Impact of polymorphisms of the DNA repair gene XRCC1 and their role in the risk of prostate cancer

Hui, Zhu; Jiu, Tao; Wang, Dong

doi:10.12669/pjms.312.6653

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…Table 1 showed the characteristics of all the eligible studies and genotype frequency distributions of twelve polymorphisms in five XRCC genes ( XRCC1 -rs915927, XRCC1 -rs25489, XRCC1 -rs25487, XRCC1 -rs1799782, XRCC1 -rs3213245, XRCC2 -rs3218536, XRCC3 -rs1799796, XRCC3 -rs861539, XRCC4 -rs6869366, XRCC4 -rs28360071, XRCC4 -rs1805377, XRCC7 -rs7003908) included in current meta-analysis (Agalliu et al, 2010, Andrew et al, 2015, Andrew et al, 2007, Andrew et al, 2006, Arizono et al, 2008, Berhane et al, 2012, Broberg et al, 2005, Chang et al, 2009, Lan et al, 2006, Lavender et al, 2010, Chang et al, 2008, Dhillon et al, 2009, Figueroa et al, 2007a, Figueroa et al, 2007b, Fontana et al, 2008, Gangwar et al, 2009, Hamano et al, 2008, Hirata et al, 2006, Hirata et al, 2007, Huang et al, 2007, Abe et al, 2011, Mittal et al, 2008, Narter et al, 2009, Nowacka-Zawisza et al, 2015, Ramaniuk et al, 2014, Ritchey et al, 2005, Rybicki et al, 2004, Sak et al, 2007, Sanyal et al, 2004, Shen et al, 2003, Stern et al, 2002, Stern et al, 2001, Van Gils et al, 2002, Wang et al, 2010, Wang et al, 2008, Wen et al, 2009, Wen et al, 2013, Wu et al, 2006, Xu et al, 2007, Zhi et al, 2012, Hao et al, 2008, Zhou et al, 2012, Zhu et al, 2014, Zhu et al, 2012, Kelsey et al, 2004, Kuasne et al, 2011, Luedeke et al, 2009, Mandal et al, 2010, Mandal et al, 2011, Matullo, 2005, Matullo et al, 2006, Matullo et al, 2001, Mittal et al, 2012a, Mittal et al, 2012b). The study selection processes were presented in Supplementary Figs.…”

Section: Resultsmentioning

confidence: 99%

Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis

Zhang¹,

Li²,

Hao³

et al. 2017

EBioMedicine

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Polymorphisms in X-ray repair cross-complementing (XRCC) genes have been implicated in altering the risk of various urological cancers. However, the results of reported studies are controversial. To ascertain whether polymorphisms in XRCC genes are associated with the risk of urological neoplasms, we conducted present updated meta-analysis and systematic review. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the association. Finally, 54 publications comprising 129 case-control studies for twelve polymorphisms in five XRCC genes were enrolled. We identified that XRCC1-rs25489 polymorphism was associated with an increased risk of urological neoplasms in heterozygote and dominant models. Moreover, in the subgroup analysis by cancer type, we found that XRCC1-rs25489 polymorphism was associated with an increased risk of bladder cancer (BC) in heterozygote model. Although overall analyses suggested a null result for XRCC1-rs25487 polymorphism, in the stratified analysis by ethnicity, an increased risk of urological neoplasms for Asians in allelic and homozygote models was identified. While for other polymorphisms in XRCC genes, no significant association was uncovered. To sum up, our results indicated that XRCC1-rs25489 polymorphism is a risk factor for urological neoplasms, particularly for BC. Further studies with large sample size are needed to validate these findings.

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Section: Resultsmentioning

confidence: 99%

Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis

Zhang¹,

Li²,

Hao³

et al. 2017

EBioMedicine

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“…Moreover, Guo et al (2015) established that this same variant might be correlated with increased risk of breast cancer using a meta-analysis of 13 published case-control studies. However, Hsu et al (2015) found no significant association between XRCC1 gene polymorphisms and skin cancer risk, although in a case-control study, Zhu et al (2015) demonstrated that individuals carrying the Arg194Trp variation in this gene are more susceptible to prostate cancer. Several investigators have scrutinized the association between XRCC1 gene polymorphisms and gastric cancer risk, but their results have been inconsistent (Yan et al, 2009;Engin et al, 2011;Yuan et al, 2011;Karahalil et al, 2012;Pan et al, 2012;Wen et al, 2012).…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies have reported associations between XRCC1 sequence variations and development of several cancers, including those of the lung, colorectum, ovary, breast, skin, and prostate (Guo et al, 2015;Han et al, 2015;Hsu et al, 2015;Malisic et al, 2015;Nissar et al, 2015;Zhu et al, 2015). For example, Han et al (2015) conducted a case-control study, reporting that the Arg399Gln polymorphism significantly elevates susceptibility to non-small cell lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer

et al. 2016

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ABSTRACT. We carried out a hospital-based case-control study to investigate the role of XRCC1 gene Arg399Gln, Arg280His, and Arg194Trp polymorphisms in susceptibility to gastric cancer. A total of 214 gastric cancer patients and 247 control subjects were recruited between March 2013 and March 2015, and polymorphism genotype frequencies were determined by polymerase chain reactionrestriction fragment length polymorphism. Using the chi-square test, we detected statistically significant differences in age (chi-square = 22.25, P < 0.001), gender (chi-square = 6.74, P = 0.01), and family history of cancer (chi-square = 4.73, P = 0.03) between the case and control groups. Logistic regression analysis revealed that the XRCC1 Arg194Trp TT genotype conferred increased susceptibility to gastric cancer compared to the CC genotype [odds ratio (OR) = 2.38, 95% confidence interval (CI) = 1.28-4.49]. Moreover, individuals carrying the T allele of this variant were found to be at moderately increased risk of this disease (OR = 1.56, 95%CI = 1.16-2.09). However, the XRCC1 2 S. Chen et al. Genetics and Molecular Research 15 (3): gmr.15038342 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer. In conclusion, we suggest that the XRCC1 gene Arg194Trp polymorphism is associated with gastric cancer susceptibility in the Chinese population.

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“…Previous studies have assessed the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms in the development of several types of cancers, such as non-small cell lung cancer (NSCLC), prostate cancer, glioma, breast cancer, ovarian cancer, and colorectal cancer (Kang et al, 2015;Han et al, 2015;Zhu et al, 2015;Wang et al, 2015;Guo et al, 2015;Malisic et al, 2015;Nissar et al, 2015). For example, Kang et al (2015) conducted a study on 210 NSCLC patients and 210 health control subjects in China to investigate the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms in the risk of NSCLC.…”

Section: Discussionmentioning

confidence: 99%

“…They found that the XRCC1 Arg194Trp polymorphism increased the risk of NSCLC development. Zhu et al (2015) examined the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp polymorphisms in the risk of prostate cancer, and showed an increased risk for prostate cancer in individuals with the XRCC1 Arg194Trp polymorphism. Wang et al (2015) conducted a study on 387 glioma patients and 400 cancer-free controls, and found that the XRCC1 Arg399Gln polymorphism was associated with glioma susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population

Wang

2016

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to assess the role of the XRCC1 Arg399Gln, Arg280His, and Arg194Trp gene polymorphisms in pancreatic cancer susceptibility in a Chinese population. A total of 152 patients diagnosed with pancreatic cancer and 264 control subjects were enrolled in this study between March 2012 and October 2014. XRCC1 Arg399Gln, Arg280His, and Arg194Trp were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. As determined by the chi-squared test, a statistically significant difference was observed between pancreatic cancer patients and control subjects in regard to the genetic distribution of XRCC1 Arg399Gln (χ 2 = 16.13, P < 0.001). Using an unconditional regression analysis, we found that the TT genotype of Arg399Gln was associated with a significantly increased risk of pancreatic cancer (OR = 2.33, 95%CI = 1.20-4.51), and that the CT+TT genotype also significantly increased pancreatic cancer risk (OR = 1.58, 95%CI = 1.04-2.41), compared to the wild-type genotype. In conclusion, we found that XRCC1 Arg399Gln genetic variations are associated with pancreatic cancer development, whereas the XRCC1 Arg280His and Arg194Trp polymorphisms did not affect pancreatic cancer risk.

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Impact of polymorphisms of the DNA repair gene XRCC1 and their role in the risk of prostate cancer

Cited by 10 publications

References 22 publications

Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis

Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis

Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer

Association of XRCC1 gene polymorphisms and pancreatic cancer risk in a Chinese population

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