Impact of SARS-CoV-2 on Host Factors Involved in Mental Disorders

Rhoades, Raina; Solomon, Sarah H.; Johnson, Christina; Teng, Shaolei

doi:10.3389/fmicb.2022.845559

Cited by 6 publications

(3 citation statements)

References 238 publications

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“…Studies have shown that the SARS-CoV-2 to be present in the cerebrovascular fluid in patients with COVID-19 [ 51 ], and affects the patient’s brain findings in autopsies [ 52 ], providing evidence of the neurotropic effect and involvement in COVID-19 infection. Indeed, systemic inflammation has been attributed to cause neuropsychological and mental health symptoms such as depression, anxiety and cognitive defects [ 53 ]. In a prospective cohort study among adults, systemic inflammation scores predicted depression and cognitive impairment at three months, which signifies that the inflammation caused by COVID-19, predisposes patients to depression and cognitive problems [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of mental health problems among children with long COVID: A systematic review and meta-analysis

et al. 2023

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Introduction The number of children with mental health problems has more than doubled since the COVID-19 pandemic. However, the effect of long Covid on children’s mental health is still debatable. Recognising long Covid as a risk factor for mental health problems in children will increase awareness and screening for mental health problems following COVID-19 infection, resulting in earlier intervention and lower morbidity. Therefore, this study aimed to determine the proportion of mental health problems post-COVID-19 infection in children and adolescents, and to compare them with the population with no previous COVID-19 infection. Methodology A systematic search was done in seven databases using pre-defined search terms. Cross-sectional, cohort and interventional studies reporting the proportion of mental health problems among children with long COVID in the English language from 2019 to May 2022 were included. Selection of papers, extraction of data and quality assessment were done independently by two reviewers. Studies with satisfactory quality were included in meta-analysis using R and Revman software programmes. Results The initial search retrieved 1848 studies. After screening, 13 studies were included in the quality assessments. Meta-analysis showed children who had previous COVID-19 infection had more than two times higher odds of having anxiety or depression, and 14% higher odds of having appetite problems, compared to children with no previous infection. The pooled prevalence of mental health problems among the population were as follows; anxiety: 9%(95% CI:1, 23), depression: 15%(95% CI:0.4, 47), concentration problems: 6%(95% CI: 3, 11), sleep problems: 9%(95% CI:5, 13), mood swings: 13% (95%CI:5, 23) and appetite loss: 5%(95% CI:1, 13). However, studies were heterogenous and lack data from low- and middle-income countries. Conclusion Anxiety, depression and appetite problems were significantly increased among post-COVID-19 infected children, compared to those without a previous infection, which may be attributed to long COVID. The findings underscore the importance of screening and early intervention of children post-COVID-19 infection at one month and between three to four months.

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Section: Discussionmentioning

confidence: 99%

Prevalence of mental health problems among children with long COVID: A systematic review and meta-analysis

et al. 2023

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“…Hyposmia and hypogeusia were noted as symptoms observed in individuals diagnosed with COVID-19, with reported Angiogenesis is generally accompanied by inflammation, which causes an increase in vascular permeability and the recruitment of inflammatory cells [116]. The ACE2 enzyme plays a crucial role in the catalytic process of converting Ang I and Ang II, Ang I to Ang 1-9 and Ang II to Ang 1-7, respectively [117,118]. When the SARS-CoV-2 virus interacts with ACE2, it can deactivate this enzyme, which may cause an increase in the activation of the ACE/AngII/AT1R axis, subsequently leading to the excessive synthesis of AngII.…”

Section: Neurologic Symptoms Of Sars-cov-2 Infectionmentioning

confidence: 99%

SARS-CoV-2 and Brain Health: New Challenges in the Era of the Pandemic

Ahmed,

Feng,

Zhang

et al. 2023

Microorganisms

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Respiratory viral infections have been found to have a negative impact on neurological functions, potentially leading to significant neurological impairment. The SARS-CoV-2 virus has precipitated a worldwide pandemic, posing a substantial threat to human lives. Growing evidence suggests that SARS-CoV-2 may severely affect the CNS and respiratory system. The current prevalence of clinical neurological issues associated with SARS-CoV-2 has raised significant concerns. However, there needs to be a more comprehensive understanding of the specific pathways by which SARS-CoV-2 enters the nervous system. Based on the available evidence, this review focuses on the clinical neurological manifestations of SARS-CoV-2 and the possible mechanisms by which SARS-CoV-2 invades the brain.

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“…Furthermore, the SARS-CoV-2 N protein has been shown to inhibit RIG-1-like pathway. RIG-1 (retinoid acidinducible gene-1) has been found to have associations with schizophrenia suggesting that coronavirus infection could lead to exacerbation of previous neuropsychiatric illness (Rhoades et al, 2022). Moving forward, more research is required to clarify the exact mechanisms underlying the associations between COVID-19-related olfactory dysfunction and neuropsychiatric disorders.…”

Section: Neuropsychiatric Symptomsmentioning

confidence: 99%

Assessment of COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, and cognitive symptoms

Jegatheeswaran,

Gokani,

Luke

et al. 2023

Front. Neurosci.

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Purpose of reviewTo provide a detailed overview of the assessment of COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, and cognitive symptoms.Recent findingsCOVID-19-related olfactory dysfunction can have a detrimental impact to the quality of life of patients. Prior to the COVID-19 pandemic, olfactory and taste disorders were a common but under-rated, under-researched and under-treated sensory loss. The pandemic has exacerbated the current unmet need for accessing good healthcare for patients living with olfactory disorders and other symptoms secondary to COVID-19. This review thus explores the associations that COVID-19 has with psychological, neuropsychiatric, and cognitive symptoms, and provide a framework and rationale for the assessment of patients presenting with COVID-19 olfactory dysfunction.SummaryAcute COVID-19 infection and long COVID is not solely a disease of the respiratory and vascular systems. These two conditions have strong associations with psychological, neuropsychiatric, and cognitive symptoms. A systematic approach with history taking and examination particularly with nasal endoscopy can determine the impact that this has on the patient. Specific olfactory disorder questionnaires can demonstrate the impact on quality of life, while psychophysical testing can objectively assess and monitor olfaction over time. The role of cross-sectional imaging is not yet described for COVID-19-related olfactory dysfunction. Management options are limited to conservative adjunctive measures, with some medical therapies described.

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Impact of SARS-CoV-2 on Host Factors Involved in Mental Disorders

Cited by 6 publications

References 238 publications

Prevalence of mental health problems among children with long COVID: A systematic review and meta-analysis

Prevalence of mental health problems among children with long COVID: A systematic review and meta-analysis

SARS-CoV-2 and Brain Health: New Challenges in the Era of the Pandemic

Assessment of COVID-19-related olfactory dysfunction and its association with psychological, neuropsychiatric, and cognitive symptoms

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