Impact of Sickle Cell Disease in Renal Arteries Blood Flow Indices Using Ultrasonography

Eltahir, Mohamed Abdalla

doi:10.11648/j.ijmi.20170502.11

Cited by 3 publications

References 12 publications

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Pattern of Renal Blood Flow and Renovascular Parameters in Adult Patients With Sickle Cell Disease

Asbeutah

Adekile

Almajran

et al. 2019

J of Ultrasound Medicine

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Objectives To evaluate renal blood flow patterns and renovascular parameters in adult patients with sickle cell disease (SCD) without laboratory evidence of renal impairment. Methods Sixty‐five steady‐state adult patients with SCD (50 hemoglobin SS [HbSS], 12 HbSβ0, and 3 HbSD) and 30 age‐ and sex‐matched healthy controls were studied. The kidney length, echo pattern, peak systolic velocity (PSV), end‐diastolic velocity, renal‐to‐aortic ratio, resistive index (RI), acceleration time (AT), and renal vein velocity were acquired, recorded, and analyzed with a 1–5‐MHz curvilinear transducer through the abdomen. Results The mean age ± SD of the patients with SCD was 32.89 ± 13.89 years. The highest means for the ultrasound‐measured renal length and cortical thickness in the SCD and control groups were 11.78 ± 1.30 and 11.27 ± 0.77 cm and 1.86 ± 0.41 and 1.78 ± 0.28 cm, respectively. The figures were significantly higher in the SCD group than the control group (P < .05). Fifty‐nine (90.8%) patients had a mild diffuse increase in cortical echogenicity with preserved renal cortical thickness. The highest mean extrarenal PSVs in the SCD and control groups were 138.46 ± 56.32 and 101.75 ± 31.48 cm/s (P < .05). However, the highest intrarenal RI and AT in SCD and control groups were 0.69 ± 0.07 and 0.06 ± 0.02 seconds and 0.63 ± 0.05 and 0.04 ± 0.01 seconds (P < .05). There was no significant correlation between the RI, AT, and PSV among the patients with SCD (P > .05). Conclusions Increased renal length and cortical echogenicity with elevated PSV, RI, and AT values can serve as early ultrasound changes in adult patients with SCD without renal impairment.

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Pattern of Renal Blood Flow and Renovascular Parameters in Adult Patients With Sickle Cell Disease

Asbeutah

Adekile

Almajran

et al. 2019

J of Ultrasound Medicine

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Renal Doppler sonography as a non-invasive technique for early detection of reno-vascular changes in sickle cell disease in children

Eltagui,

Seif Eldein,

Elhady

et al. 2023

Egypt Pediatric Association Gaz

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Objective Early identification of sickle renovascular changes via renal Doppler sonography among sickle cell disease patients to help in early diagnosis and interventions to prevent progression to end-stage renal disease. Methods Forty-five SCD children were included along with 45 healthy control children. Renal Doppler sonography (PI and RI) was performed on all subjects. Laboratory investigations were done: Hb electrophoresis, complete blood picture with blood indices, reticulocyte count, liver enzymes (ALT and AST), HCV serology, serum ferritin, and lactate dehydrogenase (LDH). Urine analysis and albumin/creatinine ratio in urine were done for all patients as well. Results The study group consisted of 45 SCD patients, 27 (60%) males with a mean age of 12 years (± 3 years). By performing renal Doppler sonography, it was found that all study groups had significantly higher Doppler indices (resistivity index and pulsatility index) compared to the control group. Results of renal Doppler sonography revealed that the main renal pulsatility index was positively correlated with the main renal resistance index (r = 0.454, p = 0.002). Conclusion Doppler indices (resistance index and pulsatility index) were of value to assess reno-vascular changes in SCD, Thus, renal Doppler indices could be an early technique in the assessment of sickle renovascular changes, so treatment can be started at an early stage before progressive affection of renal function.

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Renal Doppler Sonography As A Non-Invasive Technique For Early Detection Of Sickle Nephropathy In Children

Tagui

Seif

Hady

et al. 2023

Preprint

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Objective: Early identification of sickle nephropathy via renal doppler sonography among sickle cell disease patients so as to help in early diagnosis and interventions to prevent progression to end-stage renal disease. Methods: 45 SCD children were included along with 45 healthy control children. Renal doppler sonography (PI and RI) was performed to all subjects. Doppler indices (Resistance Index and pulsatility index) were of value to assess reno-vascular changes in SCD. Laboratory investigations were done: Hb electrophoresis, complete blood picture with blood indices, reticulocytic count, liver enzymes (ALT and AST), HCV serology, serum ferritin and lactate dehydrogenese (LDH). Results: The study group consisted of 45 SCD patients, 27 (60%) males with mean age 12 years (± 3 years). By performing renal doppler sonography, it was found that all study group had significantly higher doppler indices (Resistivity index and pulsatility index) compared to the control group. Results of renal doppler sonography revealed, Main renal pulsatility index was positively correlated with main renal resistance index (r=0.454, p=0.002). Conclusion: Roc curve showed that Main Renal Artery Pulsatility index and resistance index index could act as a predictor for sickle cell nephropathy with high sensitivity values. Otherwise, renal doppler indices didn’t show statistically significant correlation with the other studied variables.

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Impact of Sickle Cell Disease in Renal Arteries Blood Flow Indices Using Ultrasonography

Cited by 3 publications

References 12 publications

Pattern of Renal Blood Flow and Renovascular Parameters in Adult Patients With Sickle Cell Disease

Pattern of Renal Blood Flow and Renovascular Parameters in Adult Patients With Sickle Cell Disease

Renal Doppler sonography as a non-invasive technique for early detection of reno-vascular changes in sickle cell disease in children

Renal Doppler Sonography As A Non-Invasive Technique For Early Detection Of Sickle Nephropathy In Children

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