Impact of ripening inhibitors on molecular transport of antimicrobial components from essential oil nanoemulsions

Ryu, Victor; Corradini, Maria G.; McClements, David Julian; McLandsborough, Lynne

doi:10.1016/j.jcis.2019.08.059

Cited by 35 publications

(17 citation statements)

References 35 publications

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“…The droplet size stability of CVNE can be attributed to the selection of the surfactants, which present the hydrophile–lipophile balance (HLB) value close to the required HLB of the oil phase and the presence of medium-chain triglycerides (MCTs) [ 23 , 26 , 27 ]. MCT was selected because it is a good Ostwald ripening inhibitor and contributes to the production of nanoemulsions with small droplet sizes [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Development, Characterization, and Immunomodulatory Evaluation of Carvacrol-loaded Nanoemulsion

et al. 2021

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Carvacrol (CV) is an essential oil with numerous therapeutic properties, including immunomodulatory activity. However, this effect has not been studied in nanoemulsion systems. The objective of this study was to develop an innovative carvacrol-loaded nanoemulsion (CVNE) for immunomodulatory action. The developed CVNE comprised of 5% w/w oily phase (medium chain triglycerides + CV), 2% w/w surfactants (Tween 80®/Span 80®), and 93% w/w water, and was produced by ultrasonication. Dynamic light scattering over 90 days was used to characterize CVNE. Cytotoxic activity and quantification of cytokines were evaluated in peripheral blood mononuclear cell (PBMC) culture supernatants. CVNE achieved a drug loading of 4.29 mg/mL, droplet size of 165.70 ± 0.46 nm, polydispersity index of 0.14 ± 0.03, zeta potential of −10.25 ± 0.52 mV, and good stability for 90 days. CVNE showed no cytotoxicity at concentrations up to 200 µM in PBMCs. CV diminished the production of IL-2 in the PBMC supernatant. However, CVNE reduced the levels of the pro-inflammatory cytokines IL-2, IL-17, and IFN-γ at 50 µM. In conclusion, a stable CVNE was produced, which improved the CV immunomodulatory activity in PBMCs.

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Section: Resultsmentioning

confidence: 99%

Development, Characterization, and Immunomodulatory Evaluation of Carvacrol-loaded Nanoemulsion

et al. 2021

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“…Nanoemulsion is a liquid–liquid dispersion system consisting of an aqueous phase, oil phase, and emulsifier with a droplet size of 10–300 nm dispersed in another phase. − Nanoemulsion is thermodynamically unstable but dynamically stable compared with microemulsions. As a new drug and pesticide delivery system, , nanoemulsions can not only increase the solubility of insoluble active ingredients but also load water-soluble active ingredients, improve their bioavailability, and play a role in targeting and slow release. − For agrochemicals, nanometer droplets can reduce rainwater erosion, prolong the control cycle, improve the utilization rate, prevent the degradation of active ingredients, and increase penetration, conduction, and target absorption to provide an effective, safe, and environment-friendly way for pesticide use. − Therefore, the research and development of nanoemulsions as a delivery system have become the current focus of the pesticide industry.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Pyriproxyfen-Loaded Nanoemulsion for Housefly Control: Improving Activity, Reducing Toxicity, and Protecting Ecological Environment

Feng

Chen

et al. 2021

ACS Sustainable Chem. Eng.

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Nanoemulsion provides an effective way for the efficient, safe, and environmentally friendly use for pesticides. In this study, the influence of the type, dosage of emulsifier, and emulsifying process on the formation and stability of nanoemulsion were investigated. On this basis, the optimal nanoemulsion formula loaded with pyriproxyfen was obtained. Pyriproxyfen (5%) and polyoxyethylene castor oil ether (6%; EL-20) were dissolved in hydrocarbon solvent (5%; S-100) with deionized water replenished to 100%. Compared with oil-in-water emulsion (EW) and emulsifiable concentrate (EC), the longest drying time ensured that the nanoemulsions had a more durable control effect. The pyriproxyfen-loaded nanoemulsions had a high pupation inhibition rate and 100% eclosion inhibition rate. In addition, at 7 and 14 days, the 50% lethal concentrations (LC 50 ) of pyriproxyfen-loaded nanoemulsions to Eisenia fetida were 1450.63 and 804.19 mg/kg, respectively, indicating their low acute toxicity to earthworms and environmental friendliness. Moreover, the pyriproxyfen-loaded nanoemulsions showed a low apoptosis rate (5.29%), whose value was considerably lower than that of EW (29.51%) and EC (9.45%), indicating a low toxicity to human hepatocyte L02 cells. This research facilitated the design and fabrication of nanoemulsions for water-insoluble pesticides to enhance the insecticidal activity, lower the cytotoxicity, and reduce environmental pollution of such chemicals.

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“…It is known that the E. citriodora essential oil (ECEO) has a wide spectrum of biological activities, including herbicidal [3,4] , antifungal [5] , insecticide [6] , antioxidant [7,8] , antimicrobial [9,10] properties. However, the storage of EOs is a critical matter due to their sensitivity to heat, humidity and air, being subject to hydrolysis, oxidation, dehydration and isomerization reactions [11][12][13] . Thus, the encapsulation of EOs is an important nanotechnological strategy to enable the use of such constituents, improving their physical-chemical stability and promoting protection against external factors [14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Polymeric nanoemulsions enriched with Eucalyptus citriodora essential oil

et al. 2020

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Eucalyptus citriodora oil has a well-known antimicrobial activity, however, its volatility limits its therapeutic applicability. Oil-in-water chitosan-based nanoemulsions have been prepared using a high-energy method in variable conditions in order to produce a stable formulation with an effective antimicrobial action. Physical-chemical characterizations and antimicrobial activity were performed. Results showed that the nanoemulsions with stability over 60 days and encapsulation efficiency higher than 90% were the ones with higher surfactant content. An optimal formulation was produced with the longer chain surfactant, which impacted in a particle size of 489.2±0.25nm and encapsulation efficiency of 92.5±0.17%. This formulation showed sustained release over 72h according to zero order kinetics, where the drug diffusion is lower than the respective dissolution release rate. The bactericidal action of the tested formulations showed an expressive inhibition rate against S. typhimurium (73%), with potential for an effective release system for antimicrobial control.

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Impact of ripening inhibitors on molecular transport of antimicrobial components from essential oil nanoemulsions

Cited by 35 publications

References 35 publications

Development, Characterization, and Immunomodulatory Evaluation of Carvacrol-loaded Nanoemulsion

Development, Characterization, and Immunomodulatory Evaluation of Carvacrol-loaded Nanoemulsion

Development and Characterization of Pyriproxyfen-Loaded Nanoemulsion for Housefly Control: Improving Activity, Reducing Toxicity, and Protecting Ecological Environment

Polymeric nanoemulsions enriched with Eucalyptus citriodora essential oil

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