Impact of saffron (Crocus Sativus Linn) supplementation and resistance training on markers implicated in depression and happiness levels in untrained young males

Moghadam, Babak Hooshmand; Bagheri, Reza; Roozbeh, Behnam; Ashtary‐Larky, Damoon; Gaeini, Abbas Ali; Dutheil, Frédéric; Wong, Alexei

doi:10.1016/j.physbeh.2021.113352

Cited by 23 publications

(26 citation statements)

References 41 publications

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“…Depression includes the dysregulation of the dopaminergic system [ 23 , 40 ]. Thus, we checked the dopamine release in our human neuron cultures.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, saffron was very recently reported in clinic as synergistically increasing both serotonin and dopamine levels in serum when combined with endurance exercise in young adults [ 40 ]. In agreement with these data, we consistently found that the circulating metabolites from saffron were able to stimulate both serotonin and dopamine production in human neurons in both the presence and the absence of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

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Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

Wauquier¹,

Boutin-Wittrant²,

Pourtau

et al. 2022

Nutrients

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Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’InsideTM) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression.

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“…Depression includes the dysregulation of the dopaminergic system [ 23 , 40 ]. Thus, we checked the dopamine release in our human neuron cultures.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

Wauquier¹,

Boutin-Wittrant²,

Pourtau

et al. 2022

Nutrients

View full text Add to dashboard Cite

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“…Crocin has a long history of medicinal use and has produced favorable outcomes in clinical and preclinical trials in CNS disorders including AD, PD, ischemia, mood disorders and LPS-induced cognitive decline (Rajaei et al, 2016, Zhang et al, 2018, Haeri et al, 2019, Zhang et al, 2019, Azmand and Rajaei 2021). The therapeutic benefits of crocin in subjects with depression have been attributed to the induction of neurortophins expression including brain-derived neurotropic factor (BDNF) (Ghasemi et al, 2015, Moghadam et al, 2021). This property of crocin may prove useful for HD considering the role of HTT in BDNF expression and transport, biological activities that are diminished in neurons expressing mutant HTT (Zuccato and Cattaneo, 2014).…”

Section: Discussionmentioning

confidence: 99%

Gut bacteria regulate the pathogenesis of Huntington’s disease in Drosophila model

Chongtham

Yoo

Chin

et al. 2021

Preprint

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Changes in the composition of gut microbiota are implicated in the pathogenesis of several neurodegenerative disorders. Here, we investigated whether gut bacteria affect the hallmarks of Huntington's disease (HD) in transgenic Drosophila melanogaster (fruit fly) models expressing human full-length or N-terminal fragments of mutant huntingtin (HTT) protein, here referred to as HD flies. We find that elimination of commensal gut bacteria by antibiotics reduces the aggregation of amyloidogenic N-terminal fragments of HTT and delays the development of motor defects. Conversely, colonization of HD flies with Escherichia coli (E. coli), a known pathobiont of human gut, accelerates HTT aggregation, aggravates immobility and shortens life span. Similar to antibiotics, treatment of HD flies with compounds such as luteolin, a flavone, or crocin a beta-carotenoid, ameliorates disease phenotypes and promotes survival. Crocin prevents colonization of E. coli in the HD flies gut and alters the levels of commensal bacteria, which may be linked to its protective effects. The opposing effects of E. coli and crocin on HTT aggregation, motor defects and survival in transgenic Drosophila support the involvement of gut-brain networks in the pathogenesis of HD.

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“…Nevertheless, drug stability and bioavailability should be increased to not hamper the desirable administration route of oral ingestion. Nanocarriers have been demonstrated to be applicable aids in biological delivery processes [ 119 , 123 , 127 ]. Various matrices have been shown to increase and retain crocins, increasing delivery and stability ( Table 4 ).…”

Section: Pharmacological Treatment Of Depression With Crocinmentioning

confidence: 99%

Anti-Depressant Properties of Crocin Molecules in Saffron

et al. 2022

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Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subject of this paper. Crocins have been demonstrated to act as a monoamine oxidase type A and B inhibitor. Furthermore, saffron petal extracts have experimentally been shown to impact contractile response in electrical field stimulation. Other research suggests that saffron also inhibits the reuptake of monoamines, exhibits N-methyl-d-aspartate antagonism, and improves brain-derived neurotrophic factor signaling. A host of experimental studies found saffron/crocin to be similarly effective as fluoxetine and imipramine in the treatment of depression disorders. Saffron and crocins propose a natural solution to combat depressive disorders. However, some hurdles, such as stability and delivery, need to be overcome.

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Impact of saffron (Crocus Sativus Linn) supplementation and resistance training on markers implicated in depression and happiness levels in untrained young males

Cited by 23 publications

References 41 publications

Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

Gut bacteria regulate the pathogenesis of Huntington’s disease in Drosophila model

Anti-Depressant Properties of Crocin Molecules in Saffron

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