients with severe comorbidities was worse than for those with non-severe comorbidities. Further studies will be necessary to determine if ESD is truly warranted in these patients.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis

et al. 2018

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“…To identify risk factors for heart disease, including previous hypertension, diabetes, and dyslipidemia, we used algorithms (which were similar to previously reported algorithms in a study that used NHIS data) along with ICD‐10 codes (hypertension, I10‐I13 and I15; diabetes mellitus, E11‐E14; and dyslipidemia, E78) in combination with the electronic data interchange code of related medications . The Charlson Comorbidity Index was also evaluated with an ICD‐10 code . Lifestyle factors (eg, smoking and obesity) were not included in this analysis because the NHID does not provide this information.…”

Section: Methodsmentioning

confidence: 99%

“…13 The Charlson Comorbidity Index was also evaluated with an ICD-10 code. 16 Lifestyle factors (eg, smoking and obesity) were not included in this analysis because the NHID does not provide this information.…”

Section: Variables and Operational Definitionsmentioning

confidence: 99%

Long‐term risk of congestive heart failure in younger breast cancer survivors: A nationwide study by the SMARTSHIP group

Lee

Hur

Lee

et al. 2019

Cancer

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Background There is a controversy about late‐onset congestive heart failure (CHF) among breast cancer survivors. This study investigated the incidence rate and risk factors of late‐onset CHF more than 2 years after the breast cancer diagnosis. Methods A nationwide, retrospective study was conducted with the National Health Information Database. With 1:3 age‐ and sex‐matched noncancer controls, Cox proportional hazard regression models were used to analyze the incidence and risk factors of late CHF. The cumulative incidence rate of late CHF was evaluated with a Kaplan‐Meier analysis and a log‐rank test. Results A total of 91,227 cases (286,480 person‐years) and 273,681 controls (884,349 person‐years) were evaluated between January 2007 and December 2013. The risks of late CHF were higher in cases than controls (hazard ratio [HR], 1.396; 95% confidence interval [CI], 1.268‐1.538). Younger survivors (age ≤ 50 years) showed a higher risk of late CHF than their younger counterparts (HR, 2.903; 95% CI, 2.425‐3.474). Although older age was a risk factor for late CHF, older survivors (age ≥ 66 years) showed no difference in the risk of late CHF in comparison with their counterparts (HR, 0.906; 95% CI, 0.757‐1.084). Anthracyclines and taxanes were risk factors for late CHF, although trastuzumab, radiation, and endocrine therapy were not. Conclusions Young breast cancer survivors have a greater risk of late CHF than the young population without cancer. More attention should be paid to young breast cancer survivors who receive taxane‐ or anthracycline‐based regimens over the long term.

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Development and validation of pretreatment nomogram for disease‐specific mortality in gastric cancer‐A competing risk analysis

Bando

Kattan

et al. 2021

Cancer Medicine

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Impact of the Charlson comorbidity index and prognostic nutritional index on prognosis in patients with early gastric cancer after endoscopic submucosal dissection

Abstract: CCI and PNI can be prognostic indicators for non-elderly and elderly patients with EGC after ESD.

Cited by 55 publications

References 25 publications

Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis

Long-term outcome of endoscopic submucosal dissection for early gastric cancer in patients with severe comorbidities: a comparative propensity score analysis

Long‐term risk of congestive heart failure in younger breast cancer survivors: A nationwide study by the SMARTSHIP group

Development and validation of pretreatment nomogram for disease‐specific mortality in gastric cancer‐A competing risk analysis

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