Impact of Sonoclot hemostasis analysis after cardiopulmonary bypass on postoperative hemorrhage in cardiac surgery

Yamada, Tatsuya; Katori, Nobuyuki; Tanaka, Kenichi A.; Takeda, Junzo

doi:10.1007/s00540-006-0477-7

Cited by 28 publications

(28 citation statements)

References 21 publications

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“…A slightly different principle is embodied in the Sonoclot instruments, in that the viscoelastic probe vibrates vertically, 118 and the shape of the trace is somewhat different, producing a 'signature' with various peaks 106,[125][126][127] (Fig. 5).…”

Section: Thromboelastography Thromboelastometry and Sonoclot Instrummentioning

confidence: 99%

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

Kell

Pretorius

2014

Integrative Biology

127

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Although the two phenomena are usually studied separately, we summarise a considerable body of literature to the effect that a great many diseases involve (or are accompanied by) both an increased tendency for blood to clot (hypercoagulability) and the resistance of the clots so formed (hypofibrinolysis) to the typical, 'healthy' or physiological lysis. We concentrate here on the terminal stages of fibrin formation from fibrinogen, as catalysed by thrombin. Hypercoagulability goes hand in hand with inflammation, and is strongly influenced by the fibrinogen concentration (and vice versa); this can be mediated via interleukin-6. Poorly liganded iron is a significant feature of inflammatory diseases, and hypofibrinolysis may change as a result of changes in the structure and morphology of the clot, which may be mimicked in vitro, and may be caused in vivo, by the presence of unliganded iron interacting with fibrin(ogen) during clot formation. Many of these phenomena are probably caused by electrostatic changes in the iron-fibrinogen system, though hydroxyl radical (OH ) formation can also contribute under both acute and (more especially) chronic conditions. Many substances are known to affect the nature of fibrin polymerised from fibrinogen, such that this might be seen as a kind of bellwether for human or plasma health. Overall, our analysis demonstrates the commonalities underpinning a variety of pathologies as seen in both hypercoagulability and hypofibrinolysis, and offers opportunities for both diagnostics and therapies.

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Section: Thromboelastography Thromboelastometry and Sonoclot Instrummentioning

confidence: 99%

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

Kell

Pretorius

2014

Integrative Biology

127

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“…In contrast, in critically ill humans receiving enoxaparin TEG R‐times differed significantly between patients that experienced a deep vein thrombosis and those that did not while anti‐factor Xa activity was similar between the 2 groups suggesting that TEG rather than anti‐factor Xa activity might be the more appropriate monitoring technique . There is less information about the utility of the Sonoclot analyzer; however, Sonoclot ACT has a similar reliability and accuracy when compared to established measures of coagulation and Sonoclot analysis has utility in the prediction of hemorrhage following cardiopulmonary bypass surgery …”

Section: Discussionmentioning

confidence: 99%

“…Although this assay has been used to measure anti‐factor Xa activity in horses, it is relatively expensive and not available in most veterinary hospitals. Thromboelastography (TEG) and Sonoclot are point‐of‐care viscoelastic coagulation tests that provide real time measures of the rate of clot formation and clot strength and have been evaluated for monitoring anticoagulant therapy in select human hospital populations . TEG and Sonoclot are becoming more widely available in veterinary medicine.…”

Section: Introductionmentioning

confidence: 99%

Use of viscoelastic coagulation testing to monitor low molecular weight heparin administration to healthy horses

Tennent-Brown

Epstein

Whelchel

et al. 2013

J Vet Emergen Crit Care

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“…Fondaparinux is a new anticoagulant that interacts with antithrombin III and activated coagulation factor X resulting in an inhibition of the coagulation system. It has been concluded that the Sonoclot parameter clot rate could be of clinical value to individualize the fondaparinux dosage, especially the higher, therapeutic, dosages [8].…”

Section: Introductionmentioning

confidence: 99%

Assessment of heparin anticoagulation by Sonoclot Analyzer in arterial reconstruction surgery

Lee

Al-Waili

Butler³

et al. 2011

THC

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Since heparin has been in use as an anticoagulant during vascular surgery and medical problems such as DVT or pulmonary embolism, there has been no consensus as to the best method of monitoring its effect on anticoagulation. In this study we used Sonoclot Analyzer to detect hemostasis changes resulting from heparin administration. The study involved 16 randomly selected male patients undergoing peripheral reconstructive surgery. Blood samples were drawn and analyzed in the operating room on the Sonoclot Coagulation and Platelet Function Analyzer. Results showed that patients respond to heparin differently. The Sonoclot monitors the hemodynamics of blood using four variables: SonACT (activated clotting time) time, rate, peak, and contraction rate. Heparin has three effective on the Sonoclot Signature; prolonged ACT result, lower clot rate, and reduction in clot retraction. The SonACT time is the time for first fibrin to form. Prolong this time indicates the presence of anticoagulation. The Sonoclot Analyzer results confirm that it is a reliable and sensitive device for monitoring heparinization levels.

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Impact of Sonoclot hemostasis analysis after cardiopulmonary bypass on postoperative hemorrhage in cardiac surgery

Abstract: Our results suggest that abnormal postoperative hemorrhage can be predicted by Sonoclot analysis with a new glass bead-activated heparinase test performed after CPB.

Cited by 28 publications

References 21 publications

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

Use of viscoelastic coagulation testing to monitor low molecular weight heparin administration to healthy horses

Assessment of heparin anticoagulation by Sonoclot Analyzer in arterial reconstruction surgery

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