Impact of rotavirus vaccination on diarrhea-related hospitalizations in São Paulo State, Brazil

Fernandes, Eder Gatti; Sato, Helena Keico; Leshem, Eyal; Flannery, Brendan; Konstantyner, Thais Cláudia Roma de Oliveira; Veras, Maria Amélia; Patel, Manish

doi:10.1016/j.vaccine.2014.04.015

Cited by 28 publications

(16 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This vaccine has led to a decline in hospitalizations caused by diarrhea and in mortality rates in low-and middle-income countries. [8,43,44] In Brazil, this vaccine was incorporated in the National Immunization Program in April 2006, with two recommended doses at two and four months of age. It is important to highlight that the data gathering in this survey occurred in this same year, so it is probable that the majority of the children in the sample were not vaccinated at the time of the interview, which limits the ability to compare disease occurrence and hospitalization rates with figures from recent research.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and hospitalization rates due to diarrhoea in infants: the 2006 Brazilian National Demographic Health Survey

Konstantyner

Konstanty

Mais

et al. 2015

JER

View full text Add to dashboard Cite

Aim: The aim of this study was to estimate the prevalence of and hospitalization rate due to diarrhea and to identify factors associated with diarrheal disease and related hospitalizations in children less than two years old in Brazil. Methods: This was a cross-sectional study of 1,902 children who were participants in the 2006 National Demographic and Health Survey (Pesquisa Nacional de Demografia e Saúde da Criança e da Mulher -PNDS 2006). To collect data, children's mothers were interviewed. The prevalence of and hospitalization rate due to diarrhea were calculated for the two weeks before the interview and for the last year, respectively. Logistic regression models were fitted to identify the prevalence of diarrhea and the risk factors associated with diarrhea occurrence and related hospitalizations. A complex sample statistical technique was applied for all analyses. Results: The prevalence of diarrhea and hospitalization rate due to diarrhea were 11.9% and 2.6%, respectively. Children living in the North and Northeast regions had a greater risk of diarrhea, while children under 12 months old, those who were receiving age-appropriate exclusive breastfeeding and those with mothers greater than 35 years old were protected against the disease. Male children living in households that did not have a land-floor in the North and Northeast regions had a higher risk of hospitalization due to diarrhea, while children of mothers who had a higher education level (> 4 years) were protected against it. Conclusion: Diarrhea is still a public health problem for children under two years old in Brazil, especially in the North and Northeast regions. Diarrhea control and prevention programs should inform young mothers with lower education levels about children's healthcare, including the benefits of breastfeeding.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and hospitalization rates due to diarrhoea in infants: the 2006 Brazilian National Demographic Health Survey

Konstantyner

Konstanty

Mais

et al. 2015

JER

View full text Add to dashboard Cite

show abstract

“…The final complete dataset for children 0-1 years of age included 15 studies [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] from six countries (United States, Brazil, Nicaragua, El Salvador, Panama, Mexico). While our initial search and coding included data for children under 5, data points for children older than 1 year of age were excluded due to inconsistencies between mortality and coverage data, and in order to include the largest number of studies possible given the variability across studies in how age groups were divided.…”

Section: Data Abstraction Synthesis and Analysismentioning

confidence: 99%

Estimating the herd immunity effect of rotavirus vaccine

Pollard

Malpica-Llanos

Friberg

et al. 2015

Vaccine

View full text Add to dashboard Cite

show abstract

“…Impact studies conducted in Brazil using data from the Datasus have shown a reduction of hospital admissions due to acute diarrhea in children less than 5 years of age. In Brazil, the reduction ranged from 17 to 21.4%; 12,20 in the South and Southeast region, the reduction was 35% in the year 2007; 21 in the Southeast region the reduction was 21%; 12 and in the State of São Paulo the reduction ranged from 21 to 40%. 13,22 In the peak period of rotavirus infection (May and June), the reduction in hospital admissions due to acute diarrhea after the introduction of the vaccine was 82%, suggesting that the effectiveness of the vaccine was good.…”

Section: Discussionmentioning

confidence: 96%

“…10 After the introduction of the vaccine in Brazil, two studies used the National Health Information System (Datasus) and showed there was a 21% reduction in hospital admissions due to acute diarrhea in the Southeast, 11 and a reduction of 40% in the state of São Paulo. 12 Another study at a private hospital in the city of São Paulo showed a 59% reduction in hospital admissions due to acute diarrhea caused by rotavirus in children less than 5 years of age. 13 However, there are still no studies evaluating the impact of the rotavirus vaccine at public hospitals in the city of São Paulo.…”

mentioning

confidence: 99%

The impact of rotavirus vaccination on emergency department visits and hospital admissions for acute diarrhea in children under 5 years

Paulo

Rodrigues²,

Machado

et al. 2016

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

We screened the main diagnosis of all ED attendances and hospital admissions of children under 5 years in an electronic registry system database and calculated the rates of ED visits and hospital admissions. The reduction rate was analyzed according to the following formula: reduction (%) = (1 -odds ratio) x 100. Results: The rates of ED visits for acute diarrhea was 85.8 and 80.9 per 1,000 total ED visits in the pre and post vaccination periods, respectively, resulting in 6% reduction (95CI 4 to 9%, p<0.001). The rates of hospital admissions for acute diarrhea was 40.8 per 1,000 in the pre-vaccine period and dropped to 24.9 per 1,000 hospitalizations, resulting in 40% reduction (95CI 22 to 54%, p<0.001). Conclusion:The introduction of the RV1 vaccine resulted in 6% reduction in the ED visits and 40% reduction in hospital admissions for acute diarrhea.

show abstract

Impact of rotavirus vaccination on diarrhea-related hospitalizations in São Paulo State, Brazil

Cited by 28 publications

References 19 publications

Prevalence and hospitalization rates due to diarrhoea in infants: the 2006 Brazilian National Demographic Health Survey

Prevalence and hospitalization rates due to diarrhoea in infants: the 2006 Brazilian National Demographic Health Survey

Estimating the herd immunity effect of rotavirus vaccine

The impact of rotavirus vaccination on emergency department visits and hospital admissions for acute diarrhea in children under 5 years

Contact Info

Product

Resources

About