Anti-Depressant Properties of Crocin Molecules in Saffron

Siddiqui, Shahida Anusha; Redha, Ali Ali; Snoeck, Edgar Remmet; Singh, Shubhra; Simal-Gándara, Jesús; Ibrahim, Salam A.; Jafari, Seid Mahdi

doi:10.3390/molecules27072076

Cited by 44 publications

(31 citation statements)

References 112 publications

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“…The safety of saffron and its metabolites have been evaluated in clinical trials of both adult and pediatric patients, administered mainly p.o. , in different dosages or formulations (14–450 mg of saffron, 5–30 mg of CRCs, or 7.5–37.5 mg of CRT) [ 143 , 144 , 145 ]. Administration of Crocus sativus L. stigma tablets (200 and 400 mg/day, for 7 days) in healthy adult volunteers, was safe, without significantly affecting any hematological, biochemical and coagulation parameters [ 146 , 147 , 148 ].…”

Section: Discussionmentioning

confidence: 99%

An In Vitro Study of Saffron Carotenoids: The Effect of Crocin Extracts and Dimethylcrocetin on Cancer Cell Lines

et al. 2022

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Crocus sativus L. has various pharmacological properties, known for over 3600 years. These properties are attributed mainly to biologically active substances, which belong to the terpenoid group and include crocins, picrocrocin and safranal. The aim of the current work was to examine the effects of crocins (CRCs) and their methyl ester derivate dimethylcrocetin (DMCRT) on glioblastoma and rhabdomyosarcoma cell lines, in terms of cytotoxicity and gene expression, implicated in proapoptotic and cell survival pathways. Cell cytotoxicity was assessed with Alamar Blue fluorescence assay after treatment with saffron carotenoids for 24, 48 and 72 h and concentrations ranging from 22.85 to 0.18 mg/mL for CRCs and 11.43 to 0.09 mg/mL for DMCRT. In addition, BAX, BID, BCL2, MYCN, SOD1, and GSTM1 gene expression was studied by qRT-PCR analysis. Both compounds demonstrated cytotoxic effects against glioblastoma and rhabdomyosarcoma cell lines, in a dose- and time-dependent manner. They induced apoptosis, via BAX and BID upregulation, MYCN and BCL-2, SOD1, GSTM1 downregulation. The current research denotes the possible anticancer properties of saffron carotenoids, which are considered safe phytochemicals, already tested in clinical trials for their health promoting properties.

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Section: Discussionmentioning

confidence: 99%

An In Vitro Study of Saffron Carotenoids: The Effect of Crocin Extracts and Dimethylcrocetin on Cancer Cell Lines

et al. 2022

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“…The main coloring and biologically active components of saffron are the water-soluble carotenoids crocin and crocetin. The high biological activity of crocin and the prospect of using it for the treatment of eye diseases (glaucoma, macular degeneration, diabetic retinopathy, and age-related macular degeneration) [61], as an antidepressant [62], and an anticancer substance [63] have been revealed.…”

Section: Literature Review and Problem Statementmentioning

confidence: 99%

Investigation of the characteristics of Zn-Al layered double hydroxides, intercalated with natural dyes from spices, as a cosmetic pigments

Кovalenko

Kotok

Borysenko³

et al. 2022

EEJET

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Pigments are the main components of cosmetics, which determine both toxicity and consumer color characteristics. Zn-Al layered double hydroxides intercalated with anionic food dyes are promising pigments. The best sources of dyes for intercalation are natural ones. The most promising are spices. Natural dyes from spices are often biologically active substances. The parameters of samples of Zn-Al (Zn:Al=3:1) hydroxides intercalated with natural food dyes, synthesized in the medium of aqueous tinctures of saffron and safflower, were studied. The crystal structure of the samples was studied by X-ray phase analysis; color characteristics were studied by spectroscopy and calculation of parameters in the CIE L*a*b system. The possibility of synthesizing Zn-Al colored layered double hydroxides intercalated with natural dyes in the medium of saffron and safflower tinctures was shown. X-ray phase analysis showed that both pigment samples were layered double hydroxides with the α-Zn(OH)2 structure. For the pigment intercalated with saffron dye, the phenomenon of partial decomposition of Zn-Al LDH to ZnO during synthesis was revealed. The color characteristics of the samples were studied. Zn-Al LDH pigment synthesized in a saffron tincture had a bright yellow color determined by intercalated saffron carotenoids (crocin and crocetin). It was suggested that safflower dye flavonoids were partially hydrolyzed (red ones - cartamine and cartamidine, and yellow - Safflor Yellow A), which led to the formation of a dark orange-brown color of the sample. The prospects of using Zn-Al LDH intercalated with saffron food dyes as a cosmetic pigment were shown

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“…Gluten sensitivity without celiac disease is another exciting concept. Some patients with irritable bowel syndrome and functional dyspepsia who do not have signs of gluten disease experience a significant improvement in symptoms after excluding gluten from their diet [15,16]. Basic principles of treatment of functional disorder of the gastrointestinal tract in anxiety disorders are showed in Table 1.…”

Section: The Role Of Dietmentioning

confidence: 99%

Possibilities of Correction of Functional Disorders of the Gastrointestinal Tract in Patients with Anxiety Disorders

Volodikhina¹,

Akhmedova²,

Uzdenov³

et al. 2022

Pharmacophore

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Functional disorders of the gastrointestinal tract have recently occupied a niche of the most common diagnoses in gastroenterology, recognized by morphological and physiological abnormalities. Functional disorders of the gastrointestinal tract are a heterogeneous group of disorders, including not only symptoms characteristic of functional dyspepsia (14.6%) in combination with changes in intestinal motility but also irritable bowel syndrome (irritable bowel syndrome, 31.7%) and constipation. These are diseases classified by gastrointestinal manifestations, including one of the following symptoms: impaired motor skills, visceral hypersensitivity, changes in the function of the mucous membrane and the immune system, changes in the intestinal microbiota, and changes in the processing of the central nervous system. According to several studies, mental disorders such as depression and anxiety are often accompanied by functional disorders of the gastrointestinal tract. Thus, it can be concluded that functional disorders of the gastrointestinal tract require a multidisciplinary approach for timely diagnosis and treatment. A recent global Internet survey of the Rome Foundation, in which 127 54 people from 26 countries participated, reported that 32 112 (43%) of the respondents met the criteria for at least one of the manifestations of functional disorders of the gastrointestinal tract. Given the high prevalence of the disease, it is necessary to clearly understand the possibilities of correcting functional disorders of the gastrointestinal tract. This will allow researchers and practitioners to approach the treatment and prevention of this pathology more meaningfully.

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Anti-Depressant Properties of Crocin Molecules in Saffron

Cited by 44 publications

References 112 publications

An In Vitro Study of Saffron Carotenoids: The Effect of Crocin Extracts and Dimethylcrocetin on Cancer Cell Lines

An In Vitro Study of Saffron Carotenoids: The Effect of Crocin Extracts and Dimethylcrocetin on Cancer Cell Lines

Investigation of the characteristics of Zn-Al layered double hydroxides, intercalated with natural dyes from spices, as a cosmetic pigments

Possibilities of Correction of Functional Disorders of the Gastrointestinal Tract in Patients with Anxiety Disorders

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