Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets

Abstract

Enamel demineralisation can occur as a side effect during orthodontic treatment with fixed appliances. This study aimed to evaluate the efficacy of the self-assembling peptide P11-4 for remineralisation combined with fluorides, compared to application of fluoride varnish alone. De- and remineralisation was assessed by Quantitative light-induced fluorescence (QLF). Orthodontic brackets were bonded on 108 human enamel samples and white spot lesions were created. The samples were allocated randomly into three groups: Group I received no treatment, group II had a single application of fluoride varnish (22,600 ppm), and group III was treated with P11-4 following a single application of fluoride varnish. Quantitative light-induced fluorescence (QLF) measurements were performed at baseline, after demineralisation and after storage in remineralisation solution for 7 and 30 days. Non-parametric tests (Kruskal–Wallis test and Friedman test) were used for further analysis. After demineralisation, all samples showed a median ΔF -9.38% ± 2.79. After 30 days median ΔF values were as followed: group I = -9.04% ± 2.51, group II = -7.89 ± 2.07, group III = -6.08% ± 2.79). The median ΔF values differed significantly between all groups at all investigation times (p < 0.00001). Application of P11-4 with fluoride varnish was superior to the use of fluorides alone for remineralisation of enamel adjacent to brackets.

Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment—An Open Label Randomized Controlled Trial

“…There are many approaches used to prevent enamel demineralization during orthodontic treatment [53,54] and the post-orthodontic stage [55,56] and to obtain remineralization on demineralized surfaces [57]. Some of them include the use and application of fluorinecontaining agents [13,14], casein phosphopeptide containing agents [17], and antimicrobial agents [15,16].…”

Re Mineralise the Demineralised: How Knowledgeable and Aware are our Dentists in Kashmir Related to this Minimally Invasive Technique

“…BIOMIMETIC remineralising agents like self assembling peptides are considered to be very helpful in caries prevention as self assembling peptide P11-4 commercially available as Curo lox and Curodont Repair were developed for the in depth biomimetic treatment of the initial carious lesions [15].…”

Effectiveness of Self-Assembling Peptide (P11-4) in Dental Hard Tissue Conditions: A Comprehensive Review

“…In vitro efficacy of the P11-4 for remineralisation combined with fluorides, compared to the application of fluoride varnish alone Application of P11-4 with fluoride varnish was superior to the use of fluorides alone for remineralisation of enamel adjacent to brackets Enamel [45] 14…”