Probing the antioxidant potential of
            <i>Juglans regia</i>
            (walnut) against arthritis‐induced oxidative stress in
            <i>Sprague Dawley</i>
            rats

Javed, Komal; Rakha, Allah; Butt, Masood Sadiq; Faisal, Muhammad Naeem

doi:10.1111/jfbc.14082

Cited by 2 publications

(5 citation statements)

References 81 publications

(114 reference statements)

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“…Moreover, RA-related renal and hepatic damage, measured by classical biochemical markers (AST, ALT, creatinine) and histological evaluation, were reverted by both treatments. Unfortunately, no data regarding inflammatory markers were collected [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

et al. 2022

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Plants rich in hydrolyzable tannins were traditionally used all over the world for a variety of chronic inflammatory disorders, including arthritis, colitis, and dermatitis. However, the knowledge of their immunological targets is still limited though fundamental for their rational use in phytotherapy. The recent advances regarding the pathogenesis of inflammatory-based diseases represent an opportunity to elucidate the pharmacological mechanism of plant-derived metabolites with immunomodulatory activity. This review collects recent articles regarding the role of hydrolyzable tannins and their gut metabolites in Th1, Th2, and Th17 inflammatory responses. In line with the traditional use, rheumatoid arthritis (RA), inflammatory bowel diseases (IBDs), psoriasis, atopic dermatitis (AD), and asthma were the most investigated diseases. A substantial body of in vivo studies suggests that, beside innate response, hydrolyzable tannins may reduce the levels of Th-derived cytokines, including IFN-γ, IL-17, and IL-4, following oral administration. The mode of action is multitarget and may involve the impairment of inflammatory transcription factors (NF-κB, NFAT, STAT), enzymes (MAPKs, COX-2, iNOS), and ion channels. However, their potential impact on pathways with renewed interest for inflammation, such as JAK/STAT, or the modulation of the gut microbiota demands dedicate studies.

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Section: Resultsmentioning

confidence: 99%

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

et al. 2022

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“…Ethanolic extracts of walnut were obtained by following the method of Fregapane et al (2020) subsequently modified by Javed et al (2022). Purposely, finely ground walnut powder (25 g) was extracted with 70% ethanol along with ultrasonication (D78224 Singen/Htw, Elma, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…Ethanolic extracts of walnut were obtained by following the method of Fregapane et al (2020) subsequently modified by Javed et al (2022).…”

Section: Solvent Extraction Of Walnutsmentioning

confidence: 99%

“…Moreover, they play an important role in alleviating oxidative stress by downregulating ROS and upregulating antioxidant enzymes, thus exhibiting anti-arthritic potential (Javed et al, 2022). Furthermore, they are involved in different signaling pathways that regulate a wide range of biological functions including proand anti-inflammatory pathways, bone modeling and remodeling signaling pathway, and intrinsic and extrinsic pathways of apoptosis (Kahkeshani et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Gallic and ellagic acids have demonstrated anti‐inflammatory activities via inhibiting the expression of different inflammatory mediators such as pro‐inflammatory chemokine and cytokines, cyclooxygenase‐2 (COX‐2), and gene expression (BenSaad et al, 2017; Yoon et al, 2013). Moreover, they play an important role in alleviating oxidative stress by downregulating ROS and upregulating antioxidant enzymes, thus exhibiting anti‐arthritic potential (Javed et al, 2022). Furthermore, they are involved in different signaling pathways that regulate a wide range of biological functions including pro‐ and anti‐inflammatory pathways, bone modeling and remodeling signaling pathway, and intrinsic and extrinsic pathways of apoptosis (Kahkeshani et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the anti‐arthritic potential of walnut ( Juglans regia L.) in FCA induced Sprague Dawley rats

Javed

Rakha

Butt

et al. 2022

Journal of Food Biochemistry

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Rheumatoid arthritis (RA) is an autoimmune progressive disease, associated with many pathophysiological consequences. Owing to the adverse effects and higher costs of pharmaceuticals, people are now looking for complementary and alternative remedies. In this milieu, the present study was designed to explore the therapeutic potential of walnuts against FCA‐induced arthritis in rat models. Purposely, 50 Sprague Dawley rats were housed in a well‐ventilated animal room and separated into 5 groups of 10 rats each. The rats were categorized as G0 (negative control), G1 (positive control, i.e., FCA induced untreated arthritic rats), G2 (arthritic rats treated with MTX), G3 (arthritic rats treated with walnut feed), and G4 (arthritic rats treated with walnut extract), with an efficacy trial lasting for 42 days. The physical analysis explicated that paw swelling was significantly improved by 10%–12.8% in treatment groups after the intervention when compared with positive control. Moreover, biochemical analyses revealed significantly lower levels of ESR, CRP, and RF in rats treated with walnut‐based interventions when compared to positive control. ESR values were decreased by 62.4% and 69.92% in G3 and G4, whereas CRP levels were improved by 56.20% and 77.78% in G3 and G4 when compared with G1. Likewise, RF values decreased in G2, G3, and G4 by 64.71%, 55.88%, and 69.24%, respectively when compared to G1. The histological examination demonstrated the potential role of walnut‐based interventions in reducing the severity of disease by decreasing cell infiltration, bone erosion, and paw inflammation. Meanwhile, the gene expression analysis revealed that walnut‐based interventions protected the paw joints from damage by downregulating the RANKL‐OPG pathway. Conclusively, walnut feed and extract may serve as potent anti‐arthritic interventions with no side effects. Practical applications Plant‐based therapeutics are effective in the prevention and management of various chronic diseases. The current research explored the anti‐arthritic potential of walnuts. Walnut feed and extract effectively reduced the serum arthritic biomarkers as well as downregulated the genes involved in bone destruction. Thus, the inclusion of dietary ingredients having therapeutic potential such as walnuts may be synchronized in clinical practices to ameliorate arthritis.

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Probing the antioxidant potential of Juglans regia (walnut) against arthritis‐induced oxidative stress in Sprague Dawley rats

Cited by 2 publications

References 81 publications

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases

Evaluating the anti‐arthritic potential of walnut ( Juglans regia L.) in FCA induced Sprague Dawley rats

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