Impact of SARS‐CoV‐2 on multiple gestation pregnancy

Mahajan, Niraj N.; Ansari, Munira; Gaikwad, Chaitanya; Jadhav, Priyanka; Tirkey, Deepika; Pophalkar, Madhura; Bhurke, Aishwarya V.; Modi, Deepak; Mahale, Smita D.; Gajbhiye, Rahul

doi:10.1002/ijgo.13508

Cited by 16 publications

(11 citation statements)

References 12 publications

(20 reference statements)

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“…However, these reported studies have yielded conflicting findings leading to contradictory conclusions. Some reports indicate that there are no major adverse outcomes of SARS‐CoV‐2 infection in pregnancy, 4,5 others have reported serious pregnancy complications such as preterm births, neurological disorders, miscarriages, and maternal deaths in women infected with SARS‐COV2 during pregnancy 6‐13 . Multiple systematic reviews have been conducted that have majorly described the risk of vertical transmission and maternal presentation associated with COVID‐19.…”

Section: Introductionmentioning

confidence: 99%

Differential impact of COVID‐19 in pregnant women from high‐income countries and low‐ to middle‐income countries: A systematic review and meta‐analysis

Gajbhiye

Sawant

Kuppusamy

et al. 2021

Intl J Gynecology & Obste

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Background SARS‐CoV‐2 has infected a large number of pregnant women. Objective To compare clinical, perinatal outcomes of women with COVID‐19 from high‐income countries (HICs) and low‐ to middle‐income countries (LMICs). Search strategy Online databases were searched. Selection criteria Original studies on pregnant women with COVID‐19 were included. Data collection and analysis Information on clinical presentation, co‐morbidities, pregnancy outcomes, neonatal outcomes, and SARS‐CoV‐2 infection in neonates was extracted. Main results The pooled estimate of SARS‐CoV‐2 positive neonates is 3.7%. Symptomatic presentations are less common in LMICs compared to HICs (odds ratio [OR] 0.38). Diabetes (OR 0.5), hypertension (OR 0.5), and asthma (OR 0.14) are commonly reported from HICs; hypothyroidism (OR 2.2), anemia (OR 3.2), and co‐infections (OR 6.0) are commonly reported in LMICs. The overall risk of adverse pregnancy outcomes is higher in LMICs compared to HICs (OR 2.4). Abortion (OR 6.2), stillbirths (OR 2.0), and maternal death (OR 7.8) are more common in LMICs. Preterm births and premature rupture of membranes are comparable in both groups. Neonatal deaths (OR 3.7), pneumonia (OR 7.5), and neonatal SARS‐CoV‐2 infection (OR 1.8) are commonly reported in LMICs. Conclusions In LMICs, pregnant women and neonates are more vulnerable to adverse outcomes due to COVID‐19. PROSPERO registration no: CRD42020198743.

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Section: Introductionmentioning

confidence: 99%

Differential impact of COVID‐19 in pregnant women from high‐income countries and low‐ to middle‐income countries: A systematic review and meta‐analysis

Gajbhiye

Sawant

Kuppusamy

et al. 2021

Intl J Gynecology & Obste

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“…Gurol-Urganci and colleagues [ 32 ] showed a higher risk of pre-eclampsia in SARS-CoV-2-infected patients in their study (3.9%; p < 0.001). Mahajan et al [ 33 ] evaluated the effect of COVID-19 on multiple gestation pregnancies. Based on their study, the risk of pre-eclampsia/eclampsia was higher in MGPs with COVID-19 than MGPs before the pandemic (50.0% vs. 12.7%) and singleton pregnancies (41.6% vs. 7.9%).…”

Section: Resultsmentioning

confidence: 99%

Cardiovascular Complications of COVID-19 among Pregnant Women and Their Fetuses: A Systematic Review

Yaghoobpoor

Fathi

Vakili

et al. 2022

JCM

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Background: COVID-19 is a viral infectious disease leading to a spectrum of clinical complications, especially cardiovascular. Evidence shows that this infection can potentially accompany a worse outcome in pregnant women. Cardiovascular complications in mothers and their fetuses are reported by previous studies. Objective: In this systematic review, we aim to investigate the cardiovascular complications of COVID-19 during pregnancy in the mothers and fetus, according to the published literature. Method: We systematically searched the online databases of PubMed, Scopus, Web of Science, and Google Scholar, using relevant keywords up to April 2022. We included all observational studies reporting cardiovascular complications among COVID-19-affected pregnant women and their fetuses. Results: We included 74 studies containing 47582 pregnant COVID-19 cases. Pre-eclampsia, hypertensive disorders, cardiomyopathy, heart failure, myocardial infarction, thrombosis formation, alterations in maternal–fetal Doppler patterns, and maternal and fetal arrhythmia were reported as cardiovascular complications. The highest incidences of pre-eclampsia/eclampsia among COVID-19 pregnant cases, reported by studies, were 69% and 62%, and the lowest were 0.5% and 3%. The highest and lowest incidences of fetal bradycardia were 20% and 3%, and regarding fetal tachycardia, 5.4% and 1%, respectively. Conclusion: SARS-CoV-2 infection during pregnancy can potentially be associated with cardiovascular complications in the mother, particularly pre-eclampsia and heart failure. Moreover, SARS-CoV-2 infection during pregnancy can potentially cause cardiovascular complications in the fetus, particularly arrhythmia.

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“…A similar increased rate of severe disease and maternal mortality has been recently reported in the American population, suggesting that pregnant women should be considered a high-risk population for COVID-19 until proven otherwise [ 11 ]. It has been previously reported that infected women with twin gestations did not present with severe disease as compared to their singleton counterparts [ 12 ]. Our study had three twins and their mothers did not experience severe disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile of SARS-CoV-2-Infected Neonates

Kulkarni¹,

Valvi²,

Dawre³

et al. 2022

Cureus

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BackgroundThere are conflicting data on the mother-to-child transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and few studies have described the clinical course of neonates infected with SARS-CoV-2. ObjectivesThis study investigates the mother-to-child transmission rate and clinical profile of SARS-CoV-2-infected newborns. MethodsData on 304 newborns of 301 mothers with coronavirus disease 2019 (COVID-19) were prospectively collected and analyzed. Reverse transcription-polymerase chain reaction (RT-PCR) determined the presence of SARS-CoV-2 in the placenta, umbilical cord stump, and nasopharyngeal swabs collected within 24h of birth. Clinical and laboratory data of SARS-CoV-2-infected newborns was entered in a structured proforma. ResultsA total of 20 neonates (6.5%) were positive for SARS-CoV-2, of which 12 were positive only in the nasopharyngeal swab, four cases had the umbilical stump positive, three were positive in the placenta, and one case was positive in all the three specimens collected. Six of the 20 SARS-CoV-2-positive neonates developed severe symptoms. The SARS-CoV-2-positive symptomatic neonates required a more extended stay in hospital compared to their non-symptomatic infected counterparts. ConclusionsA proportion of the babies born to SARS-CoV2-infected mothers tested positive and some of these newborns had severe symptoms.

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Impact of SARS‐CoV‐2 on multiple gestation pregnancy

Cited by 16 publications

References 12 publications

Differential impact of COVID‐19 in pregnant women from high‐income countries and low‐ to middle‐income countries: A systematic review and meta‐analysis

Differential impact of COVID‐19 in pregnant women from high‐income countries and low‐ to middle‐income countries: A systematic review and meta‐analysis

Cardiovascular Complications of COVID-19 among Pregnant Women and Their Fetuses: A Systematic Review

Clinical Profile of SARS-CoV-2-Infected Neonates

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