Impact of Synergistic Polymorphisms in Adrenergic Receptor-Related Genes and Cardiovascular Events in Patients With Dilated Cardiomyopathy

Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study

“…The observed minor Gly allele frequency (Gly389Arg + Gly389Gly) was 0.21, and no deviation from Hardy-Weinberg equilibrium was observed in the genotype distribution of Arg389Gly ( p = 0.75). The proportion of Gly carriers was lower than the reported proportion among blacks (range, 0.41 to 0.42) or whites (range, 0.27 to 0.28) [ 14 , 22 ]; however, the observed level was similar to the reported proportion among Japanese dilated cardiomyopathy patients (0.20) [ 23 ].…”

“…ADRB1 is encoded by an intron-less gene located on chromosome 10q24-26, consisting of a short 5’ untranslated region of 86 base pairs (bp), an open reading frame that encodes a protein of 477 amino acids, and a 3’ untranslated region of about 900 bp [ 24 ]. The allele frequency of ADRB1 Gly389 among Asians was reported to be in the range of 0.20 to 0.30, which is quite lower than those in Caucasians (range, 0.24 to 0.34) and African Americans (range, 0.39 to 0.46) [ 23 , 25 ]. The allele frequency of ADRB1 Gly389 observed in this study was 0.21, which is similar to a previous report in Asians.…”

Norepinephrine transporter function and human cardiovascular disease

“…Moreover, together with two distinct adrenoceptor genotypes the T182C genotype may negatively affect the outcome in dilated cardiomyopathy patients (94). Given the high prevalence of the T182C genotype (67), this finding might be of importance for a large number of heart failure patients.…”

Genetic polymorphisms associated with heart failure: A literature review

“…Combination ADRB1 and ADRB2 polymorphisms, such as Arg389/Ser49 , Arg16/Gln27 and Gly389Gly/Gly49Gly/Thr164Ile were found to confer lower HF-related mortality than other haplotypes. 115 – 117 In addition, Adamopoulos, et al . 96 showed that combination of the TGFB1+869 T/C and TGFB1+915 G/C genotypes was associated with worse cardiac function and adverse prognosis than other genotypes.…”