Norepinephrine transporter function and human cardiovascular disease

Schroeder, Christoph; Jordan, Jens

doi:10.1152/ajpheart.00492.2012

Cited by 82 publications

(65 citation statements)

References 129 publications

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“…To the contrary, agonists such as dexmedetomidine result in a decrease in noradrenaline release and synthesis (Gobert et al, 1998;Millan et al, 2000). Approximately 80-90% of the released noradrenaline is taken up again through the neuronal noradrenaline transporters located at the presynaptic cell membrane (Esler et al, 1990;Schroeder and Jordan, 2012). Therefore, noradrenaline transporters play an important role in the homeostasis of the noradrenaline system.…”

Section: Noradrenaline In the Brainmentioning

confidence: 99%

The role of adrenoceptors in the central nervous system in male and female rat sexual behavior

Snoeren

2015

European Journal of Pharmacology

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Three different phases can be distinguished in rats' sexual cycle, the introductory (precopulatory), the copulatory and the executive (ejaculatory) phases. In this review, a new analysis of existing pharmacological data is made, both in male and female rats, in which the different aspects of sexual behavior are taken into account. An effort is made to distinguish pharmacological effects on sexual behavior from a possible physiological role of noradrenaline. In addition, new data on the role of α2-adrenoceptors on female sexual behavior is presented. The new analysis suggests that noradrenaline has a stimulatory role on the executive phase of male sexual behavior, while the introductory and copulatory phases remain unaffected. Adrenoceptors play a role in the regulation of sexual behavior in the medial preoptic area and the lateral septum. In female rats, noradrenaline also does not play a vital role in the introductory phase. Only the lordosis behavior of the copulatory phase is sometimes affected by adrenergic agents, but only under a certain hormonal condition. The medial preoptic area, the ventromedial nucleus, the arcuate ventromedial nucleus and median eminence are involved in the regulation of female sexual behavior. The new data suggest that α2-adrenoceptors play no major role on any indices of female sexual behavior.

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Section: Noradrenaline In the Brainmentioning

confidence: 99%

The role of adrenoceptors in the central nervous system in male and female rat sexual behavior

Snoeren

2015

European Journal of Pharmacology

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“…7). Reduced norepinephrine transporter function observed in common heart diseases like congestive heart failure and stress induced cardio-myopathy may have an adverse effect on the heart [57].…”

Section: Impact Of Leptin On Cardiovascular Centermentioning

confidence: 99%

Neuro-endocrine immune networks leading to HIV-associated cardiovascular abnormalities: Role of leptin

et al. 2015

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a b s t r a c tPatients infected with human immunodeficiency virus exhibit many risk factors like atherosclerosis, endothelial dysfunction and hypertension for cardiovascular disease. As the homeostatic mechanisms in body are regulated by the integrated actions of cytokines and hormones, the normal function of a human heart is also governed by the neuro-endocrine immune interactions. Patients suffering from acquired immunodeficiency syndrome manifest alterations in the neural immune networks mediated by human immunodeficiency virus and leptin, which incline them to suffer from congestive heart failure. Networks that disrupt the cardiovascular functions are the focus of this review.

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“…The pharmacological activity of sibutramine as a nonselective neuronal norepinephrine transporter (NET) inhibitor suggests that reduced NET function could be responsible for the adverse effect on the cardiovascular system [125]. Pharmacological studies showed that the NET has opposing effects on cardiovascular sympathetic regulation in the brain and in the periphery [125].…”

Section: Sibutramine a Comparable Drug?mentioning

confidence: 99%

“…Pharmacological studies showed that the NET has opposing effects on cardiovascular sympathetic regulation in the brain and in the periphery [125]. Its function appears to be reduced in common heart diseases, whether as a consequence or cause is currently unclear [125]. There is also some evidence for the contribution of reduced neuronal NE reuptake to sympathetic activation in hypertension [126].…”

Section: Sibutramine a Comparable Drug?mentioning

confidence: 99%

Assessment of potential cardiovascular risks of methylphenidate in comparison with sibutramine: do we need a SCOUT (trial)?

Antel

Albayrak

Heusch³

et al. 2014

Eur Arch Psychiatry Clin Neurosci

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With the recent approval of methylphenidate (MPH) for treating attention-deficit/hyperactivity disorder (ADHD) in adults, the number of patients exposed will increase tremendously. The ongoing debate on the cardiovascular safety of MPH has triggered two large retrospective cohort studies in children and adolescents as well as in young to middle-aged adults. These studies looked into serious cardiovascular events (sudden cardiac death, acute myocardial infarction and stroke) as primary endpoints and concluded that MPH was safe after a mean duration of 2.1 years of follow-up in children and adolescents and mean duration of 0.33 years of current use in adults. The results are encouraging with respect to the short- and medium-term use of MPH. Without the inherent limitations of retrospective cohort studies, a prospective randomized, double-blind, placebo-controlled, multicenter trial in individuals stratified for cardiovascular risk factors would allow for an optimized risk assessment. With many millions of patients treated per year and drawing parallels to the lately discovered risks of sibutramine, another sympathomimetic with an overlapping mode of action and similar side effects on heart rate and blood pressure, we hypothesize that such a trial might be a dedicated risk mitigation strategy for public health. A critical assessment of cardiovascular side effects of MPH appears particularly warranted, because ADHD is associated with obesity, smoking and poor health in general. We summarize recent findings with the focus on cardiovascular risks of MPH in humans; we additionally analyze the limited number of rodent studies that have addressed cardiovascular risks of MPH.

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Norepinephrine transporter function and human cardiovascular disease

Abstract: Schroeder C, Jordan J. Norepinephrine transporter function and human cardiovascular disease.

Cited by 82 publications

References 129 publications

The role of adrenoceptors in the central nervous system in male and female rat sexual behavior

The role of adrenoceptors in the central nervous system in male and female rat sexual behavior

Neuro-endocrine immune networks leading to HIV-associated cardiovascular abnormalities: Role of leptin

Assessment of potential cardiovascular risks of methylphenidate in comparison with sibutramine: do we need a SCOUT (trial)?

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