Impact of placental insufficiency on fetal skeletal muscle growth

Brown, Laura D.; Hay, William W.

doi:10.1016/j.mce.2016.03.017

Cited by 68 publications

(62 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, we found that subjects in the catch-up group had higher gestational age than those in the non-catch-up group. In the current study, the placental weight of SGA subjects was lower than AGA subjects, which was in accordance with a previous study that showed that lighter placenta provided insufficient substance 29 .…”

Section: Discussionsupporting

confidence: 93%

Height at three months can indicate overweight at two years in catch-up growth of small for gestational age infants

Chen

Liu

Zhu

et al. 2018

Sci Rep

View full text Add to dashboard Cite

This study aimed to find an indicator at three months to predict overweight and short stature at two years in small for gestational age (SGA) infants. A total of 468 SGA infants and 4642 appropriate for gestational age (AGA) infants were included. Weight and height were measured at birth, three months and two years. Logistic regression and receiver operating characteristic (ROC) curves were performed for the catch-up growth. As compared to AGA infants, the weight of SGA infants was lower and the length/height was shorter at birth, three months, and two years. The weight of the catch-up group was significantly greater at birth and two years. The length/height of the catch-up group was greater at three months and two years. Trajectories of weight standard deviation score (SDS) and height SDS showed that the overweight group (BMI over the 85th percentile) had a shorter length/height SDS but a higher rate of the change in weight SDS during catch-up growth. The multivariate logistic regression indicated that that height at three months was an independent factor for prediction of catch-up growth at two years. The area under curve (AUC) was 0.801 with the 95% confidence interval (CI) from 0.726 to 0.876. Therefore, height at three months can predict overweight at two years.

show abstract

Section: Discussionsupporting

confidence: 93%

Height at three months can indicate overweight at two years in catch-up growth of small for gestational age infants

Chen

Liu

Zhu

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…). A large number of epidemiological studies show that birthweight, when used as an index of the effect of the intrauterine environment on fetal growth, is positively correlated with lean mass in adulthood (Brown & Hay, ). As an example, a slower trajectory of muscle growth during childhood was observed in children who were born small for gestational age compared to those children who were born with an appropriate birth weight (Baker et al .…”

Section: Introductionmentioning

confidence: 99%

Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth‐restricted fetal sheep

Rozance

Zastoupil

Wesolowski

et al. 2017

The Journal of Physiology

Self Cite

139

View full text Add to dashboard Cite

Key pointsr Adults who were affected by intrauterine growth restriction (IUGR) suffer from reductions in muscle mass, which may contribute to insulin resistance and the development of diabetes.r We demonstrate slower hindlimb linear growth and muscle protein synthesis rates that match the reduced hindlimb blood flow and oxygen consumption rates in IUGR fetal sheep. These adaptations resulted in hindlimb blood flow rates in IUGR that were similar to control fetuses on a weight-specific basis.r Net hindlimb glucose uptake and lactate output rates were similar between groups, whereas amino acid uptake was significantly lower in IUGR fetal sheep.r Among all fetuses, blood O 2 saturation and plasma glucose, insulin and insulin-like growth factor-1 were positively associated and norepinephrine was negatively associated with hindlimb weight.r These results further our understanding of the metabolic and hormonal adaptations to reduced oxygen and nutrient supply with placental insufficiency that develop to slow hindlimb growth and muscle protein accretion.Abstract Reduced skeletal muscle mass in the fetus with intrauterine growth restriction (IUGR) persists into adulthood and may contribute to increased metabolic disease risk. To determine how placental insufficiency with reduced oxygen and nutrient supply to the fetus affects hindlimb blood flow, substrate uptake and protein accretion rates in skeletal muscle, late gestation control (CON) (n = 8) and IUGR (n = 13) fetal sheep were catheterized with aortic and femoral catheters and a flow transducer around the external iliac artery. Muscle protein kinetic rates were measured using isotopic tracers. Hindlimb weight, linear growth rate, muscle protein accretion rate and fractional synthetic rate were lower in IUGR compared to CON (P < 0.05). Absolute hindlimb blood flow was reduced in IUGR (IUGR: 32.9 ± 5.6 ml min −1 ; CON: 60.9 ± 6.5 ml min −1 ; P < 0.005), although flow normalized to hindlimb weight was similar between groups. Hindlimb oxygen consumption rate was lower in IUGR (IUGR: 10.4 ± 1.4 μmol min −1 100 g −1 ; CON: 14.7 ± 1.3 μmol min −1 100 g −1 ; P < 0.05). Hindlimb glucose uptake and lactate output rates were similar between groups, whereas amino acid uptake was lower in IUGR (IUGR: 1.3 ± 0.5 μmol min −1 100 g −1 ; CON: 2.9 ± 0.2 μmol min −1 100 g −1 ; P < 0.05). Blood O 2 saturation (r 2 = 0.80, P < 0.0001) and plasma glucose (r 2 = 0.68, P < 0.0001), insulin (r 2 = 0.40, P < 0.005) and insulin-like growth factor (IGF)-1 (r 2 = 0.80, P < 0.0001) were positively associated and norepinephrine (r 2 = 0.59, P < 0.0001) was negatively associated with hindlimb weight. Slower hindlimb linear growth and muscle protein synthesis rates match reduced hindlimb blood flow and oxygen consumption rates in the IUGR fetus. Metabolic adaptations to slow hindlimb growth are probably hormonally-mediated by mechanisms that include increased fetal norepinephrine and reduced IGF-1 and insulin.

show abstract

“…Key stages of skeletal muscle development occur during early embryonic stage, mid pregnancy, and postnatally [6][7][8]. Especially, the mid gestational period can have long-term consequences to offspring muscle strength and function [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of maternal weight during pregnancy on offspring muscle strength response to resistance training in late adulthood

Wasenius

Simonen

Penttinen

et al. 2018

Advances in Medical Sciences

View full text Add to dashboard Cite

show abstract

Impact of placental insufficiency on fetal skeletal muscle growth

Cited by 68 publications

References 138 publications

Height at three months can indicate overweight at two years in catch-up growth of small for gestational age infants

Height at three months can indicate overweight at two years in catch-up growth of small for gestational age infants

Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth‐restricted fetal sheep

Effect of maternal weight during pregnancy on offspring muscle strength response to resistance training in late adulthood

Contact Info

Product

Resources

About