To improve the antibacterial effect
of a poly(ε-caprolactone)/gelatin
(PCL/Gt) composite, Cu nanoparticles (Cu NPs) were synthesized as
an antibacterial agent, and a Cu NPs/PCL/Gt fiber membrane was thus
fabricated via green electrospinning. The results
showed that the Cu NPs/PCL/Gt fiber membrane with a uniform and complete
structure exhibited high porosity and water absorption, favorable
hydrophilicity, good mechanical and thermal properties, and satisfactory
antibacterial activity. The easy preparation and good comprehensive
property implied the great potential application of the Cu NPs/PCL/Gt
fiber membrane in various fields (e.g., wound dressing
and antibacterial clothing). In addition, the synthesis in this work
would offer a promising approach for the preparation of a metal nanoparticle/polymer
fiber material with good antibacterial property.
Titanium (Ti) and its alloys are extensively applied in dental and orthopedic implants due to their characteristics of good mechanical property and corrosion resistance. However, Ti and its alloys suffer from the absence of certain biological activity and antibacterial ability. Herein, we synthesized a titanium dioxide (TiO 2 ) nanorod array on the surface of a Ti plate, and the obtained TiO 2 nanorod array was further modified by Cu ions through ion implantation technology in an attempt to endow medical Ti with an antibacterial ability and maintain a normal biological function synchronously. The antibacterial ability of the TiO 2 nanorod array with the incorporation of Cu ions was vastly improved compared with those of the unmodified TiO 2 nanorod array and pure Ti. In particular, owing to the synergy between the chemical damage of the released Cu 2+ to the cell and the mechanical cracking of the TiO 2 nanorod array, the antibacterial rate of the TiO 2 nanorod array modified by Cu ions against Escherichia coli or Staphylococcus aureus could reach 99%. In addition, no cytotoxicity was detected in such prepared coating during the CCK-8 assay. Moreover, the corrosion resistance of the sample was significantly better than that of pure Ti. Overall, we demonstrated that the application of ion implantation technology could open up a promising pathway to design and develop further antibacterial material for the biomedical domain.
Titanium
(Ti) is an excellent medical metal material, but the absence
of good antibacterial property restricts its widespread application.
To overcome this, we thus conducted a series of modifications for
Ti. First, a titanium dioxide (TiO2) nanorod array was
generated on the Ti surface by hydrothermal treatment (TiO2/Ti). With the polymer-mediated self-assembly method, a continuous
copper (Cu) shell structure on the surface of the nanorod was then
generated to form a TiO2@Cu core–shell nanorod array
as coating for Ti (TiO2@Cu/Ti). Using pure Ti as the control
group, the antibacterial properties of TiO2/Ti and TiO2@Cu/Ti were appraised. The results manifested that the mechanical
and chemical dual function of the released Cu2+ and TiO2 nanorod array could effectively kill bacteria on the surface
of Ti. Besides, the obtained coating exhibited no cytotoxicity and
favorable biocompatibility. In this work, we found an antibacterial
strategy based on multiple sterilization pathways, which made Ti have
good antibacterial property and further improved its biocompatibility.
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