Impact of Nigella sativa and Clove Oils on Cell Wall Genes Expression in Multidrug Resistant Staphylococcus aureus

Attia, Adel; El-Hamid, Marwa I. Abd; El-Reheem, Mohamed E. Abd; Fattah, Nehad A. Abd El

doi:10.21608/zvjz.2016.7859

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Methicillin-resistant S. aureus (MRSA) is a dangerous bacterial pathogen isolated from both community and clinical environments [8,9]. In recent years, chronic MRSA wound infections have become a big healthcare-associated problem that has detrimental effects on human quality of life [10][11][12][13]. According to the Centers for Disease Control and Prevention (CDC) report in 2018, the annual deaths caused by MRSA in the United States were estimated at 20,000 and this rate was higher than any other drugresistant pathogen [14].…”

Section: Introductionmentioning

confidence: 99%

Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance

Hemmati,

Chegini,

Arabestani

2023

Journal of Nanomaterials

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Staphylococcus aureus, a prominent bacterial pathogen, presents formidable medical challenges owing to its rapid development of resistance. The emergence of multidrug resistant (MDR) S. aureus strains has become a pressing concern for healthcare systems, driving researchers to explore novel therapeutic strategies for managing infections associated with this pathogen. In this pursuit, niosomal-based platforms have emerged as promising candidates to effectively target S. aureus and fight conventional antimicrobial resistance. Niosomes comprise a bilayer membrane formed by nonionic surfactants, which can encapsulate both hydrophilic and hydrophobic drugs. These nanoparticles are known as vesicular delivery systems and have many advantages, such as low cost, less toxicity, and more flexibility and stability. Moreover, niosomes, being an effective drug delivery system, can directly interact with the bacterial cell envelope, thereby enhancing the pharmacokinetic activities of drugs at infected sites. A niosome-based delivery system can effectively treat S. aureus infections by destroying the biofilm community, increasing intracellular targeting, and enhancing the antibacterial activity. The main mechanisms of action of niosomes against resistant S. aureus strains involve the ability to resist enzymatic degradation, controlled release profile, and targeted drug delivery, which can provide an effective dosage of antimicrobial agents at the site of actions. In addition, niosomes have the potential to transfer wide-spectrum materials from different classes of antibiotics to nonantibiotic antimicrobial agents, such as natural compounds, antimicrobial peptides, and metallic nanoparticles. The combination of polymeric materials in the structure of a niosomal formulation could improve their bioavailability, loading capacity, and therapeutic efficacy for different applications. Furthermore, niosomes could find application in photodynamic therapy, offering a promising alternative to conventional treatments for eradicating drug-resistant S. aureus isolates. Finally, niosomal nanocarriers can be developed for delivering the drugs to desired sites by different routes of administration and could be considered a powerful strategy for overcoming the therapeutic obstacles caused by MDR S. aureus.

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Section: Introductionmentioning

confidence: 99%

Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance

Hemmati,

Chegini,

Arabestani

2023

Journal of Nanomaterials

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The impact of essential oils on antibiotic use in animal production regarding antimicrobial resistance – a review

Evangelista

Corrêa

Pinto

et al. 2021

Critical Reviews in Food Science and Nutrition

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EXISTENCE OF VANCOMYCIN RESISTANCE AMONG METHICILLIN RESISTANT S. aureus RECOVERED FROM ANIMAL AND HUMAN SOURCES IN EGYPT

El-Aziz¹,

El-Hamid²,

Bendary³

et al. 2018

SVR

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The increased resistance of vancomycin among methicillin resistant Staphylococcus aureus (MRSA) has produced a major formidable threat in the therapeutic field. The current study analyzed the vancomycin resistance traits among MRSA isolates recovered from 148 samples of animal and human origins in Sharkia Governorate, Egypt. All staphylococci isolates were examined against 8 antimicrobials and vancomycin minimal inhibitory concentrations (MICs) were then determined among phenotypic vancomycin resistant and intermediate S. aureus. Furthermore, all vancomycin-resistant S. aureus (VRSA) isolates were exposed to PCR analysis of mecA and van genes. Herein, 45 of 86 Staphylococcus spp. were identified as S. aureus, while 41 were coagulase negative staphylococci (CoNS). A higher incidence rate of S. aureus was observed in meat products (58.06%), but majority of CoNS isolates were isolated from milk samples (54.54%) with no statistical differences (P < 0.05) in the distribution of S. aureus and CoNS among all samples. Oxacillin and amoxicillin-clavulanic acid recorded the highest resistance percentages among S. aureus (93.33 and 88.89%) and CoNS (75.61 and 87.80%), respectively. Multidrug resistance (MDR) was detected in high proportions of S. aureus (64.4%) and CoNS (34.1%). Forty-two of 45 S. aureus isolates were MRSA, of which 14 were vancomycin resistant with MIC values ranged from 32-1024 μg/mL. PCR detection of mecA and van genes in the tested isolates revealed that they were all mecA gene positive, while 10 out of them had van genes. The vanB gene was found in 5 isolates with higher MICs (64- 256 μg/mL), while vanA gene was detected in 4 isolates with MICs of 128-512 μg/mL and only one isolate harbored both vanA and vanB genes with MIC value of 1024 μg/mL. According to the upsurge of VRSA prevalence rates, more attentions should be oriented for continuous monitoring of antimicrobial usage with the need for effective drugs against VRSA.

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Impact of Nigella sativa and Clove Oils on Cell Wall Genes Expression in Multidrug Resistant Staphylococcus aureus

Cited by 3 publications

References 16 publications

Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance

Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance

The impact of essential oils on antibiotic use in animal production regarding antimicrobial resistance – a review

EXISTENCE OF VANCOMYCIN RESISTANCE AMONG METHICILLIN RESISTANT S. aureus RECOVERED FROM ANIMAL AND HUMAN SOURCES IN EGYPT

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