Impact of oral immunotherapy on quality of life in egg‐allergic children

Vazquez‐Ortiz, Marta; Alvaro, Montserrat; Piquer, M.; Domínguez, Olga; Giner, M.T.; Lozano, J.J.; Jiménez‐Feijoo, Rosa; Plaza, Ana María

doi:10.1111/pai.12355

Cited by 24 publications

(28 citation statements)

References 10 publications

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“…However, a successful OIT is not always strictly related to a positive impact on children's quality of life (QoL). A recent study reported that parents perceived limited benefit from the child undergoing egg OIT; interestingly, the improvement in health‐related QoL was inversely associated with the frequency of OIT‐related reactions, suggesting that if safety is compromised, QoL does not improve . Similarly, health‐related QoL changes were not statistically different after a double‐blind placebo‐controlled OFC with cashew nut among children participating in a clinical trial .…”

Section: Therapeutic Approachesmentioning

confidence: 96%

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Mastrorilli

Caffarelli

Hoffmann‐Sommergruber

2017

Pediatric Allergy Immunology

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The rising burden of allergic diseases in childhood requires a compelling need to identify individuals at risk for atopy very early in life or even predict the onset of food allergy and atopic dermatitis since pregnancy. The development and clinical phenotypes of atopic diseases in childhood depend on a complex interaction between genetic and environmental factors, such as allergen exposure, air pollution, and infections. Preventive strategies may include avoidance measures, diet supplements, and early complementary food introduction. Overall, the management of allergic diseases has been improving to date toward a patient's tailored approach. This review will cover the current understanding of risk factors, prediction, and management of food allergy and atopic dermatitis in childhood and discuss how these may contribute to the modification of the natural history of food allergy and atopic dermatitis.

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Section: Therapeutic Approachesmentioning

confidence: 96%

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Mastrorilli

Caffarelli

Hoffmann‐Sommergruber

2017

Pediatric Allergy Immunology

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“…No studies have addressed the impact of OIT on HRQoL in the longer term, or in those patients who fail OIT due to reactions. A recent study reported that parents only perceived a very limited benefit from the child undergoing egg OIT; interestingly, the improvement in HRQoL correlated inversely with the frequency of OIT‐related reactions, suggesting that if safety is compromised, quality of life does not improve .…”

Section: Oral Immunotherapy For Food Allergymentioning

confidence: 99%

Improving the safety of oral immunotherapy for food allergy

Vazquez‐Ortiz

Turner

2015

Pediatric Allergy Immunology

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Food allergy is a major public health problem in children, impacting upon the affected individual, their families and others charged with their care, for example educational establishments, and the food industry. In contrast to most other paediatric diseases, there is no established cure: current management is based upon dietary avoidance and the provision of rescue medication in the event of accidental reactions, which are common. This strategy has significant limitations and impacts adversely on health‐related quality of life. In the last decade, research into disease‐modifying treatments for food allergy has emerged, predominantly for peanut, egg and cow's milk. Most studies have used the oral route (oral immunotherapy, OIT), in which increasing amounts of allergen are given over weeks–months. OIT has proven effective to induce immune modulation and ‘desensitization’ – that is, an increase in the amount of food allergen that can be consumed, so long as regular (typically daily) doses are continued. However, its ability to induce permanent tolerance once ongoing exposure has stopped seems limited. Additionally, the short‐ and long‐term safety of OIT is often poorly reported, raising concerns about its implementation in routine practice. Most patients experience allergic reactions and, although generally mild, severe reactions have occurred. Long‐term adherence is unclear, which rises concerns given the low rates of long‐term tolerance induction. Current research focuses on improving current limitations, especially safety. Strategies include alternative routes (sublingual, epicutaneous), modified hypoallergenic products and adjuvants (anti‐IgE, pre‐/probiotics). Biomarkers of safe/successful OIT are also under investigation.

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“…One uncontrolled study of egg allergic children found no difference in parent-perceived health-related quality of life (HRQL) scores from pre-to post-OIT [86]. However, child-reported HRQL scores were significantly improved after OIT.…”

Section: Effects On Quality Of Lifementioning

confidence: 94%

“…A pilot study of cow's milk OIT in patients 3-12 years using the FAQLQ parent form revealed significant improvements in all domains including food anxiety, emotional impact, and social and dietary limitations, particularly in patients over 4 years of age [88]. In addition to lack of a control group, many studies excluded patients who discontinued OIT because of frequent adverse reactions, so their results could represent an overestimation of the benefit of OIT on quality of life [86]. Controlled studies are needed to determine the effect of OIT on quality of life.…”

Section: Effects On Quality Of Lifementioning

confidence: 95%

Food specific oral immunotherapy: a potential treatment for food allergy

Burbank¹,

Burks

2015

Expert Review of Gastroenterology & Hepatology

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Food allergy is a potentially life-threatening condition affecting up to 8% of children and up to 2% of adults in westernized countries. There are currently no approved treatments for food allergy apart from avoidance. The apparent increase in incidence of food allergies over the past few decades calls attention to the need for effective, disease-modifying therapies for food allergies. Oral immunotherapy (OIT) is a promising experimental treatment in which food allergic patients consume increasing quantities of food in attempt to increase their threshold for allergic reaction. Studies are ongoing to determine whether OIT is capable of safely inducing not only desensitization but also tolerance to the allergenic foods. This article focuses on recent relevant studies of OIT for the treatment of common food allergies.

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Impact of oral immunotherapy on quality of life in egg‐allergic children

Cited by 24 publications

References 10 publications

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Improving the safety of oral immunotherapy for food allergy

Food specific oral immunotherapy: a potential treatment for food allergy

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