Impact of sleep on female and male reproductive functions: a systematic review

Caetano, Gabriela; Bozinovic, Inès; Dupont, Charlotte; Léger, Damien; Lévy, Rachel; Sermondade, Nathalie

doi:10.1016/j.fertnstert.2020.08.1429

Cited by 49 publications

(45 citation statements)

References 63 publications

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“…This supports the hypothesis that excess oxidative stress and compromised immunity due to sleep problems can affect fertility [168,171]. Short sleep is also significantly associated with chronic diseases, such as obesity, type 2 diabetes, and cardiovascular diseases which can also influence fertility [170]. Interestingly, sleep alterations have been related also to assisted reproduction techniques outcomes.…”

Section: Sleepsupporting

confidence: 75%

“…Sleep affects also various aspects of female fertility and pregnancy. Women who had a mean sleep duration less than five hours experienced an increased risk of menstrual cycle irregularities, compared to those who had more than eight hours of sleep every day [170]. Another study reported that women who had less than six hours of sleep every day and experienced trouble sleeping had a relatively lesser fecundability rate compared to women who slept 8 h per night and had no trouble sleeping (Figure 3) [164].…”

Section: Sleepmentioning

confidence: 99%

“…Shift work causes circadian dysrhythmia which interferes with fertility by altering the secretion of reproductive hormones, increasing insulin resistance and inflammation. Studies on murine models have reported that circadian rhythm disorders have an impact on fertility, independent of the hypothalamic-pituitary axis [170]. Several mechanisms may be involved in this process.…”

Section: Sleepmentioning

confidence: 99%

“…Lifestyle-related factors able to influence human reproduction. Physical activity (PA), stress and sleep have been related to different effects on both fertility and in vitro fertilization (IVF) procedure outcomes[145][146][147][148]151,[156][157][158][159][160][161][164][165][166][167]170,173].…”

mentioning

confidence: 99%

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Unraveling the Balance between Genes, Microbes, Lifestyle and the Environment to Improve Healthy Reproduction

D’Argenio

Dittfeld²,

Lazzeri³

et al. 2021

Genes

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Humans’ health is the result of a complex and balanced interplay between genetic factors, environmental stimuli, lifestyle habits, and the microbiota composition. The knowledge about their single contributions, as well as the complex network linking each to the others, is pivotal to understand the mechanisms underlying the onset of many diseases and can provide key information for their prevention, diagnosis and therapy. This applies also to reproduction. Reproduction, involving almost 10% of our genetic code, is one of the most critical human’s functions and is a key element to assess the well-being of a population. The last decades revealed a progressive decline of reproductive outcomes worldwide. As a consequence, there is a growing interest in unveiling the role of the different factors involved in human reproduction and great efforts have been carried out to improve its outcomes. As for many other diseases, it is now clear that the interplay between the underlying genetics, our commensal microbiome, the lifestyle habits and the environment we live in can either exacerbate the outcome or mitigate the adverse effects. Here, we aim to analyze how each of these factors contribute to reproduction highlighting their individual contribution and providing supporting evidence of how to modify their impact and overall contribution to a healthy reproductive status.

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Section: Sleepsupporting

confidence: 75%

Section: Sleepmentioning

confidence: 99%

Section: Sleepmentioning

confidence: 99%

mentioning

confidence: 99%

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Unraveling the Balance between Genes, Microbes, Lifestyle and the Environment to Improve Healthy Reproduction

D’Argenio

Dittfeld²,

Lazzeri³

et al. 2021

Genes

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“…Characterizing sleep is increasingly complex, but the essential feature is that sleep follows cycles that parallel the reproductive cycle. Healthy sleep consists of repetitive cycles of 90-120 minutes containing four to six phases of alternating rapid eye movement and non-rapid eye movement sleep (1,3). Circadian rhythms control the sleep-wake cycle (1) as well as the cycling of reproductive hormones throughout the day (1,3).…”

mentioning

confidence: 99%

In the arms of Morpheus: meta-analysis of sleep and fertility

Auger

Healy‐Profitós

Wei

2021

Fertility and Sterility

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Sleep and health are closely linked (1, 2). Sleep quality and quantity impact how well the brain functions and influence the metabolic, immunologic, hormonal, and cardiovascular systems (1). Poor sleep is associated with an increased risk of type 2 diabetes, obesity, cardiovascular disease, cancer, and mortality (1-3). Poor sleep also has a negative influence on cognition, memory, mood, and stress tolerance (1-3). Despite the obvious implications of sleep for multiple body systems (1-3), its involvement in reproductive function is less understood (3).Sleep medicine is a relatively new field and has only been around for 50 years (2). Once scientists discovered that the brain produced electric signals, it became possible to study

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Childbearing, Infertility, and Career Trajectories Among Women in Medicine

et al. 2023

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ImportanceAlthough women are increasingly represented within medicine, gender disparities persist in time to promotion, achievement of academic rank, and appointment to leadership positions, with no narrowing of this gap over time. Career-specific fertility and family building challenges among women physicians may contribute to ongoing disparities and academic attrition.ObjectiveTo evaluate delayed childbearing and infertility among women in medicine and investigate the extent to which women physicians may alter career trajectories to accommodate family building and parenthood.Design, Setting, and ParticipantsThis survey study was conducted among women physicians, with surveys distributed through medical society electronic mailing lists (listserves) and social media from March to August 2022.Main Outcomes and MeasuresBaseline demographic information and fertility knowledge were assessed. Descriptive data on delayed childbearing, infertility, use of assisted reproductive technology, and career alterations to accommodate parenthood were collected. Factors associated with timing of pregnancy and family building regret were assessed using Likert-type scales. Group differences in fertility knowledge, delayed childbearing, infertility, and family building regret were evaluated using χ2 analyses.ResultsA total of 1056 cisgender women (mean [SD] age, 38.3 [7.7] years) were surveyed across level of training (714 attending physicians [67.6%] and 283 residents or fellows [26.8%]), specialty (408 surgical [38.6%] and 638 nonsurgical [60.4%] specialties), and practice setting (323 academic [45.2%], 263 private [24.9%], and 222 community [21.0%] settings). Among respondents, 1036 individuals [98.1%] resided in the US. Overall, 910 respondents (86.2%) were married or partnered and 690 respondents (65.3%) had children. While 824 physicians (78.0%) correctly identified the age of precipitous fertility decline, 798 individuals (75.6%) reported delaying family building and 389 individuals (36.8%) had experienced infertility. Concerning measures taken to accommodate childbearing or parenthood, 199 women (28.8%) said they had taken extended leave, 171 women (24.8%) said they had chosen a different specialty, 325 women (47.1%) said they had reduced their work hours, 171women (24.8%) said they had changed their practice setting, and 326 women (47.2%) said they had passed up opportunities for career advancement among those with children. Additionally, 30 women with children (4.3%) had left medicine entirely.Conclusions and RelevanceIn this survey study, women physicians reported that career-related pressures influenced the timing of childbearing and led to marked alterations to career trajectories to accommodate family building and parenthood. These findings suggest that fertility and family building concerns among women in medicine may contribute to ongoing gender disparities and attrition and represent a potentially critical area for policy reform and future change.

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Impact of sleep on female and male reproductive functions: a systematic review

Abstract: Objective: To evaluate the association of sleep parameters on female and male reproductive functions.Design: Systematic review.Setting: Not applicable. Patient(s):Both female and male individuals, either healthy or infertile.

Cited by 49 publications

References 63 publications

Unraveling the Balance between Genes, Microbes, Lifestyle and the Environment to Improve Healthy Reproduction

Unraveling the Balance between Genes, Microbes, Lifestyle and the Environment to Improve Healthy Reproduction

In the arms of Morpheus: meta-analysis of sleep and fertility

Childbearing, Infertility, and Career Trajectories Among Women in Medicine

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