Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea

Lamichhane, Dirga Kumar; Leem, Jong Han; Kim, Hwan Cheol; Lee, Ji Young; Park, Myung‐Sook; Jung, Dal Young; Ko, Jeong‐Hyeon; Ha, Mina; Kim, Yangho; Hong, Yun Chul; Ha, Eun Hee

doi:10.1017/s1368980016000550

Cited by 27 publications

(11 citation statements)

References 59 publications

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“…The discrepancy between studies may be due to different naphthalene exposure levels. The median concentration of urinary 2-OH NAP (6.34 μg/g) in the present study was higher than that observed in the study by Lamichhane et al (9.96 ng/g) [18] and Herbstman et al (3.11 μg/g) [36]. Jing JQ et al [22] showed that the highest emission load among 16 PAHs was naphthalene in Taiyuan, with a 39.18% contribution rate.…”

Section: Discussioncontrasting

confidence: 77%

“…Polanska et al [16] detected a link between the sum of hydroxyphenanthrene levels and the higher cephalization index (CI). The relationship between 1-hydroxypyrene (1-OH PYR) and birth outcomes has also been investigated in previous studies [9, 17, 18]. However, the association between naphthalene exposure and birth outcomes has rarely been tested in epidemiological studies.…”

Section: Introductionmentioning

confidence: 99%

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Maternal urinary 2-hydroxynaphthalene and birth outcomes in Taiyuan, China

Nie

Cheng

et al. 2018

Environ Health

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BackgroundNaphthalene is the simplest polycyclic aromatic hydrocarbon (PAH). It is easily emitted into the atmosphere, posing a significant risk to human health. However, limited studies have described the impact of naphthalene exposure on birth outcomes. In this study, we investigated the association between the maternal urinary metabolites of naphthalene, 2-hydroxynaphthalene (2-OH NAP), and birth outcomes.MethodIn the present study, four urinary PAH metabolites were measured in 263 pregnant women during late pregnancy. Multiple linear regression analysis was used to analyze the relationship between the concentrations of 2-OH NAP and birth outcomes, and restricted cubic spline models were further used to examine the shapes of the dose-response association.ResultGeneral linear models showed that prenatal urinary 2-OH NAP was associated with lower birth weight (BW) (− 4.38% for the high vs. low exposure group of 2-OH NAP; p for trend = 0.049) and higher cephalization index (CI) (4.30% for the high vs. low exposure group of 2-OH NAP; p for trend = 0.038). These associations were linear and significant when 2-OH NAP was modeled as a continuous variable in restricted cubic spline models (P linear = 0.0293 for 2-OH NAP and BW; P linear = 0.0326 for 2-OH NAP and CI). Multiple linear regression data indicated that each 1 ln-unit increase in 2-OH NAP was significantly associated with a 2.09 g/cm increase in the CI. The associations among 2-OH NAP, BW, and CI were also observed in a subset of participants residing close to arterial traffic.ConclusionOur data indicated that prenatal exposure to naphthalene had an adverse effect on fetal birth outcomes, especially the brain development index. Reduced exposure to naphthalene may improve newborn health outcomes. In Taiyuan, naphthalene may result from traffic pollution.Electronic supplementary materialThe online version of this article (10.1186/s12940-018-0436-4) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Maternal urinary 2-hydroxynaphthalene and birth outcomes in Taiyuan, China

Nie

Cheng

et al. 2018

Environ Health

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“…Several studies have shown that maternal dietary (215) (180) and airborne PAH (215) exposure as well as PAH-DNA adduct levels in newborns (314) (315) are associated with reduced birth weight. Conversely, prenatal and early exposure to PAHs is positively associated with increased BMI, obesity, and waist circumference in childhood (197) (335) (346).…”

Section: Associations Between Pop Exposures and The Development Of Obmentioning

confidence: 99%

Adipose Tissue as a Site of Toxin Accumulation

Jackson

Shoemaker

Larian

et al. 2017

Comprehensive Physiology

136

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We examine the role of adipose tissue, typically considered an energy storage site, as a potential site of toxicant accumulation. Although the production of most persistent organic pollutants (POPs) was banned years ago, these toxicants persist in the environment due to their resistance to biodegradation and widespread distribution in various environmental forms (e.g., vapor, sediment, water). As a result, human exposure to these toxicants is inevitable. Largely due to their lipophilicity, POPs bioaccumulate in adipose tissue, resulting in greater body burdens of these environmental toxicants with obesity. POPs of major concern include polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins and furans (PCDDs/PCDFs), and polybrominated biphenyls and diphenyl ethers (PBBs/PBDEs), among other organic compounds. In this review, we 1) highlight the physical characteristics of toxicants that enable them to partition into and remain stored in adipose tissue, 2) discuss the specific mechanisms of action by which these toxicants act to influence adipocyte function, and 3) review associations between POP exposures and the development of obesity and diabetes. An area of controversy relates to the relative potential beneficial versus hazardous health effects of toxicant sequestration in adipose tissue.

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“…It can affect the intelligence of children as well as causing respiratory problems, since they are more sensitive to such contaminants than adults (Edwards et al, 2010;Lamichhane et al, 2016;Song et al, 2013). There are many studies on the exposure of pregnant women, such as heavy metal exposure (Kim et al, 2011;Pola nska et al, 2014), pesticide exposure (Yu et al, 2016;Wang, Chen, et al, 2017), mycotoxin exposure (Lei et al, 2013;Sarkanj et al, 2013), passive smoking exposure (Baheiraei et al, 2012), and so on.…”

Section: Introductionmentioning

confidence: 99%

Polycyclic aromatic hydrocarbons residues and the carcinogenic risk assessment to pregnant women in Nantong, China using QuEChERS method and HPLC—A pilot case study

Guo

Shi

Gu³

et al. 2021

Biomedical Chromatography

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A high-performance liquid chromatographic method with a modified QuEChERS extraction for the determination of polycyclic aromatic hydrocarbons (PAHs) in blood serum was developed to investigate the internal exposure level and the carcinogentic toxicity contribution rate of PAHs for pregnant women in Nantong, China. Venous blood (n = 48) was collected in the local hospital and the internal exposure level of 16 PAHs and the contribution rate of carcinogenicity to pregnant women were analyzed. Among all of the detected PAHs, the detection rate of pyrene (77.08%) was the highest, followed by naphthalene (64.58%) and benzo[a]anthracene (BaA, 45.83%). The carcinogenicity contribution rate of BaA (37.37%) was the highest, followed by fluorene (32.96%) and acenaphthylene (22.01%). The results showed that many kinds of carcinogenic PAHs can be detected in the serum of pregnant women in Nantong city, among which BaA should be paid most attention because of its high internal exposure level and carcinogenic risk. Meanwhile, the origins of general PAHs in serum samples were analyzed using the characteristic ratio analysis method. The PAH pollution level of air samples (n = 42) during the collection time of blood samples was also analyzed to compare the possible correlations between the two different results.

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Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea

Cited by 27 publications

References 59 publications

Maternal urinary 2-hydroxynaphthalene and birth outcomes in Taiyuan, China

Maternal urinary 2-hydroxynaphthalene and birth outcomes in Taiyuan, China

Adipose Tissue as a Site of Toxin Accumulation

Polycyclic aromatic hydrocarbons residues and the carcinogenic risk assessment to pregnant women in Nantong, China using QuEChERS method and HPLC—A pilot case study

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