Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva

Gasimli, Khayal; Straussner, Martina; Schmeil, Iryna; Karn, Thomas; Winkelmann, Ria; Becker, Sven; El‐Balat, Ahmed

doi:10.1007/s00404-018-4887-1

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…The effect of re‐excision of early‐stage vulvar SCC with positive or close surgical margins was examined in two studies. One was a comparison of the outcome of adjuvant radiotherapy with that of re‐excision, 24 and the other was an evaluation of the role of excision for treating grade III vulvar intraepithelial lesions 25 . Both studies failed to prove that adjuvant re‐excision produced better outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…One was a comparison of the outcome of adjuvant radiotherapy with that of re-excision, 24 and the other was an evaluation of the role of excision for treating grade III vulvar intraepithelial lesions. 25 Both studies failed to prove that adjuvant re-excision produced better outcomes. So far, adjuvant radiotherapy for patients with positive or close surgical margins has been reported retrospectively to reduce local recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Positive surgical margin is an independent predictor of overall survival of patients with vulvar squamous cell carcinoma

Nomura

Omi

Netsu

et al. 2021

J of Obstet and Gynaecol

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Aim: It is uncertain whether curative surgical treatment or a less radical surgery with adjuvant treatment should be provided to preserve function in patients with vulvar squamous cell carcinoma (SCC) that is adjacent to the urethra, anus, and vagina. The aim of this study was to investigate the surgical margin in patients with vulvar SCC with regard to local recurrence and overall survival. Methods: Thirty-four patients were identified as having a diagnosis of vulvar SCC without distant metastasis. They had been treated surgically with curative intent at the Cancer Institute Hospital. Clinical data were analyzed retrospectively. Results: Rates of 5-year local recurrence-free survival among patients with positive, <3-mm, <5-mm, <8-mm, and ≥8-mm surgical margins were 32%, 30.3%, 42.5%, 55.5%, and 73%, respectively. Rates of 5-year overall survival of patients with positive, <3-mm, <5-mm, <8-mm, and ≥8-mm surgical margins were 15.5%, 53.8%, 58.8%, 67.6%, and 83.3%, respectively. In the multivariable analysis, a tumor size of more than 2-cm (hazard ratio [HR] = 17.7, 95% confidence interval [CI] = 1.39-226) and a positive surgical margin (HR = 0.0092, 95% CI = 0.011-0.53) were risk factors for local recurrence, and a lymph node involvement (HR = 1.41, 95% CI = 0.31-6.43) and a positive surgical margin (HR = 0.0046, 95% CI = 0.011-0.53) were significant risk factors for overall mortality. Conclusions: To improve the prognosis, thorough resection with an adequate surgical margin is needed. But narrow surgical margin may be acceptable, particularly to preserve the function of adjacent organs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Positive surgical margin is an independent predictor of overall survival of patients with vulvar squamous cell carcinoma

Nomura

Omi

Netsu

et al. 2021

J of Obstet and Gynaecol

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show abstract

“…Normal tissue was used for comparative analysis of the normal tissue image adjacent to the tumor by microscopy. We know that the free margin of the tumor is very important for locoregional control of the vulvar tumor, because when compromised, it is usually indicative for performing a re-excision 24 . This suggests that SHG microscopy may be an important meteorology for safely distinguishing areas that are tumor-free margins from those with very early precursor lesions.…”

Section: Discussionmentioning

confidence: 99%

Study on collagen parameters in vulvar cancer and preneoplastic lesions by Second Harmonic Generation microscopy

Castor

Torres

Mello

et al. 2020

Sci Rep

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were plotted as the median and interquartile range (25th-75th). The Mann-Whitney nonparametric test was used to analyze numerical variables between two groups. The Kruskal-Wallis test was used to analyze numerical variables between three groups. Data analysis was performed using GraphPad Prism v 8.0 software (GraphPad Software, San Diego, CA). All comparisons were considered statistically significant at p < 0.05.

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A review of prognostic factors in squamous cell carcinoma of the vulva: Evidence from the last decade

Julia

Hoang

2021

Seminars in Diagnostic Pathology

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Impact of re-excision of residual adjacent vulvar intraepithelial neoplasia (VIN III) and histological tumour-free margin (hTFM) on survival in primary squamous cell carcinoma of vulva

Abstract: hTFM may be a potential prognostic indicator for DFS in vulvar cancer patients. Re-excision for residual adjacent VIN III could not be established as a prognostic factor for DFS after primary surgery in squamous cell cancer of vulva.

Cited by 4 publications

References 22 publications

Positive surgical margin is an independent predictor of overall survival of patients with vulvar squamous cell carcinoma

Positive surgical margin is an independent predictor of overall survival of patients with vulvar squamous cell carcinoma

Study on collagen parameters in vulvar cancer and preneoplastic lesions by Second Harmonic Generation microscopy

A review of prognostic factors in squamous cell carcinoma of the vulva: Evidence from the last decade

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