Impact of renin–angiotensin–aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters

Abstract

Among the polymorphisms investigated, ACE D allele had the strongest association with abnormal myocardial perfusion.

Novel approaches for the management of coronary artery disease

“…However, we believe that a better understanding of CAD development can be achieved through the analysis of genetic information combined with functional imaging. Although Izadpanah et al did not find any association between the rs2713604 polymorphism and premature MI, we have reported the independent correlations (after adjustment for various factors, including CAD risk factors) of several gene polymorphisms with myocardial ischemia, based on stressrest myocardial single-photon emission computed tomography (SPECT) imaging [4][5][6]. In particular, polymorphisms of the following genes were investigated: factor V Leiden, factor II prothrombin, plasminogen activator inhibitor 1, β-fibrinogen, factor XIII, apolipoprotein E, angiotensin l-converting enzyme, angiotensinogen, angiotensin II type 1 receptor, angiotensin II type 2 receptor, and renin.…”

Premature CAD: Conventional Screening and Diagnostic Strategies May Not Capture the “Whole Picture”

“…7 In addition, evidence of a greater genetic CAD risk could be further evaluated using a functional imaging modality. 4 These techniques, such as myocardial SPECT, can depict subclinical features of CAD, providing diagnostic and prognostic evidence at an early stage of the disease. 4 To conclude, more efficient screening methods and diagnostic strategies regarding premature CAD may require the incorporation of genetic data in clinical practice.…”

“…4 These techniques, such as myocardial SPECT, can depict subclinical features of CAD, providing diagnostic and prognostic evidence at an early stage of the disease. 4 To conclude, more efficient screening methods and diagnostic strategies regarding premature CAD may require the incorporation of genetic data in clinical practice. The combination of functional imaging techniques and genetic analyses may contribute to an earlier diagnosis of CAD.…”

“…4 These techniques, such as myocardial SPECT, can depict subclinical features of CAD, providing diagnostic and prognostic evidence at an early stage of the disease. 4…”

Do we need diagnostic strategies enhanced with genetic information for ischemic heart disease?

“…9 It is important to note, however, that common SNPs, located on chromosome 9, were shown to lead to an increased risk level of IHD comparable to levels documented for conventional cardiovascular risk factors in population-based analyses (see the populationattributable risks (PARs) in Figure 1). 9 In the present issue of the Journal of Nuclear Cardiology, the association between gene polymorphisms and myocardial perfusion, investigated through SPECTderived parameters, has been addressed by Angelidis et al 10 The assessed polymorphisms were those of genes coding for the renin-angiotensin-aldosterone system (RAAS). The RAAS system is indeed known to have a significant impact on IHD development, as well as on several risk factors (hypertension, diabetes, and dyslipidemia).…”