Impact of prevalent and incident vertebral fractures on utility: results from a patient-based and a population-based sample

Schoor, Natasja M. van; Ewing, Susan K.; O'Neill, Terence W; Smit, Jan; Lips, Paul

doi:10.1007/s11136-007-9287-0

Cited by 13 publications

(6 citation statements)

References 26 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In regard to HSV, in their prospective study, Strom et al reported lower mean EQ-5D-UK HSV for vertebral fracture and similar mean HSV for hip and wrist fracture groups at 1 year [54]. EQ-5D-UK HSV published from the European MORE and EPOS studies were slightly lower than those in our study [55, 56]. Hagino et al reported similar mean EQ-5D HSV at 1-year post fracture to our mean EQ-5D HSV by fracture type using Japanese preference weights [57].…”

Section: Discussioncontrasting

confidence: 55%

Predicting EQ-5D-US and SF-6D societal health state values from the Osteoporosis Assessment Questionnaire

2011

View full text Add to dashboard Cite

Summary Linear regression was applied to data from 275 persons with osteoporosis-related fracture to estimate EQ-5D-US and SF-6D health state values from the Osteoporosis Assessment Questionnaire. The models explained 56% and 58% of the variance in scores, respectively, and root mean square error values (0.096 and 0.085) indicated adequate prediction for use when actual values are unavailable. Introduction This study was conducted to provide models that predict EQ-5D-US and SF-6D societal health state values from the Osteoporosis Assessment Questionnaire (OPAQ). Methods OPAQ, EQ-5D, and SF-6D data from individuals at two centers with prior osteoporosis-related fracture were used. Fractures were classified by type as hip/hip-like, spine/spine-like, or wrist/wrist-like. Spearman rank correlations between preference-based system (EQ-5D and SF-6D) dimensions and OPAQ subscales were estimated. Linear regression was used to estimate preference-based system health state values based on OPAQ subscales. We assessed models including age, sex, and fracture type and chose the model with the best performance based on the root mean square error (RMSE) estimate. Results Among the 275 participants (198 women), with mean age of 68 years (range 50–94), the distribution of fracture types included 10% hip/5% hip-like, 18% spine/11% spine-like, and 24% wrist/18% wrist-like. The final regression model for EQ-5D-US included three OPAQ attributes (physical function, emotional status, and symptoms), predicted 56% of the variance in EQ-5D-US scores, and had a RMSE of 0.096. The final model for SF-6D, which included all four OPAQ dimensions, predicted 58% of the variance in SF-6D scores and had a RMSE of 0.085. Conclusions Two models were developed to estimate EQ-5D-US and SF-6D health state values from OPAQ and demonstrated adequate prediction for use when actual values are not available.

show abstract

Section: Discussioncontrasting

confidence: 55%

Predicting EQ-5D-US and SF-6D societal health state values from the Osteoporosis Assessment Questionnaire

2011

View full text Add to dashboard Cite

show abstract

“…As reported earlier, part of this finding can be explained by the fact that prevalent vertebral compression fractures worsen back pain [15,17,33,40,41,43,44] and QoL [23,35,46,47,51]. The number and severity of the prevalent fracture were especially related to the outcomes [15,35,43,47,51]. The most likely explanation for the worsening negative effect of a previous fracture is that the patients in this study who had a previous fracture(s) already were more disabled and had a lower QoL at the time when the subsequent acute fracture occurred.…”

Section: Discussionmentioning

confidence: 54%

Previous vertebral compression fractures add to the deterioration of the disability and quality of life after an acute compression fracture

2009

View full text Add to dashboard Cite

Prevalent vertebral compression fracture(s) have been reported as having a negative impact on pain, disability, and quality of life. But no study has evaluated the effect of previous fracture on the course of acute compression fractures. The aim of the present study was to compare the natural course of the acute compression fracture in patients with (n = 51) and without (n = 56) previous vertebral compression fracture(s). The study is a retrospective analysis of a prospective cohort followed with postal questionnaires during a 12-month period after an acute fracture event. Eligible patients were those over 40 years of age, who were admitted to the emergency unit because of back pain and had an X-ray confirmed acute vertebral body fracture. A total of 107 patients were included in the study. The pain, disability (von Korff pain and disability scores), ADL (Hannover ADL score), and quality of life (QoL) (EQ-5D) were measured after 3 weeks, and 3, 6, and 12 months. The X-rays from the first visit to the emergency unit were evaluated. The difference of the scores between the groups with and without previous fracture was statistically significant (P \ 0.05) at 3 weeks, 6 and 12 months for von Korff disability score, at all occasions for EQ-5D and at 3-12 months for Hannover ADL score, but only at 12 months for the von Korff pain intensity score. In both the groups all scores had improved in a statistically significant way at 3 months. The number of previous fractures was related to all the outcome scores in a statistically significant way (P \ 0.05) except von Korff pain intensity score at 3 weeks and 3 months and von Korff disability score at 3 months. In conclusion, disability, ADL, and QoL scores, but not pain intensity score, were significantly worse in the patients with previous fracture from the fracture episode through the first 12 months. However, the improvements during the followup year seen in both groups were of a similar magnitude. The presence or absence of a previous fracture in an acutely fractured patient will influence the prognosis and thus possibly also the indications for treatments.

show abstract

“…Of the ICUROS results, the Swedish values were thought to be the most appropriate because they were based on the largest sample of the various country-specific cohorts and they were expected to provide a good estimator of UK HRQoL values, as northern European countries have been shown to have similar values. 231 Values from eight papers 207,[224][225][226][227][228][229][230] reporting outcomes from five distinct studies were therefore compared.…”

Section: Assessment Of Cost-effectivenessmentioning

confidence: 99%

A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures

Davis

James

Sanderson

et al. 2016

Health Technol Assess

View full text Add to dashboard Cite

show abstract

Impact of prevalent and incident vertebral fractures on utility: results from a patient-based and a population-based sample

Cited by 13 publications

References 26 publications

Predicting EQ-5D-US and SF-6D societal health state values from the Osteoporosis Assessment Questionnaire

Predicting EQ-5D-US and SF-6D societal health state values from the Osteoporosis Assessment Questionnaire

Previous vertebral compression fractures add to the deterioration of the disability and quality of life after an acute compression fracture

A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures

Contact Info

Product

Resources

About