Impact of orthognathic surgery on quality of life of patients with dentofacial deformity: a systematic review and meta-analysis

Oral Health-Related Quality of Life Changes in Patients with Dentofacial Deformities Class II and III after Orthognathic Surgery: A Systematic Review and Meta-Analysis

“…We also found improvement in the OQLQ global score, but we could not construct a meta-analysis by OQLQ domain since only one study [ 24 ] stratified according to type of dentofacial deformity reported data by domains. Statistically significative improvement for all domains of the OQLQ and OHIP-14 was estimated by two other systematic reviews with meta-analyses [ 21 , 22 ], which was consistent with our results in Class III patients. However, we found no statistically significant improvement in physical pain or physical disability of OHIP-14 in Class II patients.…”

“…Previous systematic reviews consistently showed a positive impact of orthognathic surgery on OHRQoL in general [ 17 , 18 , 19 , 20 , 21 , 22 ], but none of them considered the type of dentofacial deformity. A meta-analysis of results focused on the OQLQ, specifically designed to measure the impact of the orthognathic surgery [ 20 ], showed improvement in the overall score and in the domains of social aspects and facial aesthetics.…”

“…The first systematic review [ 17 ] about quality of life assessment in patients with dentofacial deformities undergoing orthognathic surgery, published in 2013, described the different motivations and perceptions of patients towards surgical treatment, the methods and instruments used to measure quality of life and psychosocial aspects, but not the changes between before and after surgery. Subsequently, five systematic reviews, two with narrative synthesis [ 18 , 19 ], and the other three with quantitative synthesis through meta-analysis [ 20 , 21 , 22 ], have focused on this outcome, showing OHRQoL improvement. None of these systematic reviews stratified by type of dentofacial deformity, despite consistently reported differences between Class II and Class III patients [ 15 , 23 , 24 , 25 ].…”

Association of the estrogen receptor gene with oral health-related quality of life in patients with dentofacial deformities

“…Skeletal discrepancies in the facial bones of patients with DFD affect not only the individual's facial aesthetics, resulting in low self-esteem, 21 but also physiological problems that affect the oral health and overall perception of OHRQoL. 2,6 Orthognathic surgery usually has a positive impact on OHRQoL by improving the individual's facial aesthetics. 6 For this reason, many patients seek orthognathic surgery to improve their facial aesthetics and restore oral functions.…”

“…4 Many studies have evaluated OHRQoL in patients with DFD and found that these patients' oral health condition negatively impacts various psychosocial aspects of their lives. [4][5][6][7] Some factors, including age, 4,8 sex, 5 facial profile type, 9 and genetic factors, directly correlate with worsening OHRQoL. 10 Spranger et al 11 studied different candidate genes that were expected to play a role in the perception of QoL, including the estrogen receptor 1 (ESR1), which is associated with depression.…”