Impact of Red Blood Cell Transfusion on Clinical Outcomes in Patients With Acute Myocardial Infarction

“…We identified 10 studies, [30][31][32][33][34][35][36][37][38][39] including 203 665 study participants, that met our inclusion and exclusion criteria. Only one study 31 was a randomized trial; the others were observational studies.…”

Section: Primary Outcomementioning

confidence: 99%

Association of Blood Transfusion With Increased Mortality in Myocardial Infarction

Chatterjee¹,

Wetterslev²,

Sharma³

et al. 2013

JAMA Intern Med

194

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“…Massive bleeding and blood transfusion are associated with increased morbidity, mortality, and costs [1][2][3][4]. This is not only true for the transfusion of packed red blood cells (PRBCs) but also of fresh frozen plasma (FFP) and platelets [5][6][7][8][9][10][11][12][13][14].…”

Section: General Medical and Economic Implications Of Massive Bleedinmentioning

confidence: 99%

Reduction of Fresh Frozen Plasma Requirements by Perioperative Point-of-Care Coagulation Management with Early Calculated Goal-Directed Therapy

Görlinger

Fries²,

Dirkmann³

et al. 2012

Transfus Med Hemother

190

107

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Background: Massive bleeding and transfusion of packed red blood cells (PRBC), fresh frozen plasma (FFP) and platelets are associated with increased morbidity, mortality and costs. Patients and Methods: We analysed the transfusion requirements after implementation of point-of-care (POC) coagulation management algorithms based on early, calculated, goal-directed therapy with fibrinogen concentrate and prothrombin complex concentrate (PCC) in different perioperative settings (trauma surgery, visceral and transplant surgery (VTS), cardiovascular surgery (CVS) and general and surgical intensive care medicine) at 3 different hospitals (AUVA Trauma Centre Salzburg, University Hospital Innsbruck and University Hospital Essen) in 2 different countries (Austria and Germany). Results: In all institutions, the implementation of POC coagulation management algorithms was associated with a reduction in the transfusion requirements for FFP by about 90% (Salzburg 94%, Innsbruck 88% and Essen 93%). Furthermore, PRBC transfusion was reduced by 8.4–62%. The incidence of intraoperative massive transfusion (≧10 U PRBC) could be more than halved in VTS and CVS (2.56 vs. 0.88%; p < 0.0001 and 2.50 vs. 1.06%; p = 0.0007, respectively). Platelet transfusion could be reduced by 21–72%, except in CVS where it increased by 115% due to a 5-fold increase in patients with dual antiplatelet therapy (2.7 vs. 13.7%; p < 0.0001). Conclusions: The implementation of perioperative POC coagulation management algorithms based on early, calculated, goaldirected therapy with fibrinogen concentrate and PCC is associated with a reduction in the transfusion requirements for FFP, PRBC and platelets as well as with a reduced incidence of massive transfusion. Thus, the limited blood resources can be used more efficiently.

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Impact of Red Blood Cell Transfusion on Clinical Outcomes in Patients With Acute Myocardial Infarction

Cited by 96 publications

References 27 publications

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction

2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction

Association of Blood Transfusion With Increased Mortality in Myocardial Infarction

Reduction of Fresh Frozen Plasma Requirements by Perioperative Point-of-Care Coagulation Management with Early Calculated Goal-Directed Therapy

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