Impact of surface topography on the bacterial attachment to micro- and nano-patterned polymer films

Francone, Achille; Merino, S.; Retolaza, A.; Ramiro, J.; Alves, Sofia A.; Castro, Joana Vieira de; Neves, Nuno M.; Arana, Ainara; Marimón, José María; Torres, C. M. Sotomayor; Kehagias, N.

doi:10.1016/j.surfin.2021.101494

Cited by 21 publications

(14 citation statements)

References 49 publications

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“…D’Almeida et al covalently grafted titanium alloy with chitosan through TriEthoxySilylPropylSuccinic Anhydride process to prevent post-surgical infection [ 63 ]. That study revealed that CS positively charged quaternary ammonium moieties exerted strong electrostatic interactions on the negatively charged bacterial cell surface, leading to microbial membrane disruption and bacterial death [ 56 , 63 , 64 ].…”

Section: Bioengineering Materials As Therapeutic Approachesmentioning

confidence: 99%

“…These solutions cause changes in the physicochemical properties of the biomaterial’s surfaces, interfering with bacterial adherence and host adhesins adsorption [ 49 , 66 , 67 , 74 , 75 , 76 , 77 , 78 , 79 ]. An et al, using a rabbit model, showed that albumin-coated implants presented a lower infection rate than non-coated implants [ 64 , 74 , 80 , 81 , 82 ]. This inhibition can be explained through binding to the bacterial receptors or by changing the substratum surface to a more hydrophilic behavior [ 74 , 75 ].…”

Section: Bioengineering Materials As Therapeutic Approachesmentioning

confidence: 99%

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Bioengineering Approaches to Fight against Orthopedic Biomaterials Related-Infections

Barros

Monteiro

Ferraz

2022

IJMS

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One of the most serious complications following the implantation of orthopedic biomaterials is the development of infection. Orthopedic implant-related infections do not only entail clinical problems and patient suffering, but also cause a burden on healthcare care systems. Additionally, the ageing of the world population, in particular in developed countries, has led to an increase in the population above 60 years. This is a significantly vulnerable population segment insofar as biomaterials use is concerned. Implanted materials are highly susceptible to bacterial and fungal colonization and the consequent infection. These microorganisms are often opportunistic, taking advantage of the weakening of the body defenses at the implant surface–tissue interface to attach to tissues or implant surfaces, instigating biofilm formation and subsequent development of infection. The establishment of biofilm leads to tissue destruction, systemic dissemination of the pathogen, and dysfunction of the implant/bone joint, leading to implant failure. Moreover, the contaminated implant can be a reservoir for infection of the surrounding tissue where microorganisms are protected. Therefore, the biofilm increases the pathogenesis of infection since that structure offers protection against host defenses and antimicrobial therapies. Additionally, the rapid emergence of bacterial strains resistant to antibiotics prompted the development of new alternative approaches to prevent and control implant-related infections. Several concepts and approaches have been developed to obtain biomaterials endowed with anti-infective properties. In this review, several anti-infective strategies based on biomaterial engineering are described and discussed in terms of design and fabrication, mechanisms of action, benefits, and drawbacks for preventing and treating orthopaedic biomaterials-related infections.

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Section: Bioengineering Materials As Therapeutic Approachesmentioning

confidence: 99%

Section: Bioengineering Materials As Therapeutic Approachesmentioning

confidence: 99%

Bioengineering Approaches to Fight against Orthopedic Biomaterials Related-Infections

Barros

Monteiro

Ferraz

2022

IJMS

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“…Recently, natural and synthetic nanostructures have attracted more and more attention from researchers since they mediate the mechanical rupture of bacterial cells. − Titanium dioxide (TiO 2 ) nanomaterial is generally used in the surface modification of medical Ti and its alloys due to the excellent chemical stability . Moreover, the biocompatibility of TiO 2 nanomaterial has also been proved by many studies. − On the other hand, multiscale surface treatments have been implemented to acquire multiscale functional hybrid-modified coating to adjust the roughness, wettability, bioactivity, and biological performance of a Ti implant, including macroscale treatments (e.g., 3D printing and laser surface texturing), microscale treatments (e.g., grit-blasting and acid-etching), and nanoscale treatments (e.g., plasma-spraying and anodization). , In recent years, ion implantation technology is a new type of surface modification technology that can effectively perform surface modification without affecting the overall performance of the material .…”

Section: Introductionmentioning

confidence: 99%

Implanting a Copper Ion into a TiO₂ Nanorod Array for the Investigation on the Synergistic Antibacterial Mechanism between Mechanical Cracking and Chemical Damage

Chen

Zhang

Yang

et al. 2022

ACS Biomater. Sci. Eng.

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Titanium (Ti) and its alloys are extensively applied in dental and orthopedic implants due to their characteristics of good mechanical property and corrosion resistance. However, Ti and its alloys suffer from the absence of certain biological activity and antibacterial ability. Herein, we synthesized a titanium dioxide (TiO 2 ) nanorod array on the surface of a Ti plate, and the obtained TiO 2 nanorod array was further modified by Cu ions through ion implantation technology in an attempt to endow medical Ti with an antibacterial ability and maintain a normal biological function synchronously. The antibacterial ability of the TiO 2 nanorod array with the incorporation of Cu ions was vastly improved compared with those of the unmodified TiO 2 nanorod array and pure Ti. In particular, owing to the synergy between the chemical damage of the released Cu 2+ to the cell and the mechanical cracking of the TiO 2 nanorod array, the antibacterial rate of the TiO 2 nanorod array modified by Cu ions against Escherichia coli or Staphylococcus aureus could reach 99%. In addition, no cytotoxicity was detected in such prepared coating during the CCK-8 assay. Moreover, the corrosion resistance of the sample was significantly better than that of pure Ti. Overall, we demonstrated that the application of ion implantation technology could open up a promising pathway to design and develop further antibacterial material for the biomedical domain.

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“…Topographical features on a micro-or nanoscale could impact bacterial attachment via hydrodynamic interactions or by physicochemical forces and chemical gradients, respectively [17]. Various hierarchical patterns with pre-defined dimensions on both a microand nanoscale have been explored as ways to develop antimicrobial surfaces [18][19][20][21]. Surface features with different geometries such as pillars, single pits or channels could be realized via lithographic methods, etching or laser surface processing [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

“…Various hierarchical patterns with pre-defined dimensions on both a microand nanoscale have been explored as ways to develop antimicrobial surfaces [18][19][20][21]. Surface features with different geometries such as pillars, single pits or channels could be realized via lithographic methods, etching or laser surface processing [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Ultra-Short Laser Surface Properties Optimization of Biocompatibility Characteristics of 3D Poly-ε-Caprolactone and Hydroxyapatite Composite Scaffolds

et al. 2021

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The use of laser processing for the creation of diverse morphological patterns onto the surface of polymer scaffolds represents a method for overcoming bacterial biofilm formation and inducing enhanced cellular dynamics. We have investigated the influence of ultra-short laser parameters on 3D-printed poly-ε-caprolactone (PCL) and poly-ε-caprolactone/hydroxyapatite (PCL/HA) scaffolds with the aim of creating submicron geometrical features to improve the matrix biocompatibility properties. Specifically, the present research was focused on monitoring the effect of the laser fluence (F) and the number of applied pulses (N) on the morphological, chemical and mechanical properties of the scaffolds. SEM analysis revealed that the femtosecond laser treatment of the scaffolds led to the formation of two distinct surface geometrical patterns, microchannels and single microprotrusions, without triggering collateral damage to the surrounding zones. We found that the microchannel structures favor the hydrophilicity properties. As demonstrated by the computer tomography results, surface roughness of the modified zones increases compared to the non-modified surface , without influencing the mechanical stability of the 3D matrices. The X-ray diffraction analysis confirmed that the laser structuring of the matrices did not lead to a change in the semi-crystalline phase of the PCL. The combinations of two types of geometrical designs—wood pile and snowflake—with laser-induced morphologies in the form of channels and columns are considered for optimizing the conditions for establishing an ideal scaffold, namely, precise dimensional form, mechanical stability, improved cytocompatibility and antibacterial behavior.

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Impact of surface topography on the bacterial attachment to micro- and nano-patterned polymer films

Cited by 21 publications

References 49 publications

Bioengineering Approaches to Fight against Orthopedic Biomaterials Related-Infections

Bioengineering Approaches to Fight against Orthopedic Biomaterials Related-Infections

Implanting a Copper Ion into a TiO₂ Nanorod Array for the Investigation on the Synergistic Antibacterial Mechanism between Mechanical Cracking and Chemical Damage

Ultra-Short Laser Surface Properties Optimization of Biocompatibility Characteristics of 3D Poly-ε-Caprolactone and Hydroxyapatite Composite Scaffolds

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Impact of surface topography on the bacterial attachment to micro- and nano-patterned polymer films

Cited by 21 publications

References 49 publications

Bioengineering Approaches to Fight against Orthopedic Biomaterials Related-Infections

Bioengineering Approaches to Fight against Orthopedic Biomaterials Related-Infections

Implanting a Copper Ion into a TiO2 Nanorod Array for the Investigation on the Synergistic Antibacterial Mechanism between Mechanical Cracking and Chemical Damage

Ultra-Short Laser Surface Properties Optimization of Biocompatibility Characteristics of 3D Poly-ε-Caprolactone and Hydroxyapatite Composite Scaffolds

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Product

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Implanting a Copper Ion into a TiO₂ Nanorod Array for the Investigation on the Synergistic Antibacterial Mechanism between Mechanical Cracking and Chemical Damage