Impact of oral mucositis on oral‐health‐related quality of life of patients diagnosed with cancer

Barkokebas, Andreza; Silva, Igor Henrique Morais; Andrade, Samantha Cardoso De; Carvalho, Alessandra Albuquerque Tavares; Gueiros, Luiz Alcino Monteiro; Paiva, Saul Martins

doi:10.1111/jop.12282

Cited by 53 publications

(56 citation statements)

References 38 publications

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“…It occurs in about 30%–70% of patients treated with RT of the head and neck area and in 40%–80% of patients undergoing CT. When the two modalities are combined, the incidence of these lesions tends to increase, ranging from 50% to 100% …”

Section: Resultsmentioning

confidence: 99%

“…This takes into consideration clinical criteria, such as the presence and absence of injury, and subjective criteria, such as the presence of pain and ability to eat (Table ). Its clinical features vary according to the type of cancer therapy used and the health of the patient …”

Section: Resultsmentioning

confidence: 99%

“…It is characterized by the presence of ulcerated lesions in the oral cavity, which usually leads to difficulty in eating and consequential loss of weight and malnutrition, and susceptibility to opportunistic infections. OM affects the quality of life of patients and can become a dose‐limiting factor in treatment …”

Section: What Is Known and Objectivementioning

confidence: 99%

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Cannabidiol: an alternative therapeutic agent for oral mucositis?

et al. 2017

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SUMMARYWhat is known and objective: Chemo-and radiotherapy are therapeutic modalities often used in patients with malignant neoplasms. They kill tumour cells but act on healthy tissues as well, resulting in adverse effects. Oral mucositis is especially of concern, due to the morbidity that it causes. We reviewed the literature on the etiopathogenesis of oral mucositis and the activity of cannabidiol, to consider the possibility of its use for the prevention and treatment of oral mucositis. Methods: We searched the PubMed database and selected complete articles published in English that met the inclusion criteria for the period 1998-2016. The search terms 'cannabinoids', 'cannabidiol', 'oxidative stress', 'antioxidants' and 'oral mucositis' were used. Results and discussion: The control of oxidative stress may prevent and alleviate oral mucositis. Studies have demonstrated that cannabidiol is safe to use and possesses antioxidant, antiinflammatory and analgesic properties. What is new and conclusions: The literature on the use of cannabidiol in dentistry is still scarce. Studies investigating the use of cannabidiol in oral mucositis and other oxidative stressmediated side effects of chemotherapy and radiotherapy on the oral mucosa should be encouraged. WHAT IS KNOWN AND OBJECTIVEWith an increase in life expectancy and an ageing population, the frequency of chronic non-communicable diseases such as cancer has been increasing. Consequently, there is a greater demand for antineoplastic treatments, which are responsible for major adverse effects. Oral mucositis (OM) is a complication commonly observed, particularly with radiotherapy (RT) of the head and neck area and with chemotherapy (CT). It is a painful and debilitating condition of varying severity. It is characterized by the presence of ulcerated lesions in the oral cavity, which usually leads to difficulty in eating and consequential loss of weight and malnutrition, and susceptibility to opportunistic infections. OM affects the quality of life of patients and can become a dose-limiting factor in treatment. [1][2][3][4][5][6] There is considerable evidence that the cytotoxic effects of CT and RT result from physico-chemical reactions that lead to excessive production of free radicals (FR), which favours an oxidant-antioxidant imbalance and oxidative stress (OS). This could mediate the development of oral lesions and OM. 4,5,[7][8][9][10][11] However, despite our understanding of the pathogenesis of this condition, its prevention and treatment are still considered a challenge to the dentist.The use of cannabinoids, components of Cannabis sativa, in the treatment of complex diseases has been extensively investigated in different medical areas. Among the cannabinoids, cannabidiol (CBD) is the non-psychotropic cannabinoid of greatest abundance in the plant.12 According to reported studies, CBD has antioxidant, anti-inflammatory and immunomodulatory properties and is devoid of psychoactive properties, and its minimal side effects make it safe for use in humans. [12][...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Cannabidiol: an alternative therapeutic agent for oral mucositis?

et al. 2017

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“…Orofacial pain of neuropathic origin can arise as a consequence of surgery (tumor resection), chemotherapy, and radiotherapy, or combination therapy (1,58). Most of the patients undergoing chemotherapy and radiotherapy for head and neck cancers develop oral mucositis which is extremely painful (59,60). The quality of life for these patients gets severely diminished since for some of them it is too painful to eat, so an adequate nutrition is compromised.…”

Section: The Paradox Of Cancer Treatmentmentioning

confidence: 99%

Cancer and orofacial pain

Salvemini

2016

Med Oral

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BackgroundCancer pain is a devastating condition. Pain in the orofacial region, may be present as the single symptom of cancer or as a symptom of cancer in its later stages. This manuscript revises in a comprehensive manner the content of the conference entitled “Orofacial Pain and Cancer” (Dolor Orofacial y Cancer) given at the VI Simposio International “Advances in Oral Cancer” on the 22 July, 2016 in Donostia.Material and MethodsWe have reviewed (pubmed-medline) from the most relevant literature including reviews, systematic reviews and clinical cases, the significant and evidence-based mechanisms and mediators of cancer-associated facial pain, the diverse types of cancers that can be present in the craniofacial region locally or from distant sites that can refer to the orofacial region, cancer therapy that may induce pain in the orofacial region as well as discussed some of the new advancements in cancer pain therapy.ResultsThere is still a lack of understanding of cancer pain pathophysiology since depends of the intrinsic heterogeneity, type and anatomic location that the cancer may present, making more challenging the creation of better therapeutic options. Orofacial pain can arise from regional or distant tumor effects or as a consequence of cancer therapy.ConclusionsThe clinician needs to be aware that the pain may present the characteristics of any other orofacial pain disorder so a careful differential diagnosis needs to be given. Cancer pain diagnosis is made by exclusion and only can be reached after a thorough medical history, and all the common etiologies have been carefully investigated and ruled out. The current management tools are not optimal but there is hope for new, safer and effective therapies coming in the next years. Key words:Pain, orofacial, facial, cancer.

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“…These treatments have shown alterations of oral and perioral tissue, triggering signaling pathways that lead to histological changes in the epithelium lining of the digestive tract . This condition, termed oral mucositis, is associated with dysphagia, exhibiting a great impact in quality of life . There is some evidence related to the contribution of oral mucositis symptoms like xerostomia and dysphagia in appetite, taste perception, oral intake frequency, and weight loss in cancer patients .…”

Section: Introductionmentioning

confidence: 99%

Time‐Dependent Rheological Behavior of Starch‐Based Thickeners and Herb Infusion Dispersions for Dysphagia Management

et al. 2018

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The causes of dysphagia include neurological conditions and cancer. Swallowing impairment of liquids represents a risk of aspiration, pneumonia, dehydration, and nutritional deficiencies. Commercial thickeners often based on modified cornstarch address this issue. The herb Matico (Buddleja globosa Hope) is used as a wound‐healing adjuvant treatment for oral mucositis caused by cancer therapies. This study analyzes the flow behavior of Matico infusion with two thickeners, Thick & EasyTM, and Enterex® Food Thickener at three concentrations. A rheological assessment is performed (20 ± 1 °C subsequent intervals: 1–100 s−1, constant shear step at 100 s−1, and 100–1 s−1, each one with a 120 s span) at five time points (0–60 min). Rheological behavior is adjusted to the Herschel–Bulkley model. Significant differences (p < 0.05) are obtained for yield stress (σ0), consistency coefficient (K), and flow behavior index (n) between time‐points, supporting the increase in apparent viscosity (ηa) during rest. Shear thinning, Bingham plastic, and shear thickening behaviors are obtained for the three concentrations 4.5, 6.75, and 9.0 g 100 mL−1. Besides, a non‐reported rheopectic effect is found at the highest concentration, showing a consistent increase in ηa. These findings reveal the critical effect of time on thickener dispersions that might reduce safety and efficiency during the eating process.

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Impact of oral mucositis on oral‐health‐related quality of life of patients diagnosed with cancer

Abstract: Oral-health-related quality of life is significantly affected by OM in individuals diagnosed with cancer.

Cited by 53 publications

References 38 publications

Cannabidiol: an alternative therapeutic agent for oral mucositis?

Cannabidiol: an alternative therapeutic agent for oral mucositis?

Cancer and orofacial pain

Time‐Dependent Rheological Behavior of Starch‐Based Thickeners and Herb Infusion Dispersions for Dysphagia Management

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