Impact of Pretransplant Infections on Clinical Course in Liver Transplant Recipients

Kim, Y.J.; Yoon, Jihyun; Kim, S.I.; Choi, Ho Joong; Choi, Jung‐Hyun; Yoon, Seung Kew; You, Yong‐Ouk; Kim, D.-G.

doi:10.1016/j.transproceed.2018.01.036

Cited by 22 publications

(27 citation statements)

References 11 publications

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“…Pneumonia, SBP, and UTI were the most common pre‐transplant infections. Other studies have demonstrated a similar predominance of these infections among patients with cirrhosis . Forty of 128 patients (23%) developed an infection within 30 days of transplant, fewer than would be expected based on data from the 1980s and 1990s, when up to 40% of LT recipients developed an infection within 1 month of transplant .…”

Section: Discussionmentioning

confidence: 69%

“…The link between pre‐transplant infections and post‐transplant infections is not consistent in all prior studies . A study of 357 LDLT recipients in South Korea showed the pre‐transplant infection is associated with increased risk of post‐transplant infection and bacteremia . Another study of 20 LDLT recipients in Japan showed increased risk of infection within the first week after transplant, but this association dissipated by 1 month, and there was no relationship between pathogens in each period .…”

Section: Discussionmentioning

confidence: 91%

“…Infections in the pre‐LT population can have devastating impact on immediate well‐being and candidacy for transplantation. While some studies have shown that pre‐transplant infections have no impact on post‐transplant mortality or graft function, 42% of patients who develop bacterial infection while waiting for LT are de‐listed or die prior to transplant …”

Section: Introductionmentioning

confidence: 99%

“…Nosocomial bacterial infections are the most common infectious source in the early post‐transplant period, often occurring within the 1 month after transplant . Incidence of bacterial infection in the first 3 months after LT has been reported to be between 14% and 75%, with considerable variation by transplant center . Surgical site infection (SSI) is the most common bacterial infection after liver transplant and can occur in the form of a superficial incisional infection or, more commonly, as a deep infection (ie, cholangitis or abdominal abscess) as a consequence of manipulation of the biliary system and hepatic vasculature .…”

Section: Introductionmentioning

confidence: 99%

“…While the risk factors and outcomes of both pre‐ and post‐transplant infections are well defined, their relationship is less established. Whether pre‐transplant infection is a risk factor for post‐transplant infection remains unclear, as data previous studies addressing this issue have shown mixed results . We performed a single‐center retrospective cohort study to determine the relationship between pre‐transplant infections and post‐transplant infections among adult liver transplant recipients.…”

Section: Introductionmentioning

confidence: 99%

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Pre‐ and post‐transplant bacterial infections in liver transplant recipients

Heldman

Ngo²,

Dorschner

et al. 2019

Transplant Infectious Dis

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Background Early (<1 month) bacterial infection after liver transplant is a major cause of morbidity and mortality among liver transplant recipients. We investigated the impact of pre‐transplant bacterial infection on early post‐transplant bacterial infection incidence and outcomes. Methods A retrospective cohort study identified all patients who underwent liver transplantation between January 1, 2011, and December 31, 2012, at a single tertiary center in the United States. Infections occurring within the 30 days prior to transplant and within the 30 following transplant were identified. Information regarding pre‐transplant morbidity and post‐transplant outcomes was collected. Results One‐hundred seventy‐four patients were included in the study. Forty patients (23%) experienced a total of 50 pre‐transplant infections. Fifty‐two (30%) developed a total of 62 post‐transplant infections. Patients with a pre‐transplant infection were more likely to develop a post‐transplant infection compared to patients without a pre‐transplant infection (48% [19 of 40] vs. 25% [33 of 134], respectively, P = .006). Patients with a pre‐transplant infection had a longer mean post‐transplant length of stay compared to those without a pre‐transplant infection (16.3 days vs. 10.4 days, respectively, P < .001), but survival at 30 days was similar in both groups (95% [38 of 40] vs. 97% [130 of 134, respectively, P = .56). Conclusions Among liver transplant recipients, pre‐transplant infection is an important risk factor for early post‐transplant bacterial infections. Pre‐transplant infection is associated with increased early morbidity but not mortality after transplant.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%