Impact of Nutritional Profile on Gut Microbiota Diversity in Patients with Celiac Disease

Soheilian‐Khorzoghi, Mona; Rezasoltani, Sama; Moheb-Alian, Ali; Yadegar, Abbas; Rostami‐Nejad, Mohammad; Looha, Mehdi Azizmohammad; Verma, Anil K.; Haddadi, Azam; Dabiri, Hossein

doi:10.1007/s00284-022-02820-w

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…This discrepancy might be related to the lack of reduction in FODMAP fibres (fructan/GOS) in the present study, as compared with other LFD studies that report on a significant reduction in these FODMAP (20)(21)(22)(23)39,40,43) . Another explanation for the discrepancy might be a possible presence of initially low abundances of Bifidobacterium, which has been reported in other trials of GFD-treated CeD patients (46)(47)(48)(49)(50)(51) . A low-gluten diet (52) and a GFD (53) have been shown to reduce Bifidobacterium abundance in healthy adult.…”

Section: Discussionmentioning

confidence: 86%

Effects of a low FODMAP diet on gut microbiota in individuals with treated coeliac disease having persistent gastrointestinal symptoms – a randomised controlled trial

Herfindal,

van Megen,

Gilde

et al. 2023

Br J Nutr

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Individuals with celiac disease (CeD) often experience gastrointestinal symptoms despite adherence to a gluten-free diet (GFD). While we recently showed that a diet low in fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs) successfully provided symptom relief in GFD-treated CeD patients, there have been concerns that the low FODMAP diet (LFD) could adversely affect the gut microbiota. Our main objective was therefore to investigate whether the LFD affects the faecal microbiota and related variables of gut health. In a randomized controlled trial GFD-treated CeD adults, having persistent gastrointestinal symptoms, were randomized to either consume a combined LFD and GFD (n = 39) for four weeks or continue with GFD (controls, n = 36). Compared to the control group, the LFD group displayed greater changes in the overall faecal microbiota profile (16S rRNA gene sequencing) from baseline to follow-up (within-subject β-diversity, P < 0.001), characterized by lower and higher follow-up abundances (%) of genus Anaerostipes (Pgroup < 0.001) and class Erysipelotrichia (Pgroup = 0.02), respectively. Compared to the control group, the LFD led to lower follow-up concentrations of faecal propionic and valeric acid (GC-FID) in participants with high concentrations at baseline (Pinteraction ≤ 0.009). No differences were found in faecal bacterial α-diversity (Pgroup ≥ 0.20) or in faecal neutrophil gelatinase-associated lipocalin (ELISA), a biomarker of gut integrity and inflammation (Pgroup = 0.74), between the groups at follow-up. The modest effects of the LFD on the gut microbiota and related variables in the CeD patients of the present study are encouraging given the beneficial effects of the LFD strategy to treat functional GI symptoms. (Registered at clinicaltrials.gov as NCT03678935).

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Section: Discussionmentioning

confidence: 86%

Effects of a low FODMAP diet on gut microbiota in individuals with treated coeliac disease having persistent gastrointestinal symptoms – a randomised controlled trial

Herfindal,

van Megen,

Gilde

et al. 2023

Br J Nutr

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“…High bean intake was particularly linked to lower Lactobacillus abundance. These findings suggest that the consumption of meat and beans might diminish essential gut bacteria, potentially influencing dietary effects and the continuation of CD symptoms through changes in gut microbiota abundance [ 28 ]. As a result, this dietary profile could also be harmful and cause the aforementioned insulin resistance, hyperinsulinemia, and cardiovascular disease [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of dietary patterns in celiac disease patients using factor analysis method and their relationship with dietary intakes and body mass index

Morvaridi,

Sadeghi,

Alavinejad

et al. 2024

BMC Nutr

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Background/Objectives Celiac disease (CD) is a systemic and autoimmune enteropathy of the gastrointestinal tract with malabsorption characteristics. The only effective treatment for CD is adhere strictly to a gluten-free diet (GFD) throughout life. We evaluated the dietary patterns in celiac disease patients and their association with dietary intakes and anthropometric measurements in Iran. Subjects/Methods This is a case-control study on 182 participants who were referred to the Khuzestan Celiac Association, Iran. Nutritional information was collected using a validated 147-item semi-quantitative food frequency questionnaire (FFQ). The software Stata (StataCorp, Version 14.0) was used to analyze the data. Principal component analysis (PCA) was used to obtain participants’ dietary patterns. Results A significant relationship was observed between age and body mass index (BMI) across quartiles of the healthy dietary pattern score (P < 0.001, P = 0.001, and P = 0.001, respectively), indicating that as age and BMI increased, participants demonstrated greater adherence to the healthy dietary pattern. Individuals with the highest adherence to the healthy dietary pattern had the lowest odds ratio for celiac disease (CD) (Q1: reference; Q2: 1.96, 95% CI: 0.84–4.55; Q3: 0.61, 95% CI: 0.27–1.42; Q4: 0.10, 95% CI: 0.03–0.33, P trend < 0.001), and this association remained significant after adjusting for BMI (adjusted P trend = 0.003) and energy intake (adjusted P trend < 0.001). Moreover, there was a significant association between the lowest odds ratio for CD and the highest adherence to the unhealthy dietary pattern after adjustment for energy intake (Q1: reference; Q2: 0.38, 95% CI: 0.13–1.12; Q3: 0.21, 95% CI: 0.06–0.71; Q4: 0.07, 95% CI: 0.02–0.29, adjusted P trend < 0.001). Additionally, a significant association was observed between the odds ratio for CD and the mixed dietary pattern score (Q1: reference; Q2: 6.01, 95% CI: 2.29–15.72; Q3: 2.47, 95% CI: 0.93–6.55; Q4: 4.84, 95% CI: 1.84–12.66, P trend = 0.02), and this association remained significant after adjustment for energy intake (adjusted P trend < 0.001). Conclusions The findings of the present study indicate that individuals who adhere to healthy dietary patterns have a lower incidence of celiac disease.

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“…Furthermore, it was demonstrated that microbial richness was reduced in treated CD patients with persistent symptoms following a higher relative abundance of Proteobacteria and a lower abundance of Bacteroidetes and Firmicutes while adhering to a strict GFD [ 18 ]. Our previous study also showed that meat and bean consumptions had an inverse effect on the abundance of beneficial bacteria like Firmicutes and Lactobacillus in CD patients, which means that paying attention to the food intake of CD patients is of great importance [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of probiotics on gut microbiota composition and clinical symptoms of coeliac disease patients following gluten-free diet

Soheilian Khorzoghi,

Rostami-Nejad,

Yadegar

et al. 2023

Contemporary Clinical Trials Communications

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Impact of Nutritional Profile on Gut Microbiota Diversity in Patients with Celiac Disease

Cited by 10 publications

References 33 publications

Effects of a low FODMAP diet on gut microbiota in individuals with treated coeliac disease having persistent gastrointestinal symptoms – a randomised controlled trial

Effects of a low FODMAP diet on gut microbiota in individuals with treated coeliac disease having persistent gastrointestinal symptoms – a randomised controlled trial

Assessment of dietary patterns in celiac disease patients using factor analysis method and their relationship with dietary intakes and body mass index

Impact of probiotics on gut microbiota composition and clinical symptoms of coeliac disease patients following gluten-free diet

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