Impact of serum vitamin D on the response and prognosis in breast cancer patients treated with neoadjuvant chemotherapy

Tokunaga, Eriko; Masuda, Takanobu; Ijichi, Hideki; Tajiri, Wakako; Koga, Chinami; Koi, Yumiko; Nakamura, Yoshiaki; Ohno, Shinji; Taguchi, Kenichi; Okamoto, Masahiro

doi:10.1007/s12282-021-01292-3

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Twenty‐three publications 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 on serum 25(OH)D were reviewed (Table S24 ). Linear dose‐response meta‐analyses were conducted for all‐cause and breast cancer‐specific mortality.…”

Section: Resultsmentioning

confidence: 99%

Postdiagnosis dietary factors, supplement use and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

Becerra‐Tomás

Balducci

Abar

et al. 2022

Intl Journal of Cancer

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Little is known about how diet might influence breast cancer prognosis. The current systematic reviews and meta-analyses summarise the evidence on postdiagnosis dietary factors and breast cancer outcomes from randomised controlled trials and longitudinal observational studies. PubMed and Embase were searched through 31st October 2021. Random-effects linear dose-response meta-analysis was conducted when at least three studies with sufficient information were available. The quality of the evidence was evaluated by an independent Expert Panel. We identified 108 publications. No meta-analysis was conducted for dietary patterns, vegetables, wholegrains, fish, meat, and supplements due to few studies, often with insufficient data. Meta-analysis was only possible for all-cause mortality with dairy, isoflavone, carbohydrate, dietary fibre, alcohol intake and serum 25-hydroxyvitamin D (25(OH)D), and for breast cancer-specific mortality with fruit, dairy, carbohydrate, protein, dietary fat, fibre, alcohol intake and serum 25(OH)D. The results, with few exceptions, were generally null. There was limited-suggestive evidence that predefined dietary patterns may reduce the risk of all-cause and other causes of death; that isoflavone intake reduces the risk of all-cause mortality (relative risk (RR) per 2 mg/day: 0.96, 95% confidence interval (CI): 0.92-1.02), breast cancer-specific mortality (RR for high

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Section: Resultsmentioning

confidence: 99%

Postdiagnosis dietary factors, supplement use and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

Becerra‐Tomás

Balducci

Abar

et al. 2022

Intl Journal of Cancer

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“…Previously published results were inconsistent, but many authors observed an inverse association between VD levels before treatment and mortality in BC patients [ 45 , 46 ]; others did not confirm this relationship [ 47 ]. Among others, Tokunaga et al showed that levels of VD over 23.6 ng/mL diminished the risk of BC-related mortality in newly diagnosed patients [ 9 ]. Vrieling et al in a prospective study of BC patients found that a lower level of 25(OH)D assessed via enzyme immunoassay methodology was related to a higher risk of death [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…Low levels of VD increase the risk of BC development [ 8 ], and may affect the efficacy of treatment and patients’ prognosis [ 7 , 9 ]. The metabolic effects of VD are mediated not only by its active form but also metabolites [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Its Metabolites Status before and during Chemotherapy in Caucasian Breast Cancer Patients

Kimsa-Furdzik,

Bednarek,

Hibner

et al. 2023

Metabolites

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Background: The predictive role of vitamin D (VD) in breast cancer (BC) patients’ survival is still being investigated. This paper aims to evaluate the changes in VD metabolites during chemotherapy (CTH) and the predictive role of VD status in Caucasian BC patients treated with CTH. Methods: Vitamin D and its metabolites were assessed with reference LC–MS/MS methodology in 98 consecutive BC patients starting CHT, after 3 and 6 months, and compared to the control group. Results: The frequency of VD deficiency in BC patients was greater than in the control group (56.1% vs. 37.2%). After 6 months of CTH, the number of VD-deficient BC patients slightly increased to 60%. The concentrations of VD active forms [25(OH)D2, 25(OH)D3], and catabolites [24,25(OH)2D3 and 3-epi-25(OH)D3] decreased after 3 and 6 months of CTH compared to the baseline values. Strong positive correlations between concentrations of 3-epi-25(OH)D3 and 25(OH)D in both groups were found. Similar correlations were also observed between 24,25(OH)2D3 and 25(OH)D levels. Kaplan–Meier survival analysis showed significantly longer survival in BC patients without deficiency (>20 ng/mL) at baseline (HR = 2.44 (95% CI 1.07–5.59), p = 0.026). Conclusions: (1) Our data provide further evidence that BC patients before CTH are more VD-deficient than the general population and this deficiency increases further during CTH treatment, as observed using the reference LC-MS methodology. (2) Presented results show that VD catabolism is not affected in BC patients. (3) The poorer survival in VD-deficient BP patients supports the importance of VD supplementation in BC patients with 25(OH)D levels below 20 ng/mL.

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Prevalence and Cause of Enamel Hypoplasia in Primary Teeth among 1-year-old Japanese Children

Miyamoto¹,

Minagawa²,

Nohno³

et al. 2023

TODENTJ

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Objective: In this study, the prevalence and underlying cause of enamel hypoplasia in one-year-old children were examined. Additionally, to determine the association between enamel hypoplasia and exposure to sunlight based on the frequency of the mother’s outings during pregnancy. Methods: A total of 273 kids (139 boys) were involved in this study. Based on questionnaires surveys to mothers, oral examinations, and photographs of children's mouths, we looked at the connection between the circumstances of pregnancy and the occurrence of enamel hypoplasia. The presence of enamel hypoplasia was assessed using logistic regression analysis differed among the results of the questionnaire. Results: The prevalence of enamel hypoplasia was 38.5%. In the medium and low groups, enamel hypoplasia was more common than in the high group at the birth month of the child (adjusted odds ratio: 3.36, 95% confidence interval: 1.65–6.85, p = 0.001 vs. adjusted odds ratio: 3.76, 95% confidence interval: 1.89–7.48, p < 0.001, respectively). Enamel hypoplasia was knowingly higher among the children whose mothers went out less than 1–2 times a week during pregnancy (adjusted odds ratio: 2.41, 95% confidence interval: 1.04–5.61, p = 0.041). Enamel hypoplasia was significantly more prevalent when mothers used painkillers during pregnancy (adjusted odds ratio: 5.45, 95% Confidence interval: 1.74–17.08, p = 0.004). Conclusion: It was suggested that the use of antipyretic analgesics during pregnancy and frequency of outings and variations in sunshine hours according to the child's birth month could affect the occurrence of enamel hypoplasia.

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Impact of serum vitamin D on the response and prognosis in breast cancer patients treated with neoadjuvant chemotherapy

Cited by 5 publications

References 31 publications

Postdiagnosis dietary factors, supplement use and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

Postdiagnosis dietary factors, supplement use and breast cancer prognosis: Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis

Vitamin D and Its Metabolites Status before and during Chemotherapy in Caucasian Breast Cancer Patients

Prevalence and Cause of Enamel Hypoplasia in Primary Teeth among 1-year-old Japanese Children

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