Impact of physiological aging on lower limb venous compliance

Lopes, Amanda; Lloret‐Linares, Célia; Simoneau, Guy G.; Lévy, Bernard; Jf, Bergmann; Mouly, Stéphane

doi:10.1016/j.eurger.2012.12.005

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…Second, all the enrolled subjects were designedly aged between 20 and 60 years old and this did not allow to effectively investigate the influence of aging, which is generally associated with vessel wall remodeling and stiffening (44,45). To deepen age-related differences, the study population should be further extended including elderly people, i.e., largely over 60 years old (45).…”

Section: Limitationsmentioning

confidence: 99%

Non-invasive estimation of vascular compliance and distensibility in the arm vessels: a novel ultrasound-based protocol

Cappelletti

Caimi

Caldiroli

et al. 2022

Quant Imaging Med Surg

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Background: Performance and durability of arterio-venous grafts depend on their ability to mimic the mechanical behavior of the anastomized blood vessels. To select the most suitable synthetic graft, in vivo evaluation of the radial deformability of peripheral arteries and veins could be crucial; however, a standardized non-invasive strategy is still missing. Herein, we sought to define a novel and user-friendly clinical protocol for in vivo assessment of the arm vessel deformability.Methods: A dedicated protocol, applied on 30 volunteers, was specifically designed to estimate both compliance and distensibility of the brachial and radial arteries, and of the basilic and cephalic veins. Bidimensional ultrasound imaging was used to acquire cross-sectional areas (CSAs) of arteries in clinostatic configuration, and CSAs of veins combining clinostatic and orthostatic configurations. Arterial pulse pressure was measured with a digital sphygmomanometer, while venous hydrostatic pressure was derived from the arm length in orthostatic configuration.Results: For each participant, all CSAs were successfully extracted from ultrasound images. The basilic vein and the radial artery exhibited the largest (21.5±8.9 mm 2 ) and the smallest (3.4±1.0 mm 2 ) CSAs, respectively; CSA measurements were highly repeatable (Bland-Altman bias <10% and Pearson correlation ≥0.90, for both arteries and veins). In veins, compliance and distensibility were higher than in arteries; compliance was significantly higher (P<0.0001) in the brachial than in the radial artery (3.52×10 −4 vs. 1.3×10 −4 cm 2 /mmHg); it was three times larger in basilic veins than in cephalic veins (17.4×10 −4 vs. 5.6×10 −4 cm 2 /mmHg, P<0.0001). Conclusions:The proposed non-invasive protocol proved feasible, effective and adequate for daily clinical practice, allowing for the estimation of patient-specific compliance and distensibility of peripheral arteries and veins. If further extended, it may contribute to the fabrication of biohybrid arterio-venous grafts, paving the way towards patient-tailored solutions for vascular access.

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Section: Limitationsmentioning

confidence: 99%

Non-invasive estimation of vascular compliance and distensibility in the arm vessels: a novel ultrasound-based protocol

Cappelletti

Caimi

Caldiroli

et al. 2022

Quant Imaging Med Surg

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“…Since collagen is far stiffer than elastin this results in less complaint arterial vessel walls with advancing age. The authors are aware of only one other series reporting venous compliance in relation to age which showed an inverse relationship between age and vein compliance during in vivo testing in healthy volunteers 15 . The explanation for this difference on outcomes is unclear however the simplistic explanation of the degradation of elastin and increased relative concentration to collagen may not be a complete reflection of the structural changes occurring in vessel walls.…”

Section: Accepted Manuscriptmentioning

confidence: 97%

The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes

Smith

Barnes

Fagan

et al. 2016

Annals of Vascular Surgery

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“…Regarding the compliance of venous conduits in AVFs, two studies on human patients that included biomechanical evaluation either by plethysmography ( 136 ) or by dynamic mechanical analysis ( 137 ) have demonstrated higher failure rates with reduced venous compliance (i.e., with increased stiffness). It has also been reported that venous compliance decreases naturally with age ( 138 ) and that in hypertensive hemodialysis patients, the compliance is reduced irreversibly ( 139 ). These findings seem to cast doubt on the possibility of preventing NIH by reducing venous compliance, achievable through the cross-linking of vascular collagen.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance

Russu,

Arbanasi,

Chirila

et al. 2024

Front. Cardiovasc. Med.

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We have reviewed the development and current status of therapies based on exposure to non-ionizing radiation (with a photon energy less than 10 eV) aimed at suppressing the venous neointimal hyperplasia, and consequentially at avoiding stenosis in arteriovenous grafts. Due to the drawbacks associated with the medical use of ionizing radiation, prominently the radiation-induced cardiovascular disease, the availability of procedures using non-ionizing radiation is becoming a noteworthy objective for the current research. Further, the focus of the review was the use of such procedures for improving the vascular access function and assuring the clinical success of arteriovenous fistulae in hemodialysis patients. Following a brief discussion of the physical principles underlying radiotherapy, the current methods based on non-ionizing radiation, either in use or under development, were described in detail. There are currently five such techniques, including photodynamic therapy (PDT), far-infrared therapy, photochemical tissue passivation (PTP), Alucent vascular scaffolding, and adventitial photocrosslinking. The last three are contingent on the mechanical stiffening achievable by the exogenous photochemical crosslinking of tissular collagen, a process that leads to the decrease of venous compliance. As there are conflicting opinions on the role of compliance mismatch between arterial and venous conduits in a graft, this aspect was also considered in our review.

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Impact of physiological aging on lower limb venous compliance

Cited by 3 publications

References 20 publications

Non-invasive estimation of vascular compliance and distensibility in the arm vessels: a novel ultrasound-based protocol

Non-invasive estimation of vascular compliance and distensibility in the arm vessels: a novel ultrasound-based protocol

The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes

Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance

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