Impact of sustained virologic response on quality of life in chronic HVC carriers

Daltro-Oliveira, Renato; Morais-de-Jesus, Mychelle; Pettersen, K.M.; Paraná, Raymundo

doi:10.1016/s1665-2681(19)31002-6

Cited by 16 publications

(7 citation statements)

References 29 publications

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“…. Our assumption was that better understanding of the psychosocial impact of this disease, knowledge of patients' psychosocial responses to treatment, and the use of psychological interventions would likely result in better patient outcomes over time . Our study of depression and physical health in these patients was guided, in part, by a “psychosocial‐stressor” model used in previous investigations .…”

Section: Discussionmentioning

confidence: 99%

Predictors of poor mental and physical health status among patients with chronic hepatitis C infection: The Chronic Hepatitis Cohort Study (CHeCS)

et al. 2015

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Aims Our objective was to assess the extent and risk factors for depression and poor physical health among patients with chronic hepatitis C virus (HCV) infection. Methods We surveyed HCV-infected patients seen at four large healthcare systems participating in the Chronic Hepatitis Cohort Study (CHeCS). Survey data included demographics, depression and physical health measures, substance use history, current social support, recent stressor exposures, and, from the electronic medical record, treatment history, and Charlson Comorbidity Index scores. Results There were 4,781 respondents, who were a mean of 57 years old, 71% White, and 57% male. Altogether, 51.4% reported past injection drug use, 33.9% were current smokers, and 17.7% had abused alcohol in the previous year. Additionally, 47.4% had been previously treated for HCV and 14.8% had a 12-week sustained viral response (SVR) following HCV therapy. Overall, 29.7% of patients met criteria for current depression and 24.6% were in poor physical health. In multivariate analyses, significant predictors of depression and poor health included: male gender (vs. female, OR, 0.70 and 0.81), Black race (vs. white, ORs, 0.60 and 0.61), having education less than high school (vs. college, ORs, 1.81 and 1.54), being employed (vs. not, ORs, 0.36 and 0.25), having high life stressors (vs. low, ORs, 2.44 and 1.64), having low social support (vs. high, ORs=2.78 and 1.40), and having high Charlson scores (vs. none, ORs=1.58 and 2.12). Achieving a 12- week SVR was found to be protective for depression. Conclusions This large survey of US HCV patients indicates the extent of adverse health behaviors and mental and physical comorbidities among these patients.

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Section: Discussionmentioning

confidence: 99%

Predictors of poor mental and physical health status among patients with chronic hepatitis C infection: The Chronic Hepatitis Cohort Study (CHeCS)

et al. 2015

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“…According to international guidelines of EASL the response to therapy with sofosbuvir is judged initially by the rapid virological response (RVR) that is the undetectable viral load on PCR done at one month while the ultimate goal is to get a sustained virological response (SVR) done after 12 weeks of completion of therapy. 14 International studies have shown that twelve weeks of treatment with Sofosbuvir in combination with peginterferon and ribavirin resulted in substantial decreases in the level of HCV RNA during therapy, leading to a sustained virologic response at 24 weeks after treatment in 92% of patients with HCV genotype 2 or 3 infection. 15 The same regimen of 12 weeks of treatment with sofosbuvir, peginterferon and ribavirin resulted in a sustained virologic response 24 weeks after treatment in 89% of patients with HCV genotype 1 infection 16 But all these statistics reflect the response rates in western population where the distribution of genotypes is different from that of Pakistani population.…”

Section: Introductionmentioning

confidence: 99%

Rapid and Early Virological Response of Patients Treated With Sofosbuvir in Chronic Hepatitis C.

Siddique¹,

Shoaib²,

Saad³

et al. 2017

Pak J Med Sci

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Objective:To determineRapid & End treatment response of patients treated with Sofosbuvir in Chronic Hepatitis C at tertiary care hospital.Methods:It was an observational study conducted at Memon Medical Institute from January 2016 to July 2017. The inclusion criteria for patients was 18 years of age or older, having chronic infection with HCV. Total=201 received sofosbuvir with or without interferon in our OPDs. Patients were categorized into Treatment naïve, treatment experienced and decompensated chronic liver disease. Pregnant patients and those not willing to participate were excluded. Initially genotyping and Quantitative HCV RNA test was done.Results:A total of 201 subjects were included in the study with mean age of the patients was 46.22± 14.41 years. Of 201 patients, n= 131 (65.2%) chronic hepatitis C, compensated cirrhosis n= 47(23.4%), and with decompensated cirrhosis n=23(11.4%). Most commonly genotype 3 n= 180 (89.6%) was present followed by genotype 1 n=9(4.5%), genotype 2 n=1(0.5%), genotype 4 n=1(0.5%). Of patients with genotype 3, 123 received dual therapy and 57 were given triple therapy. After one month of therapy HCV RNA by PCR, 200(99.5%) achieved RVR, 199(99%) achieved ETR and SVR achieved in 178(88.5%) while remaining 1 patient did not achieved RVR, 2 ETR and 12 patients did not achieved SVR and remaining 11 SVR lost follow up.Conclusion:Sofosbuvir has shown to be very effective andsuccessfulwith achievement of virological response with little or no resistance in all genotypes mainly genotype 3 treated in our study population. The promising results of our study will aid in better outcomes and therefore help in eradication of the virus.

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“…Evidence of HCV replication in the central nervous system [34,35] supports this hypothesis. HRQoL is also improved in patients who achieve sustained virological response after antiviral therapy [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C Virus Infection as a Traumatic Experience

et al. 2014

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ObjectiveThe purpose of this study was to evaluate whether individuals consider their HCV infection to be a potentially traumatic experience. Additionally, we investigated its association with Post-Traumatic Stress Disorder (PTSD) and the impact of PTSD diagnosis on health-related quality of life (HRQoL) in HCV infected subjects.MethodsWe conducted a cross-sectional survey of 127 HCV-infected outpatients recruited at a University Hospital in Salvador, Brazil. All subjects answered an orally-administered questionnaire to gather clinical and socio-demographic data. We investigated traumatic experiences and the subject's perception of the disease using the Trauma History Questionnaire. PTSD and other psychiatric diagnoses were assessed through the Mini International Neuropsychiatric Interview-Brazilian Version 5.0.0 (M.I.N.I. PLUS). HRQoL was assessed using Short-Form 36 (SF-36).ResultsApproximately 38.6% of the patients considered hepatitis C to be a traumatic experience. Of these, 60.7% had a PTSD diagnosis. PTSD was associated with significant impairment in quality of life for individuals in seven SF-36 domains as shown bymultivariate analysis: Role-Physical (β: −24.85; 95% CI: −42.08; −7.61), Bodily Pain (β: −19.36; 95% CI: −31.28; −7.45), General Health (β: −20.79; 95% CI: −29.65; −11.92), Vitality (β: −11.92; 95% CI: −20.74; −3.1), Social Functioning (β: −34.73; 95% CI: −46.79; −22.68), Role-Emotional (β: −26.07; 95% CI: −44.61; −7.53), Mental Health (β: −17.46; 95% CI: −24.38; −10.54).ConclusionHCV is frequently a traumatic experience and it is strongly associated with PTSD diagnosis. PTSD significantly impaired HRQoL.

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Impact of sustained virologic response on quality of life in chronic HVC carriers

Cited by 16 publications

References 29 publications

Predictors of poor mental and physical health status among patients with chronic hepatitis C infection: The Chronic Hepatitis Cohort Study (CHeCS)

Predictors of poor mental and physical health status among patients with chronic hepatitis C infection: The Chronic Hepatitis Cohort Study (CHeCS)

Rapid and Early Virological Response of Patients Treated With Sofosbuvir in Chronic Hepatitis C.

Hepatitis C Virus Infection as a Traumatic Experience

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