Impact of Rehabilitation on Pulmonary Infection Risk Factors in Patients with Acute Cerebral Infarction

Wu, Ya-Fang; Han, Liyuan; Mao, Xinzhan; Huang, Xiao-Rui

doi:10.7727/wimj.2016.530

Cited by 1 publication

(3 citation statements)

References 14 publications

(30 reference statements)

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“…Barthel index. Eight RCTs [29,39,40,43,44,46,49,50] reported Barthel index differences between the trial and control groups. Heterogeneity analysis results (p = 0.01, I 2 = 64.08%) indicated heterogeneity among 8 RCTs, so the random effect model was used for analysis.…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

“…Adverse reaction. Six RCTs [32,34,40,46,47,50] reported adverse reactions. Heterogeneity analysis results (p = 0.47, I 2 = 0.00%) indicated heterogeneity among 8 RCTs.…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

“…The statistical result showed no signi cant difference in the incidence of adverse reactions between the two groups (RR = 0.59, 95%CI [0.26, 1.33], p = 0.21), so a descriptive discussion was taken. Two RCTs [34,40] showed that there were no severe adverse reactions in the trial group and the control group; four RCTs [32,46,47,50] reported speci c adverse reaction symptoms but returned to normal without special treatment. The details of adverse reactions are shown in Table 2.…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

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Therapeutic efficacy of Xingnaojing injection for ischemic stroke: A systematic review and meta-analysis of randomized controlled trials

Xiao

Xue

Huang

et al. 2023

Preprint

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Background Stroke is one of the leading causes of human disability and death, and ischemic stroke constitutes 69.6–70.8% of all strokes. Xingnaojing injection (XNJ) is used to treat stroke in China, but its specific mechanism is not completely clear. This meta-analysis evaluated the clinical efficacy and safety of XNJ for ischemic stroke treatment and showed that XNJ could inhibit the inflammatory response of stroke patients. Methods Nine databases were searched from inception to 20 July 2021, following the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) criteria for systematic reviews and meta-analyses. Two reviewers independently screened studies, extracted data of interest, and assessed the risk of bias. Meta-regression and subgroup analysis evaluated the heterogeneity and its impact on the results. Results In total, 24 separate RCTs, which were all conducted in China and published from 2008 to 2021, involved 2522 patients with ischemic stroke. XNJ combined with CT were better than CT alone in overall response rate (RR = 1.15, 95%CI [1.12, 1.19], p = 0.00), NIHSS score (WMD=-3.38, 95%CI [-4.35, -2.40], p = 0.00), Barthel index (WMD = 8.19, 95%CI [5.70, 10.68], p = 0.00), TNF-α (SMD=-2.75, 95%CI [-3.67, -1.84], p = 0.00), IL-6 (SMD=-2.56, 95%CI [-3.34, -1.70], p = 0.00), and CRP (SMD=-1.30, 95%CI [-1.58, -1.01], p = 0.00). Meta-analysis of safety showed that the data were not statistically significant (p = 0.21). For adverse events with low certainty evidence, safety needs further verification. Conclusions Based on the results, XNJ combined with CT likely improved clinical symptoms compared with CT alone. The mechanism may be related to the neuroprotective and anti-inflammatory effects. More high-quality, multicenter, and large-sample RCTs should be tested and verified in the future.

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Section: Meta-analysis Resultsmentioning

confidence: 99%

“…Adverse reaction. Six RCTs [32,34,40,46,47,50] reported adverse reactions. Heterogeneity analysis results (p = 0.47, I 2 = 0.00%) indicated heterogeneity among 8 RCTs.…”

Section: Meta-analysis Resultsmentioning

confidence: 99%

Section: Meta-analysis Resultsmentioning

confidence: 99%

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