Impact of preconditioned diabetic stem cells and photobiomodulation on quantity and degranulation of mast cells in a delayed healing wound simulation in type one diabetic rats

Ahmadi, Houssein; Bayat, Mohammad; Amini, Abdollah; Mostafavinia, Atarodalsadat; Ebrahimpour-Malekshah, Roohollah; Gazor, Rouhollah; Asadi, Robabeh; Gachkar, Latif; Rezaei, Fatemehalsadat; Shafikhani, Sasha H.; Ghoreishi, Seyed Kamran; Chien, Sufan

doi:10.1007/s10103-021-03408-9

Cited by 15 publications

(32 citation statements)

References 45 publications

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“…Even though all nine studies reported the use of red and/or near‐infrared wavelengths, PBM protocols were rather diversified (Tables 2 and 3). Moreover, all of them reported that PBM combined with SCs at pre or postexposure ameliorates cutaneous repair by different mechanisms depending on the skin wound model (19–27) (Tables 2 and 3).…”

Section: Resultsmentioning

confidence: 99%

Could Light‐Based Technologies Improve Stem Cell Therapy for Skin Wounds? A Systematic Review and Meta‐Analysis of Preclinical Studies^†

Yoshimura

Cabral

Sellera

et al. 2022

Photochem & Photobiology

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Several diseases or conditions cause dermatological disorders that hinder the process of skin repair. The search for novel technologies has inspired the combination of stem cell (SC) and light-based therapies to ameliorate skin wound repair. Herein, we systematically revised the impact of photobiomodulation therapy (PBM) combined with SCs in animal models of skin wounds and quantitatively evaluated this effect through a meta-analysis. For inclusion, SCs should be irradiated in vitro or in vivo, before or after being implanted in animals, respectively. The search resulted in nine eligible articles, which were assessed for risk of bias. For the metaanalysis, studies were included only when PBM was applied in vivo, five regarding wound closure, and three to wound strength. Overall, a positive influence of SC + PBM on wound closure (mean difference: 9.69; 95% CI: 5.78-13.61, P < 0.00001) and strength (standardized mean difference: 1.7, 95% CI: 0.68-2.72, P = 0.001) was detected, although studies have shown moderate to high heterogeneity and a lack of information regarding some bias domains. Altogether, PBM seems to be an enabling technology able to be applied postimplantation of SCs for cutaneous regeneration. Our findings may guide future laboratory and clinical studies in hopes of offering wound care patients a better quality of life.

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Section: Resultsmentioning

confidence: 99%

Could Light‐Based Technologies Improve Stem Cell Therapy for Skin Wounds? A Systematic Review and Meta‐Analysis of Preclinical Studies^†

Yoshimura

Cabral

Sellera

et al. 2022

Photochem & Photobiology

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“…To further understand whether the function of ASCs is affected by the diabetic environment in immune-modulating, histological observation is also conducted in several studies using rat ASCs ( 37 , 45 , 47 , 50 , 51 ) and several studies using human ASCs ( 32 , 46 ). It is shown that utilization of either diabetic or healthy ASCs on diabetic wounds reduces inflammatory cells infiltration.…”

Section: Mechanisms Of Ascs To Promote Diabetic Wound Healingmentioning

confidence: 99%

“…This suggests that non-diabetic ASCs can significantly accelerate the immune process more than diabetic wounds. In a study conducted by Ahmadi et.al, photo-biomodulation is introduced to diabetic ASCs under the condition of infectious diabetic wounds ( 50 ). This method significantly accelerated the switch from the inflammatory phase to the post-inflammatory phase within the use of diabetic ASCs.…”

Section: Mechanisms Of Ascs To Promote Diabetic Wound Healingmentioning

confidence: 99%

Adipose-Derived Stem Cells for the Treatment of Diabetic Wound: From Basic Study to Clinical Application

et al. 2022

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Diabetic wounds significantly affect the life quality of patients and may cause amputation and mortality if poorly managed. Recently, a wide range of cell-based methods has emerged as novel therapeutic methods in treating diabetic wounds. Adipose-derived stem cells (ASCs) are considered to have the potential for widespread clinical application of diabetic wounds treatment in the future. This review summarized the mechanisms of ASCs to promote diabetic wound healing, including the promotion of immunomodulation, neovascularization, and fibro synthesis. We also review the current progress and limitations of clinical studies using ASCs to intervene in diabetic wound healing. New methods of ASC delivery have been raised in recent years to provide a standardized and convenient use of ASCs.

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“…12,37 The signal between the nucleus and mitochondria affects many cellular activities in both pathological and normal conditions, 35,38 although the optimal result of PBM is seen in stressed cells more than it is seen in healthy cells. 39,40 It has already been proven that ROS overproduction occurs through the dysfunction of mitochondria in pathologic conditions. 41 The PBM appears to be the initial stage of the recuperation of oxidative stress since the mitochondria are the primary site for interactions between red/NIR light cells.…”

Section: Mechanism Of Photobiomodulation On Atp Ca and Rosmentioning

confidence: 99%

Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review

et al. 2022

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About 50% of infertility problems are related to male factors and reduced sperm motility. The important factor that affects the structure and function of sperm is reactive oxygen species (ROS), and over-concentration of ROS reduces the quality and motility of sperm. Photobiomodulation therapy (PBMT) using red to near-infrared (NIR) light is useful in oxidative stress restoration. It plays a therapeutic role in disorders such as asthenospermia, oligospermia cases, and cryopreserved sperm. It also enhances the metabolic capacity of sperm and increases the low-level and non-harmful intracellular content of Ca2+, nitric oxide (NO), and ROS in the stressed cells. Likewise, it modulates survival intracellular pathways and maintains the motility, viability, DNA, and acrosome integrity of sperm. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of semen PBMT.

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Impact of preconditioned diabetic stem cells and photobiomodulation on quantity and degranulation of mast cells in a delayed healing wound simulation in type one diabetic rats

Cited by 15 publications

References 45 publications

Could Light‐Based Technologies Improve Stem Cell Therapy for Skin Wounds? A Systematic Review and Meta‐Analysis of Preclinical Studies^†

Could Light‐Based Technologies Improve Stem Cell Therapy for Skin Wounds? A Systematic Review and Meta‐Analysis of Preclinical Studies^†

Adipose-Derived Stem Cells for the Treatment of Diabetic Wound: From Basic Study to Clinical Application

Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review

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Impact of preconditioned diabetic stem cells and photobiomodulation on quantity and degranulation of mast cells in a delayed healing wound simulation in type one diabetic rats

Cited by 15 publications

References 45 publications

Could Light‐Based Technologies Improve Stem Cell Therapy for Skin Wounds? A Systematic Review and Meta‐Analysis of Preclinical Studies†

Could Light‐Based Technologies Improve Stem Cell Therapy for Skin Wounds? A Systematic Review and Meta‐Analysis of Preclinical Studies†

Adipose-Derived Stem Cells for the Treatment of Diabetic Wound: From Basic Study to Clinical Application

Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review

Contact Info

Product

Resources

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Could Light‐Based Technologies Improve Stem Cell Therapy for Skin Wounds? A Systematic Review and Meta‐Analysis of Preclinical Studies^†

Could Light‐Based Technologies Improve Stem Cell Therapy for Skin Wounds? A Systematic Review and Meta‐Analysis of Preclinical Studies^†