Impact of single nucleotide polymorphisms in the <i>OGG1</i> and <i>XRCC1</i> genes on modulation of DNA damage in pesticide-exposed agricultural workers in Punjab, North-West India

Kaur, Karashdeep; Kaur, Rupinder

doi:10.1080/1354750x.2020.1794040

Cited by 5 publications

(1 citation statement)

References 45 publications

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“…These ndings were consistent with the results observed in the control group. Conversely, a notable correlation was discovered between DNA damage and pesticide exposure among agricultural workers [37]. These discrepancies could potentially be attributed to relatively small sample sizes and variations in genetic backgrounds among the studies.…”

Section: Discussionmentioning

confidence: 92%

Investigation of the association between polymorphisms in DNA repair enzymes and STEMI

Güven

Çitak

Malikova

et al. 2023

Preprint

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Background: STEMI (ST-elevation myocardial infarction) is one of the most severe forms of coronary artery disease, known to significantly contribute to DNA damage. There are very few publications in this field in the literature. In our study, we examined the association between four polymorphisms in repair enzymes (LIG4 Thr9Ile, XRCC6 promoter C-57G, XPA -4A/G, OGG1 Ser326Cys) involved in three distinct DNA repair mechanisms (NHEJ (non-homologous end joining), NER (nucleotide excision repair), and BER (base excision repair), and their impact on the risk of STEMI. Methods & Results: This study involved 185 patients diagnosed with STEMI and included 100 healthy controls. The genotyping of SNPs was conducted through the PCR-RFLP (Polymerase chain reaction-restriction fragment length polymorphism) method for the following variants: XRCC6 (rs2267437), XPA (rs1800975), LIG4 ( rs1805388), and OGG1 (rs1052133). No significant differences were observed in the genotype distributions of the XRCC6 and OGG1 variations between the control and patient groups. On the other hand, our findings indicate that individuals carrying the mutant G allele for XPA polymorphism and the mutant Tallele for LIG4 polymorphism are susceptible to STEMI. Conclusions: Our findings demonstrate the significance of NHEJ and NER DNA repair processes in the pathogenesis of STEMI, as evidenced by the observed relationship between LIG4 and XPA polymorphisms.

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Section: Discussionmentioning

confidence: 92%

Investigation of the association between polymorphisms in DNA repair enzymes and STEMI

Güven

Çitak

Malikova

et al. 2023

Preprint

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The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity

et al. 2023

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In Brazil, high levels of agricultural activity are re ected in the consumption of enormous amounts of pesticide. The production of grain in Brazil has been estimated to reach 289.8 million tons in the 2022 harvest, an increase of 14.7% in comparison with 2021, with an even greater increase being predicted for Goiás, one of the country's principal grain producing states. These advances are likely associated with a progressive increase in the occupational exposure of rural workers to pesticides. The PON1 gene activates the enzymes involved in phase I of liver detoxi cation. The rs662 variant of this gene is known to modify the activity of the PON1 enzyme, which can increase the susceptibility of an individual to pesticides, leading to more severe symptoms or the development of diseases. The present study describes the frequencies of the rs25487 (of the XRCC gene) and rs662 variants and their haplotypes in a sample population from Goiás, Brazil, and compares the frequencies with other populations from around the world to verify the variation in the distribution of these Single Nucleotide Polymorphisms (SNPs). The study analyzed samples taken from 494 unrelated individuals resident in the state of Goiás. The A allele of the rs25487 variant had a frequency of 26% in the Goiás study population, and the modi ed rs662 G allele had a frequency of 42.8%. Four haplotypes were recorded for the rs25487 (G > A) and rs662 (A > G) markers, with a frequency of 11.9% being recorded for the A/G haplotype (both modi ed alleles), 30.8% for the G/G haplotype, 14.3% for the A/A haplotype, and 42.8% for the G/A haplotype (both wild-type alleles). In conclusion, we demonstrated the distribution of important SNPs associated with pesticide exposure in an area that presents a high level of agricultural activity.

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Modulation of DNA damage by XPF, XPG and ERCC1 gene polymorphisms in pesticide-exposed agricultural workers of Punjab, North-West India

Kaur

2021

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Impact of single nucleotide polymorphisms in the OGG1 and XRCC1 genes on modulation of DNA damage in pesticide-exposed agricultural workers in Punjab, North-West India

Cited by 5 publications

References 45 publications

Investigation of the association between polymorphisms in DNA repair enzymes and STEMI

Investigation of the association between polymorphisms in DNA repair enzymes and STEMI

The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity

Modulation of DNA damage by XPF, XPG and ERCC1 gene polymorphisms in pesticide-exposed agricultural workers of Punjab, North-West India

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