Impact of Tetanus, Diphtheria, and Acellular Pertussis (Tdap) Vaccine Use in Wound Management on Health Care Costs and Pertussis Cases

Talbird, Sandra; Graham, Jonathan; Mauskopf, Josephine; Masseria, Cristina; Krishnarajah, Girishanthy

doi:10.18553/jmcp.2015.21.1.88

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…Vaccination is one of the most effective methods to prevent infectious diseases and manage healthcare costs 296 . Traditional vaccines have good immunogenicity due to the complex nature of the formulation and the presence of adjuvants.…”

Section: Medical Applications Of Agnpsmentioning

confidence: 99%

Silver nanoparticles: Synthesis, medical applications and biosafety

et al. 2020

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Silver nanoparticles (AgNPs) have been one of the most attractive nanomaterials in biomedicine due to their unique physicochemical properties. In this paper, we review the state-of-the-art advances of AgNPs in the synthesis methods, medical applications and biosafety of AgNPs. The synthesis methods of AgNPs include physical, chemical and biological routes. AgNPs are mainly used for antimicrobial and anticancer therapy, and also applied in the promotion of wound repair and bone healing, or as the vaccine adjuvant, anti-diabetic agent and biosensors. This review also summarizes the biological action mechanisms of AgNPs, which mainly involve the release of silver ions (Ag + ), generation of reactive oxygen species (ROS), destruction of membrane structure. Despite these therapeutic benefits, their biological safety problems such as potential toxicity on cells, tissue, and organs should be paid enough attention. Besides, we briefly introduce a new type of Ag particles smaller than AgNPs, silver Ångstrom (Å, 1 Å = 0.1 nm) particles (AgÅPs), which exhibit better biological activity and lower toxicity compared with AgNPs. Finally, we conclude the current challenges and point out the future development direction of AgNPs.

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Section: Medical Applications Of Agnpsmentioning

confidence: 99%

Silver nanoparticles: Synthesis, medical applications and biosafety

et al. 2020

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“…It has been predicted that replacing Td with Tdap for all indicated wounds would cost an additional $0.01-$0.03 per-member, per-month for health care plans when prevented pertussis cases are factored in. 13 It is out of the scope and feasibility of this study to quantify cost savings based on prevented cases of tetanus and pertussis. Although the decrease seen in duplicate vaccinations was not significant, any trend toward a reduction in duplicate vaccinations could contribute to an institutional cost savings.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Pharmacy-Driven Education on the Amount of Appropriately Administered Tetanus Vaccines in the Emergency Department

2018

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Background: Tetanus vaccinations for wound prophylaxis are routinely administered in emergency departments (ED). Current recommendations from the Centers for Disease Control and Prevention (CDC) and Advisory Committee on Immunization Practices (ACIP) regarding tetanus administration for wound prophylaxis differentiate between the tetanus and diphtheria (Td) and the tetanus, diphtheria, acellular pertussis (Tdap) formulations and when they should be administered. Lack of knowledge regarding these recommendations, different formulations, and techniques to locate patient immunization history can lend to increased duplicate and inappropriate vaccinations. Objective: The purpose of this prospective, interventional study with a historical control was to evaluate the impact of a pharmacy-driven education series on the proportion of duplicate and inappropriate tetanus vaccinations administered in a level I trauma center ED. Methods: Three months of tetanus vaccinations administered in the ED after this education were analyzed and compared with a historical control. The primary outcome is the percentage of vaccinations considered duplicates (previous vaccination within the past 5 years) when patients' medical record was reviewed for immunization history. Secondary end points include the percentage of vaccinations considered nonadherent (according to current CDC-ACIP guidelines), the total cost of all duplicate vaccinations, and the percentage of vaccination orders that had the wrong formulation administered. Results: The percentage of duplicate vaccinations decreased from 9.9% (25 vaccinations) to 5.5% (14 vaccinations) (P = .067) from the preintervention group to the postintervention group. Nonadherent vaccinations compiled 3.6% versus 2.8% of the vaccinations (P = .611) and incorrect formulations given were 18.2% versus 11.4% (P = .176) in the preintervention and postintervention groups, respectively. Conclusion: The study suggests that multiple formulations of tetanus vaccinations and fragmented documentation of immunizations increase the prevalence of medication errors related to tetanus vaccinations. It also indicates that interventions more enduring than education are required to prevent these errors.

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“…Only one study included adverse events following immunization (AEFI) in the model [14]. Although the evaluated vaccines seem reasonably safe, all vaccines can cause mild adverse events, such as fever or local reactions at the injection site (erythema, swelling and pain), in a small number of the vaccinees.…”

Section: Discussionmentioning

confidence: 99%