Impact of rotavirus vaccination on childhood deaths from diarrhea in Brazil

Abstract

The decreased rates of childhood gastroenteritis-related deaths in Brazil following rotavirus vaccine introduction, particularly among children <1 year of age, suggest the potential benefit of vaccination.

Effect of pentavalent rotavirus vaccine introduction on hospital admissions for diarrhoea and rotavirus in children in Rwanda: a time-series analysis

“…[4][5][6] Similar decreases of 17-39% in Brazil and 50% in Panama were documented after rotavirus vaccine introduction. [7][8][9] Additionally, many other countries have noted a substantial reduction in the number of hospital admissions for all-cause diarrhoea and rotavirus after the rotavirus vaccine introduction. 7, Live oral vaccines, including those for rotavirus, have had poor performance in developing country settings.…”

Post-licensure experience with rotavirus vaccination in high and middle income countries; 2006 to 2011

“…In subsequent years, these mortality benefits were sustained and broadened to older children aged 1-4 years, who by that time had been eligible for vaccination as infants [31 ]. Similar patterns have been observed in Brazil where two separate studies estimated mortality declines of 41% [24 ] and 22% [23 ]. The latter study in Brazil used statistical methods controlling for the secular declines in mortality that have occurred in Brazil over recent years [32].…”

Vaccination Against Rotavirus Infection: 10-Year Global Experience of Successful Use

“…В ряде государств, таких как Мексика, Бразилия и Панама, внедрение иммунизации против ротавирус-ной инфекции в национальный календарь прививок сопровождалось существенным снижением уровня смертности от диареи на 22-50% среди детей до 5-лет-него возраста [45,48,53,54].…”

“…Таким образом, внедрение ротавирусной вакцина-ции за последние 5 лет в странах Латинской Америки, Африки и Азии параллельно с эффективными меропри-ятиями эпидемиологического надзора, проводимыми GRSN, предоставили отличную возможность оценить эффективность ротавирусных вакцин в пострегистра-ционный период. В частности, пострегистрационные исследования, проведенные в большинстве государств Латинской Америки в результате внедрения иммуниза-ции в национальные календари, подтвердили эффектив-ность ротавирусных вакцин [45,48,53,54].…”