Impact of overweight and underweight on IVF treatment in Chinese women

Abstract

At a lower cutoff point of BMI in Chinese women, overweight is associated with increased miscarriage risks and impaired response to ovarian stimulation after IVF and ICSI.

The effect of body mass index on the outcomes of first assisted reproductive technology cycles

“…Several studies have demonstrated decreased odds of CP in patients with higher BMI (9,10,16,31). However, many more studies have failed to identify a statistically significant difference (7,8,20,(25)(26)(27)(28)(29)(30), including two meta-analyses of 21 and 13 studies that demonstrated a lower chance of CP with obesity (32,33).…”

“…The majority of those studies had much smaller sample sizes, ranging from 72 to 278, and used binomial BMI classifications (10,(25)(26)(27). Two other studies included only Asian patients and three BMI categories (28,29), and Dokras et al analyzed data only from patients <38 years old (30).…”

Effect of Body Mass Index on In Vitro Maturation Treatment Outcomes in Women without Polycystic Ovarian Syndrome

“…Therefore a negative effect of abnormal BMI on clinical outcome cannot be excluded. Despite the differences between IVM and IVF cycles, our results should also be considered in the context of previous studies investigating effect of BMI on IVF outcomes, as both treatments also share common steps to successful implantation and delivery [3][4][5][6][7]20,21].…”

“…However, studies investigating the effect of obesity on IVF outcome have yielded contradictory results [3,4,6,7]. Variations in the results can be attributed to different study populations, random effects due to small sample sizes in some studies, different cut-off values of Body Mass Index (BMI) used to categorize participants, varying definitions of relevant outcome measures including pregnancy and miscarriage, and the lack of adjustment for potential confounders such as female age, the presence of Polycystic Ovarian Syndrome (PCOS), number of prior failed cycles in some studies [8,9].…”

The impact of lifestyle behaviors on infertility treatment outcome

“…Women with a low BMI (under 20, 19, or 18.5, depending on the study) have lower clinical pregnancy rates than normal weight women [17]. Underweight women also have an increased risk of miscarriage: a retrospective analysis of 594 patients showed pregnancy loss was 11% for underweight women compared to 0.5% for those with normal BMI [6 & ].…”