Impact of parental multiple sclerosis on early childhood development: A retrospective cohort study

Razaz, Neda; Tremlett, Helen; Boyce, W. Thomas; Guhn, Martin; Joseph, K. S.; Marrie, Ruth Ann

doi:10.1177/1352458514559298

Cited by 15 publications

(25 citation statements)

References 32 publications

(56 reference statements)

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“…Several studies indicate parental mental health, emotional distress, and expressed emotions are more important determinants for the impact of MS on their offspring's psychosocial development (Bogosian et al, ; Razaz et al, ; Razaz, Joseph, et al, ) than the severity and type of MS. Therefore, the lack of information on mental health problems of the mother is a limitation of this study.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study using the strengths and difficulties questionnaire (SDQ) to measure psychosocial development confirms the association between mental health problems of parents with MS and increased internalizing and externalizing symptoms affecting their children (Bogosian, Hadwin, Hankins, & Moss‐Morris, ). Other studies find no adverse association of parental MS with children's development outcomes (Razaz et al, ) and no difference in overall difficulties between children of parents with MS and the general community (Steck et al, ), and some studies have shown an increase in prosocial behavior (Pakenham & Cox, ) and an increased feeling of being more empathic and grown‐up than peers (Bogosian, Moss‐Morris, Bishop, & Hadwin, ).…”

Section: Introductionmentioning

confidence: 99%

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Mental health among children of mothers with multiple sclerosis: A Danish cohort and register‐based study

et al. 2018

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BackgroundMultiple sclerosis is associated with an increased risk of developing physical, cognitive, and mental health problems. Current studies have demonstrated variating outcomes of parental multiple sclerosis mental health problems and their children's mental health development.ObjectiveThe purpose of this study was to investigate whether maternal multiple sclerosis is associated with the mental health status of their child.MethodsData from the Danish National Birth Cohort (DNBC) were merged with information from the Danish Multiple Sclerosis Registry. Two proxies, total difficulties score and prediction of any psychiatric diagnosis based on the strengths and difficulties questionnaire, were used to measure the mental health status of the children. The two groups were compared using Mann–Whitney and logistic regression analyses.ResultsFor the total difficulties score the control and exposed group consisted of respectively n = 42,016 and n = 40, and for the prediction of any psychiatric diagnosis respectively n = 16,829 and n = 17. We found no statistically significant association between maternal multiple sclerosis and mental health status on neither of the proxies.ConclusionMaternal multiple sclerosis did not show any association with the mental health status of their children at age eleven. On the contrary, other studies conclude that there is an association between maternal multiple sclerosis and the child's mental health status, one especially mediated by the maternal mental health status.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mental health among children of mothers with multiple sclerosis: A Danish cohort and register‐based study

et al. 2018

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“…Some studies indicate that women with MS may have higher risk for delivering neonates with lower birth weight compared with healthy women [15][16][17] . Thus far no long-term adverse pediatric outcomes have been reported 18,19 .…”

Section: Fetal Developmentmentioning

confidence: 99%

Pregnancy-related issues in women with multiple sclerosis: an evidence-based review with practical recommendations

Canibaño

Deleu

Mesraoua

et al. 2020

Journal of Drug Assessment

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Objective: To review the current evidence regarding pregnancy-related issues in multiple sclerosis (MS) and to provide recommendations specific for each of them. Research design and methods: A systematic review was performed based on a comprehensive literature search. Results: MS has no effect on fertility, pregnancy or fetal outcomes, and pregnancies do not affect the long-term disease course and accumulation of disability. There is a potential risk for relapse after use of gonadotropin-releasing hormone agonists during assisted reproduction techniques. At short-term, pregnancy leads to a reduction of relapses during the third trimester, followed by an increased risk of relapses during the first three months postpartum. Pregnancies in MS are not per se high risk pregnancies, and MS does not influence the mode of delivery or anesthesia unless in the presence of significant disability. MRI is not contraindicated during pregnancy; however, gadolinium contrast media should be avoided whenever possible. It is safe to use pulse dose methylprednisolone infusions to manage acute disabling relapses during pregnancy and breastfeeding. However, its use during the first trimester of pregnancy is still controversial. Women with MS should be encouraged to breastfeed with a possible favorable effect of exclusive breastfeeding. Disease-modifying drugs can be classified according to their potential for pregnancy-associated risk and impact on fetal outcome. Interferon beta (IFNb) and glatiramer acetate (GA) may be continued until pregnancy is confirmed and, after consideration of the individual risk-benefit if continued, during pregnancy. The benefit of continuing natalizumab during the entire pregnancy may outweigh the risk of recurring disease activity, particularly in women with highly active MS. GA and IFNb are considered safe during breastfeeding. The use of natalizumab during pregnancy or lactation requires monitoring of the newborn. Conclusions: This review provides current evidence and recommendations for counseling and management of women with MS preconception, during pregnancy and postpartum.

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“…Consequently, children of a parent with MS have demonstrated greater levels of distress, behavioural problems, and negative psychosocial behaviour compared with children of parents without MS . On the other hand, some studies have reported that children of a parent with MS and children of parents without MS do not differ on adjustment and developmental outcomes, except for adverse peer relationship issues …”

mentioning

confidence: 99%

“…Depression and anxiety affect individuals with MS at more than twice the frequency observed among people without MS . Chronic exposure to maternal depressive symptoms has been consistently shown to have an adverse effect on children's mental health . Given the high prevalence of mental health co‐morbidity among people with MS, it is possible that parental mental health mediates the relationship between parental MS and mental health outcomes in their children.…”

mentioning

confidence: 99%

Incidence of Mood or Anxiety Disorders in Children of Parents with Multiple Sclerosis

Razaz

Tremlett

Boyce

et al. 2016

Paediatric Perinatal Epid

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Background: Although parental multiple sclerosis (MS) may put children at increased risk for mental health disorders such as anxiety and depression, the incidence and determinants of such disorders have not been examined. Method: We carried out a retrospective cohort study in British Columbia, Canada, among children of parents with MS and age-matched children of unaffected parents. Cox regression was used to estimate the association between parental MS and mood or anxiety disorders in children. Results: The study included 1028 children of MS parents, 4010 children of unaffected parents, and 25 464 childyears of follow-up (median follow-up of 4 years). Mental health morbidity was more common among MS parents vs. unaffected parents (50.4% vs. 33.1%) and among MS-affected mothers vs. unaffected mothers (54.6% vs. 38.0%, P < 0.001). The incidence of child mood or anxiety disorders was 8.3 and 6.3 per 1000 child-years among children of parents with and without MS respectively. Sex of the MS-affected parent modified the relationship between parental MS and mood or anxiety disorders in children (P = 0.04). Compared with children of unaffected mothers, children of mothers affected by MS had higher rates of mood or anxiety disorders (HR 1.7, 95% CI 1.1, 2.4), whereas children of MS-affected fathers did not (HR 0.5, 95% CI 0.2, 1.7). Adjustment for mental health morbidity in mothers diminished the association between maternal MS and child mood or anxiety disorders. Conclusion: Maternal MS is associated with a higher rate of mood or anxiety disorders in children and this association appeared to be mediated by maternal mental health morbidity.

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Impact of parental multiple sclerosis on early childhood development: A retrospective cohort study

Cited by 15 publications

References 32 publications

Mental health among children of mothers with multiple sclerosis: A Danish cohort and register‐based study

Mental health among children of mothers with multiple sclerosis: A Danish cohort and register‐based study

Pregnancy-related issues in women with multiple sclerosis: an evidence-based review with practical recommendations

Incidence of Mood or Anxiety Disorders in Children of Parents with Multiple Sclerosis

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