Impact of purified oat 1-3,1-4-β-d-glucan of different molecular weight on alleviation of inflammation parameters during gastritis

Suchecka, Dominika; Błaszczyk, Katarzyna; Harasym, Joanna; Gudej, Sylwia; Wilczak, Jacek; Gromadzka-Ostrowska, Joanna

doi:10.1016/j.jff.2016.10.028

Cited by 21 publications

(14 citation statements)

References 42 publications

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“…Current report strongly demonstrates that optimal dosage of β-glucan derived from Agrobacterium sp. ZX09 was 100 mg/kg of diet for fattening pigs, while the optimal doses of β-glucan previously applied were various and their sources were mainly obtained from cell wall of Saccha-romycetes cerevisiae (Shao et al., 2016, Tian et al., 2016) and purified from oat (Suchecka et al., 2016, Suchecka et al., 2017). Beta-glucan purity obtained from Agrobacterium sp.…”

Section: Discussionmentioning

confidence: 99%

Dietary β-glucan supplementation improves growth performance, carcass traits and meat quality of finishing pigs

et al. 2019

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This experiment was conducted to investigate growth performance, carcass traits and meat quality of finishing pigs with dietary β-glucan supplementation. A total of 96 healthy pigs (Duroc × Landrace × Yorkshire; initial average BW = 25 kg) were randomly allocated into 4 dietary treatments with 6 replicates per treatment and 4 pigs per replicate. The control group was fed a basal diet, and the experimental diets were supplemented with 50, 100 and 200 mg/kg Agrobacterium sp. ZX09 β-glucan, respectively. The experiment lasted 103 d. The basal diet supplemented with 100 mg/kg β-glucan significantly increased average daily gain and feed conversion ratio, probably due to the improved digestibility of dry matter, gross energy and crude protein (P < 0.05). Beta-glucan supplementation from 100 to 200 mg/kg of diet significantly increased carcass length (P < 0.05). The basal diet supplemented with 100 mg/kg β-glucan supplementation also significantly (P < 0.05) increased muscle pH, reduced drip losses and increased a∗ values. The basal diet supplemented with 100 mg/kg β-glucan increased the content of intramuscular fat and changed the proportion of saturated fatty acid and unsaturated fatty acid, thereby improved the flavor of meat. In conclusion, the basal diet supplemented with 100 mg/kg Agrobacterium sp. ZX09 β-glucan improves growth performance, nutrient digestibility, carcass length, and pork quality of finishing pigs.

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Section: Discussionmentioning

confidence: 99%

Dietary β-glucan supplementation improves growth performance, carcass traits and meat quality of finishing pigs

et al. 2019

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“…Our results are similar to the research by Suchecka et al, but their sources (Agrobacterium sp. ZX09 vs. oat) are different [22].…”

Section: Discussionmentioning

confidence: 99%

Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Luo

Chen

Mao

et al. 2019

Animals

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Simple SummaryBeta-glucan is currently under consideration as an alternative to in-feed antibiotics for the sustainable pig production industry in China. Modulating intestinal function by β-glucan treatment in young pigs is one potential way of decreasing disease susceptibility and presumably increasing growth performance. In the present study, as a newly developed commercial product, β-glucans have proved to modulate gut function, and have improved growth performance in lipopolysaccharide (LPS)-challenged piglets. The present study aimed to determine the mechanisms involved inβ-glucan of low and high molecular weight mediated growth alterations in weaned piglets. The results confirmed that β-glucans isolated from Agrobacterium sp. ZX09 could improve growth performance in weaned piglets and they showed intestinal modulatory properties via different mechanisms in regulating the mucosal barrier function and microbial populations between two different molecular weight β-glucans.AbstractThis study investigated β-glucan derived from Agrobacterium sp. ZX09 with high (2000 kDa) and low (300 kDa) molecular weight (MW) to compare their effects on growth performance and gut function in LPS-induced weaned piglets. Changes in jejunal morphology, mucosal barrier function, microbial populations, and fermentation in the piglets were determined. Data showed that β-glucan prevented body weight loss in LPS challenged piglets. Supplementation with both β-glucan fractions improved jejunal morphology. Compared to low MW, β-glucan of high MW generally up-regulated transcripts of ZO-1, MUC1, and MUC2 in jejunal mucosa to a lesser extent. Mucosal D-lactate, diamine oxidase, and anti-oxidation index were effectively resumed in β-glucan treatment. Both β-glucan diets provoked the emergence of a balanced microbiota and a richer concentration of volatile fatty acids in the colon. The richest community of bifidobacterium and concentration of butyrate emerged after feeding β-glucan with high MW. Results suggested that the effect of Agrobacterium sp. ZX09 β-glucans on the gut-modulatory function is largely linked to their MW. Low MW β-glucan mainly improved the mucosal barrier function in the jejunum, while high MW β-glucan had profound effects on the microbial community and fermentation in the hindgut of piglets.

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“…Several studies have concluded that not only the high molecular mass fraction of purified oat β-glucan reveals bioactivity, but also the low molar mass fraction of this polymer triggers other metabolic pathways resulting in activities like antioxidative, anti-inflammatory properties in gastritis and enteritis, pro-apoptotic vs. human melanoma, antitumor activities vs. cancer cells: Me45, A431, and normal HaCaT and murine macrophages P388/D1, hepato- and gastroprotective activity, inflammation alleviation in gastritis, antitumor activities in human epithelial cancer or regulation of genes connected with the immune response [5,6,7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Proteinaceous Residue Removal from Oat β-Glucan Extracts Obtained by Alkaline Water Extraction

et al. 2019

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Background: Wet methods of 1-3, 1-4 -β-D-glucan isolation from cereals differ mainly in the type of grain fraction used as raw material, the solid-liquid ratio of β-glucan in raw material vs. solvent used, and the type of aqueous solvent modification (alkali, neutral or acidic). All these factors impact the characterization of the residues finally found in extracts. Oat bran is a rich source of globulin fraction which can be transferred into the extracts, especially when a high pH is employed. Methods: A multi-stage (enzymatic and acidic) purification procedure was performed to remove the residues, especially starch and protein, from β-glucan isolates from oat of different molar mass. Pancreatin, thermostable α-amylase, amyloglucosidase, and papain were used for consecutive residue removal. Three levels of low pH = 4.5, 3.5 and 3.0 were also tested for effective protein precipitation. Results: The starch hydrolysis and liquefaction significantly facilitate the proteinaceous matter removal although papain usage showed an intensive unfavorable impact on β-glucan molar mass. Soluble protein content was significantly decreased after pancreatin and α-amylase treatment, while the significant reduction of amine nitrogen was noted after complete starch hydrolysis and a second acidification step. Conclusions: A complex procedure employing different enzymes is needed to successfully reduce the possibly bioactive residues in isolated oat β-glucan fractions.

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Impact of purified oat 1-3,1-4-β-d-glucan of different molecular weight on alleviation of inflammation parameters during gastritis

Cited by 21 publications

References 42 publications

Dietary β-glucan supplementation improves growth performance, carcass traits and meat quality of finishing pigs

Dietary β-glucan supplementation improves growth performance, carcass traits and meat quality of finishing pigs

Purified β-glucans of Different Molecular Weights Enhance Growth Performance of LPS-challenged Piglets via Improved Gut Barrier Function and Microbiota

Proteinaceous Residue Removal from Oat β-Glucan Extracts Obtained by Alkaline Water Extraction

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