Impact of Oxidative Stress on Inflammation in Rheumatoid and Adjuvant Arthritis: Damage to Lipids, Proteins, and Enzymatic Antioxidant Defense in Plasma and Different Tissues

Poništ, Silvester; Zloh, Miloslav; Bauerová, Katarína

doi:10.5772/intechopen.89480

Cited by 16 publications

(15 citation statements)

References 99 publications

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“…Increased oxidative stress in inflamed joints is considered as a mediator of inflammation, which appears after arthritis induction. During inflammation, different cell types, such as macrophages and neutrophils, play a major role in the production of reactive oxygen species, leading to lipid peroxidation and imbalance in antioxidant status (37). The role of the joint in the production of reactive oxygen species is also important in the development of arthritis.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes

Dadaya

Koubala

Abaissou

et al. 2021

J Herbmed Pharmacol

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Introduction: Siphonochilus aethiopicus is a medicinal plant widely used in the treatment of many inflammatory conditions such as arthritis. The objective of this study was therefore to evaluate the antioxidant and anti-inflammatory properties of methanolic extract of S. aethiopicus rhizomes. Methods: The total phenolic compounds, flavonoid, and tannin content, as well as the in vitro antioxidant activity of the extract, were estimated. The in vivo anti-inflammatory activity was then evaluated in male mice aged 3 to 4 months using the arthritic mouse model induced by carrageenan (0.05 ml; 1%) and monosodium urate (MSU) crystals (26.6 mg/mL). Mice were treated with the methanolic extract of S. aethiopicus (75, 150, 300 mg/kg) and the reference drugs: indomethacin (3 mg/kg) and colchicine (1 mg/kg). The serum, splenic, and hepatic lysosomal enzymes were determined, and oxidative stress biomarkers were estimated. Paws were sectioned for histological analysis. Results: Results showed that S. aethiopicus extract had non-negligible concentrations of polyphenols, flavonoids, and tannins, which could confer it an antioxidant effect. Further, the methanolic extract of S. aethiopicus at different doses significantly (P < 0.05) reduced paw swelling, attenuated joint inflammation, limited the release of lysosomal enzymes, and improved antioxidant enzymes. Conclusion: The methanolic extract of S. aethiopicus has anti-inflammatory and antioxidant properties, and can be used to treat acute forms of gouty arthritis.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes

Dadaya

Koubala

Abaissou

et al. 2021

J Herbmed Pharmacol

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“…The formation of NO is elevated in inflammatory arthritis and contributes towards inflammation of synovium and cartilage [ 98 ]. Both OS and inflammation are deemed to be the most important role players in the pathogenesis of RA [ 99 ]. Unbalanced buildup of ROS/RNS leads to pathophysiological events, such as neurodegenerative disorders, cancer, cardiovascular maladies, and chronic inflammation, because of OS [ 100 , 101 ].…”

Section: Selenium Nanoparticlesmentioning

confidence: 99%

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

2021

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Rheumatoid arthritis (RA) is a common chronic inflammation-mediated disorder having systematic complications. RA triggers a self-directed inflammatory and immunological cascade that culminates in joint destruction. Though a range of treatment options are available, none of them are without adverse effects and this has led researchers to search for alternative solutions. Nanomedicine has emerged as a powerful therapeutic alternative, and selenium (Se) is an essential micronutrient trace element that has a crucial role in human health and disease. Selenium nanoparticles (SeNPs) derived from biological sources, such as plants, bacteria, fungi, and proteins, have exhibited remarkable candidate properties and toxicological profiles, and hence have shown potential to be used as antirheumatic agents. The potential of SeNPs can be attributed to the effect of functional groups bound to them, concentration, and most importantly to their nano range size. The antirheumatic effect of SeNPs is considerable due to its potential in amelioration of oxidative stress-mediated inflammation via downregulation of radical and nonradical species, markers of inflammation, and upregulation of inherent antioxidant defenses. The size and concentration impact of SeNPs has been shown in the subsequent antioxidant and anti-inflammatory properties. Moreover, the article emphasizes the role of these biogenic SeNPs as a notable option in the nanomedicine arena that needs to be further studied as a prospective remedial alternative to cure RA and medication-related adverse events.

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“…Genetic and environmental factors are linked to RA through various proposed mechanisms such as oxidative stress, apoptosis, pro‐inflammatory cytokine production, activation of TNF‐α, and autoantibodies production (Harel‐Meir et al., 2007; Ponist et al., 2019; Quinonez‐Flores et al., 2016). Unregulated inflammation as in RA results in oxidative stress as well as tissue damage.…”

Section: Introductionmentioning

confidence: 99%

Probing the antioxidant potential of Juglans regia (walnut) against arthritis‐induced oxidative stress in Sprague Dawley rats

Javed

Rakha

Butt

et al. 2022

Journal of Food Biochemistry

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Oxidative stress is the underlying cause of various chronic diseases and can contribute to its progression. Plant‐based therapeutics are effective in the prevention of various chronic diseases through the management of underlying causes. Walnuts owing to their rich phytochemistry possess antioxidative potential. In this context, the present research was designed to explore the therapeutic potential of walnut against arthritis‐induced oxidative stress in rat model. Purposely, 50 Sprague Dawley rats were separated into five groups of 10 rats each. The rats were categorized as G0 (negative control), G1 (positive control), G2 (methotrexate), G3 (walnut feed), and G4 (walnut extract). Walnut feed and extract significantly reduced oxidative stress by improving the antioxidant enzymes in arthritic rats. Total oxidative stress was reduced by 41.44% and 21.52% in G3 while 52.81% and 36.76% in G4 when compared with G1 and G2, respectively. Antioxidant enzyme levels in serum were significantly improved after the walnut‐based interventions. Evidently, superoxide dismutase level improved by 74.5% in G3 and 83.40% in G4, while catalase level increased by 51.99% in G3 and 61.34% in G4, respectively, when compared with G1. Liver function biomarkers, that is, ALP and AST, were decreased in G3 and G4 when compared with G1 and G2. The histopathological examination illustrated the promising role of walnut‐based interventions in conserving the structural integrity of hepatic and renal tissues. Meanwhile, gene expression analysis revealed that walnut treatments protected from oxidative damage by the downregulation of Dual‐oxidases expression. Conclusively, walnut feed and extract might serve as potent antioxidant intervention with no potential side effects. Practical applications The present work was aimed to evaluate the efficacy of walnut‐based interventions against arthritis‐induced oxidative stress. The walnut‐based interventions positively modulated the antioxidant enzymes, liver, and kidney functions, while downregulating the gene associated with oxidative stress in animal model. Consequently, the current findings suggest wider applications of walnuts to avoid free radical induced damage during arthritis; however, human intervention studies may be carried out to further understand the mechanism of their bioefficacy.

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Impact of Oxidative Stress on Inflammation in Rheumatoid and Adjuvant Arthritis: Damage to Lipids, Proteins, and Enzymatic Antioxidant Defense in Plasma and Different Tissues

Cited by 16 publications

References 99 publications

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes

Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications

Probing the antioxidant potential of Juglans regia (walnut) against arthritis‐induced oxidative stress in Sprague Dawley rats

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