Impact of pretherapy body mass index on prognosis of nasopharyngeal carcinoma

Pretreatment body mass index and head and neck cancer outcome: A review of the literature

“…Huang et al reported that obese patients had a worse OS than overweight patients, since more patients died of obesity-related [17] found lower RR for recurrence free survival (RFS) in both overweight and obese patients and the association remained significant after multivariate analysis ( Table 3). The studies of Arthur et al [18], Pai et al [20] and McRackan et al [14] found that overweight and obese HNSCC patients had a significantly better overall survival than patients in lower BMI categories after multivariate analysis (Table 2).…”

“…Seven studies [12,[15][16][17][18][19]22], three with only NPC patients, two with only HNSCC patients and two with all HNC subsites, together reported 2092 overweight and 689 obese patients in their population at baseline, the other six studies did not report data on numbers of patients in different BMI categories. Seven of the included studies also distinguished between overweight and obese patients and their survival and recurrence rates [12,[15][16][17]19,21,22]. There were differences in duration of follow-up with medians ranging from 2.2 years [14] to 8.6 years [20] (Table 1).…”

“…The studies of Huang et al [15] and Hu et al [17] found that overweight and obese NPC patients had a significantly higher OS-rate than normal weight patients (Table 2). Huang et al reported that obese patients had a worse OS than overweight patients, since more patients died of obesity-related [17] found lower RR for recurrence free survival (RFS) in both overweight and obese patients and the association remained significant after multivariate analysis ( Table 3).…”

“…Of the thirteen included studies in this review, six were prospective cohort studies [12,15,16,18,21,23] and seven retrospective cohort studies [13,14,17,19,20,22,24]. Other study characteristics such as study population, BMI assessment, comparison between BMI groups, analysis, outcome and time of follow-up are described in Table 1.…”

“…Most studies [12,[14][15][16][17][18][19][20][21][22][23][24] corrected for other variables for overall survival or mortality, such as age [14][15][16][17][18][19][20][21][22],cancer stage [14][15][16][17][18][19][20], smoking status [12,14,16,18,19,22], alcohol consumption [12,14,16,21,22] and tumor site [14,18] (Tables 2, 3 and 4). In most studies, BMI remained significantly associated with outcome.…”