Impact of solvent on Co/SiO2 activity and selectivity for the synthesis of n-butylamine from butyronitrile hydrogenation

Carbocatalysis in Liquid‐Phase Reactions

“…However, the solvent can also hinder the adsorption of reactants at certain sites, but enhance the adsorption of reactants at other sites. As a result, the product selectivity can be tuned by using a suitable solvent, as demonstrated in metal‐mediated reactions …”

Catalyst-Dependent Selective Hydrogenation of Nitriles: Selective Synthesis of Tertiary and Secondary Amines

“…Recently, several hydrogenation methods for the selective preparation of primary amines from nitriles by the use of ruthenium, iron, cobalt, palladium, and palladium–nickel alloy catalysts have been developed. In contrast, a relatively limited number of methods have been reported for the selective hydrogenation of nitriles toward secondary or tertiary amines. − Berk et al reported that a rhenium-catalyzed hydrogenation of aromatic nitriles and cyclohexanecarbonitrile at 140 °C under 75 bar hydrogen pressure selectively afforded the corresponding secondary amines, where the corresponding tertiary amine was majorly formed only from benzyl cyanide with 85% selectivity . Liu et al developed a synthetic method for the preparation of secondary amines by cobalt-catalyzed transfer hydrogenation of benzonitriles using ammonia borane as a hydrogen donor in hexafluoro-2-propanol; however, only two examples for aliphatic nitriles including benzyl cyanide as the substrates were reported, and low to moderate yields were obtained .…”

Carbokatalyse in Flüssigphasenreaktionen

“…Sie kann auch die Adsorption des Reaktanten an eine bestimmte Art aktiver Zentren blockieren und somit die Wechselwirkung mit anderen Arten aktiver Zentren begünstigen. Auf diesem Wege könnte die Wahl des Lösungsmittels die Produktselektivität beeinflussen, was für Metallkatalysatoren bereits berichtet wurde …”